Zinc in PDB 4kx7: Crystal Structure of Human Aminopeptidase A

All present enzymatic activity of Crystal Structure of Human Aminopeptidase A:
3.4.11.7;

The structure of Crystal Structure of Human Aminopeptidase A, PDB code: 4kx7 was solved by Y.Yang, C.Liu, Y.Y.Lin, F.Li, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	38.86 / 2.15
Space group	P 64 2 2
Cell size a, b, c (Å), α, β, γ (°)	142.340, 142.340, 237.446, 90.00, 90.00, 120.00
R / Rfree (%)	17.3 / 21.8

The binding sites of Zinc atom in the Crystal Structure of Human Aminopeptidase A (pdb code 4kx7). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Human Aminopeptidase A, PDB code: 4kx7:

Zinc binding site 1 out of 1 in the Crystal Structure of Human Aminopeptidase A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human Aminopeptidase A within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:80.8 occ:1.00 OE1 A:GLU416 2.0 59.9 1.0 NE2 A:HIS397 2.2 54.4 1.0 NE2 A:HIS393 2.3 50.9 1.0 O A:HOH1656 2.8 67.2 1.0 CD A:GLU416 3.0 59.9 1.0 O A:HOH1670 3.0 69.9 1.0 CD2 A:HIS393 3.1 48.6 1.0 CD2 A:HIS397 3.1 53.0 1.0 CE1 A:HIS397 3.2 55.3 1.0 OE2 A:GLU416 3.2 64.9 1.0 CE1 A:HIS393 3.4 48.0 1.0 O A:HOH1546 3.6 57.6 1.0 OH A:TYR479 3.8 55.7 1.0 CE2 A:TYR479 3.9 42.6 1.0 CZ A:TYR479 4.2 49.2 1.0 CB A:ALA419 4.3 50.8 1.0 ND1 A:HIS397 4.3 53.5 1.0 CG A:HIS397 4.3 53.7 1.0 CG A:HIS393 4.4 44.9 1.0 OE1 A:GLU360 4.4 61.3 1.0 CG A:GLU416 4.4 59.6 1.0 ND1 A:HIS393 4.5 48.0 1.0 CA A:GLU416 4.6 53.1 1.0 OE2 A:GLU360 4.8 55.2 1.0 O A:HOH1269 4.8 57.8 1.0 OE2 A:GLU394 4.8 54.3 1.0 CB A:GLU416 4.8 56.0 1.0 CD A:GLU360 4.8 56.2 1.0 CD2 A:TYR479 4.9 41.7 1.0

Y.Yang, C.Liu, Y.L.Lin, F.Li. Structural Insights Into Central Hypertension Regulation By Human Aminopeptidase A. J.Biol.Chem. V. 288 25638 2013.
ISSN: ISSN 0021-9258
PubMed: 23888046
DOI: 10.1074/JBC.M113.494955