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Zinc in PDB 4qk2: Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II - E234P

Enzymatic activity of Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II - E234P

All present enzymatic activity of Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II - E234P:
4.2.1.1;

Protein crystallography data

The structure of Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II - E234P, PDB code: 4qk2 was solved by C.D.Boone, V.Rasi, R.Mckenna, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.92 / 1.52
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.235, 41.082, 71.912, 90.00, 104.30, 90.00
R / Rfree (%) 15.9 / 17.8

Zinc Binding Sites:

The binding sites of Zinc atom in the Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II - E234P (pdb code 4qk2). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II - E234P, PDB code: 4qk2:

Zinc binding site 1 out of 1 in 4qk2

Go back to Zinc Binding Sites List in 4qk2
Zinc binding site 1 out of 1 in the Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II - E234P


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II - E234P within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:14.2
occ:1.00
 O A:HOH408 1.9 13.6 1.0
NE2 A:HIS94 2.0 6.6 1.0
NE2 A:HIS96 2.0 6.3 1.0
ND1 A:HIS119 2.1 8.0 1.0
CE1 A:HIS119 2.9 8.5 1.0
CD2 A:HIS94 3.0 7.5 1.0
CE1 A:HIS96 3.0 9.0 1.0
HE1 A:HIS119 3.0 10.2 1.0
CD2 A:HIS96 3.0 8.2 1.0
CE1 A:HIS94 3.0 7.0 1.0
HD2 A:HIS94 3.1 9.0 1.0
CG A:HIS119 3.2 8.1 1.0
HE1 A:HIS96 3.2 10.8 1.0
HB2 A:HIS119 3.2 8.2 1.0
HD2 A:HIS96 3.2 9.8 1.0
HE1 A:HIS94 3.2 8.4 1.0
HG1 A:THR199 3.5 9.1 1.0
CB A:HIS119 3.6 6.8 1.0
O A:HOH406 3.6 17.0 1.0
HB3 A:HIS119 3.8 8.2 1.0
OG1 A:THR199 3.8 7.6 1.0
O A:HOH425 4.0 24.9 1.0
OE1 A:GLU106 4.0 8.2 1.0
NE2 A:HIS119 4.1 7.1 1.0
ND1 A:HIS94 4.1 6.9 1.0
CG A:HIS94 4.1 8.4 1.0
ND1 A:HIS96 4.1 7.4 1.0
CG A:HIS96 4.2 8.5 1.0
CD2 A:HIS119 4.2 7.7 1.0
HH2 A:TRP209 4.3 10.8 1.0
O A:HOH418 4.3 23.2 1.0
HG23 A:THR200 4.9 11.3 1.0
CD A:GLU106 4.9 8.9 1.0
O A:HOH439 5.0 30.0 1.0

Reference:

C.D.Boone, V.Rasi, C.Tu, R.Mckenna. Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II. Febs J. 2015.
ISSN: ISSN 1742-464X
PubMed: 25683338
DOI: 10.1111/FEBS.13232
Page generated: Wed Dec 16 05:43:51 2020

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