Zinc in PDB 4tvr: Tandem Tudor and Phd Domains of UHRF2

The structure of Tandem Tudor and Phd Domains of UHRF2, PDB code: 4tvr was solved by J.R.Walker, A.Dong, Q.Zhang, M.Ong, S.Duan, Y.Li, C.Bountra, J.Weigelt, A.M.Edwards, C.H.Arrowsmith, Y.Tong, Structural Genomics Consortium(Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 2.29
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	71.280, 71.280, 120.052, 90.00, 90.00, 90.00
R / Rfree (%)	22.9 / 26

The binding sites of Zinc atom in the Tandem Tudor and Phd Domains of UHRF2 (pdb code 4tvr). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Tandem Tudor and Phd Domains of UHRF2, PDB code: 4tvr:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the Tandem Tudor and Phd Domains of UHRF2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Tandem Tudor and Phd Domains of UHRF2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:87.0 occ:1.00 SG A:CYS331 2.3 0.6 1.0 SG A:CYS342 2.3 0.5 1.0 SG A:CYS334 2.3 0.0 1.0 SG A:CYS345 2.3 0.1 1.0 CB A:CYS331 3.4 1.0 1.0 CB A:CYS345 3.4 0.9 1.0 CB A:CYS334 3.4 0.2 1.0 CB A:CYS342 3.5 0.5 1.0 N A:CYS334 3.7 0.5 1.0 N A:CYS345 4.1 0.7 1.0 CA A:CYS334 4.1 1.0 1.0 CA A:CYS345 4.4 0.8 1.0 CB A:LEU333 4.4 0.2 1.0 CB A:SER344 4.7 0.6 1.0 N A:GLY335 4.8 0.5 1.0 C A:LEU333 4.8 0.5 1.0 CA A:CYS331 4.8 0.8 1.0 C A:CYS334 4.8 0.1 1.0 CA A:CYS342 4.9 0.8 1.0 NZ A:LYS353 5.0 0.8 1.0 N A:GLY336 5.0 0.7 1.0 CA A:LEU333 5.0 0.1 1.0

Zinc binding site 2 out of 3 in the Tandem Tudor and Phd Domains of UHRF2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Tandem Tudor and Phd Domains of UHRF2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn402 b:94.9 occ:1.00 ND1 A:HIS370 2.1 0.9 1.0 SG A:CYS373 2.3 0.4 1.0 SG A:CYS350 2.3 0.4 1.0 SG A:CYS347 2.3 0.5 1.0 CE1 A:HIS370 2.9 0.0 1.0 CG A:HIS370 3.2 0.3 1.0 CB A:CYS347 3.4 0.6 1.0 CB A:CYS373 3.4 0.8 1.0 CB A:CYS350 3.4 0.6 1.0 CB A:HIS370 3.6 0.0 1.0 N A:CYS350 3.9 0.7 1.0 NE2 A:HIS370 4.1 0.5 1.0 CD2 A:HIS370 4.2 0.3 1.0 CA A:CYS350 4.2 0.1 1.0 N A:HIS370 4.3 0.4 1.0 CA A:HIS370 4.6 0.9 1.0 CB A:VAL349 4.7 0.6 1.0 CA A:CYS373 4.8 0.3 1.0 CA A:CYS347 4.8 0.7 1.0 N A:GLY351 4.9 0.1 1.0 C A:VAL349 4.9 0.9 1.0 CE1 A:TYR372 5.0 0.3 1.0 C A:CYS350 5.0 0.7 1.0

Zinc binding site 3 out of 3 in the Tandem Tudor and Phd Domains of UHRF2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Tandem Tudor and Phd Domains of UHRF2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn403 b:0.9 occ:1.00 SG A:CYS389 2.3 0.5 1.0 SG A:CYS362 2.3 0.2 1.0 SG A:CYS365 2.3 0.3 1.0 CB A:CYS362 3.4 0.1 1.0 CB A:CYS389 3.4 0.4 1.0 CB A:CYS365 3.4 0.6 1.0 N A:CYS365 3.8 0.4 1.0 CA A:CYS365 4.2 0.2 1.0 N A:CYS389 4.3 0.9 1.0 CA A:CYS389 4.5 0.1 1.0 N A:ASN366 4.5 0.4 1.0 C A:CYS365 4.8 0.3 1.0 CB A:GLU364 4.8 0.9 1.0 CB A:CYS392 4.8 0.5 1.0 CA A:CYS362 4.8 0.9 1.0 CG2 A:VAL367 4.9 0.7 1.0 C A:GLU364 5.0 0.3 1.0

J.R.Walker, A.Dong, Q.Zhang, M.Ong, S.Duan, Y.Li, C.Bountra, J.Weigelt, A.M.Edwards, C.H.Arrowsmith, Y.Tong, Structural Genomics Consortium (Sgc). Structure of the Tandem Tudor and Phd Domains of UHRF2 To Be Published.