Zinc in PDB 4qo1: P53 Dna Binding Domain in Complex with NB139

The structure of P53 Dna Binding Domain in Complex with NB139, PDB code: 4qo1 was solved by S.De Gieter, J.Bethuyne, J.Gettemans, A.Garcia-Pino, R.Loris, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.82 / 1.92
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	46.360, 68.280, 109.960, 90.00, 90.00, 90.00
R / Rfree (%)	16.5 / 20.5

The binding sites of Zinc atom in the P53 Dna Binding Domain in Complex with NB139 (pdb code 4qo1). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the P53 Dna Binding Domain in Complex with NB139, PDB code: 4qo1:

Zinc binding site 1 out of 1 in the P53 Dna Binding Domain in Complex with NB139


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of P53 Dna Binding Domain in Complex with NB139 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn401 b:20.5 occ:1.00 ND1 B:HIS179 2.0 24.0 1.0 SG B:CYS242 2.2 20.0 1.0 SG B:CYS238 2.4 24.1 1.0 SG B:CYS176 2.4 20.2 1.0 CE1 B:HIS179 3.0 27.7 1.0 CG B:HIS179 3.0 26.7 1.0 CB B:CYS242 3.1 21.7 1.0 CB B:HIS179 3.4 21.5 1.0 CB B:CYS238 3.4 22.9 1.0 CB B:CYS176 3.5 18.4 1.0 CA B:CYS238 3.9 17.2 1.0 N B:CYS176 4.0 20.7 1.0 NE2 B:HIS179 4.1 26.5 1.0 CD2 B:HIS179 4.1 22.5 1.0 CA B:CYS176 4.3 20.4 1.0 N B:HIS179 4.4 23.8 1.0 N B:ASN239 4.4 16.7 1.0 CA B:CYS242 4.5 22.3 1.0 CA B:HIS179 4.5 23.9 1.0 C B:CYS238 4.7 19.9 1.0 O B:MET237 4.7 18.6 1.0 O B:HOH723 4.8 31.8 1.0 O B:CYS176 4.9 19.0 1.0 C B:CYS176 4.9 19.1 1.0

J.Bethuyne, S.De Gieter, O.Zwaenepoel, A.Garcia-Pino, K.Durinck, A.Verhelle, G.Hassanzadeh-Ghassabeh, F.Speleman, R.Loris, J.Gettemans. A Nanobody Modulates the P53 Transcriptional Program Without Perturbing Its Functional Architecture. Nucleic Acids Res. 2014.
ISSN: ESSN 1362-4962
PubMed: 25324313
DOI: 10.1093/NAR/GKU962