Atomistry » Zinc » PDB 4ggk-4gsz » 4gsf
Atomistry »
  Zinc »
    PDB 4ggk-4gsz »
      4gsf »

Zinc in PDB 4gsf: The Structure Analysis of Cysteine Free Insulin Degrading Enzyme (Ide) with (S)-2-{2-[Carboxymethyl-(3-Phenyl-Propionyl)-Amino]- Acetylamino}-3-(3H-Imidazol-4-Yl)-Propionic Acid Methyl Ester

Enzymatic activity of The Structure Analysis of Cysteine Free Insulin Degrading Enzyme (Ide) with (S)-2-{2-[Carboxymethyl-(3-Phenyl-Propionyl)-Amino]- Acetylamino}-3-(3H-Imidazol-4-Yl)-Propionic Acid Methyl Ester

All present enzymatic activity of The Structure Analysis of Cysteine Free Insulin Degrading Enzyme (Ide) with (S)-2-{2-[Carboxymethyl-(3-Phenyl-Propionyl)-Amino]- Acetylamino}-3-(3H-Imidazol-4-Yl)-Propionic Acid Methyl Ester:
3.4.24.56;

Protein crystallography data

The structure of The Structure Analysis of Cysteine Free Insulin Degrading Enzyme (Ide) with (S)-2-{2-[Carboxymethyl-(3-Phenyl-Propionyl)-Amino]- Acetylamino}-3-(3H-Imidazol-4-Yl)-Propionic Acid Methyl Ester, PDB code: 4gsf was solved by Q.Guo, R.Deprez-Poulain, B.Deprez, W.J.Tang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.70
Space group P 65
Cell size a, b, c (Å), α, β, γ (°) 263.179, 263.179, 90.557, 90.00, 90.00, 120.00
R / Rfree (%) 17.4 / 22

Zinc Binding Sites:

The binding sites of Zinc atom in the The Structure Analysis of Cysteine Free Insulin Degrading Enzyme (Ide) with (S)-2-{2-[Carboxymethyl-(3-Phenyl-Propionyl)-Amino]- Acetylamino}-3-(3H-Imidazol-4-Yl)-Propionic Acid Methyl Ester (pdb code 4gsf). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the The Structure Analysis of Cysteine Free Insulin Degrading Enzyme (Ide) with (S)-2-{2-[Carboxymethyl-(3-Phenyl-Propionyl)-Amino]- Acetylamino}-3-(3H-Imidazol-4-Yl)-Propionic Acid Methyl Ester, PDB code: 4gsf:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 4gsf

Go back to Zinc Binding Sites List in 4gsf
Zinc binding site 1 out of 2 in the The Structure Analysis of Cysteine Free Insulin Degrading Enzyme (Ide) with (S)-2-{2-[Carboxymethyl-(3-Phenyl-Propionyl)-Amino]- Acetylamino}-3-(3H-Imidazol-4-Yl)-Propionic Acid Methyl Ester


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of The Structure Analysis of Cysteine Free Insulin Degrading Enzyme (Ide) with (S)-2-{2-[Carboxymethyl-(3-Phenyl-Propionyl)-Amino]- Acetylamino}-3-(3H-Imidazol-4-Yl)-Propionic Acid Methyl Ester within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1102

b:44.8
occ:1.00
 OE1 A:GLU189 1.9 29.9 1.0
NE2 A:HIS108 2.1 29.6 1.0
NE2 A:HIS112 2.2 26.4 1.0
CD A:GLU189 2.7 31.1 1.0
OE2 A:GLU189 2.8 31.2 1.0
CE1 A:HIS108 3.0 26.4 1.0
CE1 A:HIS112 3.1 26.2 1.0
CD2 A:HIS108 3.1 28.0 1.0
CD2 A:HIS112 3.2 26.7 1.0
ND1 A:HIS108 4.1 28.7 1.0
CG A:HIS108 4.2 27.3 1.0
CG A:GLU189 4.2 26.5 1.0
ND1 A:HIS112 4.2 28.9 1.0
CG A:HIS112 4.3 25.9 1.0
OE1 A:GLN111 4.4 29.9 1.0
OH A:TYR831 4.4 27.2 1.0
NE2 A:GLN111 4.6 25.4 1.0
CE1 A:TYR831 4.6 32.9 1.0
CD A:GLN111 4.8 26.9 1.0
CB A:GLU189 4.9 28.2 1.0

Zinc binding site 2 out of 2 in 4gsf

Go back to Zinc Binding Sites List in 4gsf
Zinc binding site 2 out of 2 in the The Structure Analysis of Cysteine Free Insulin Degrading Enzyme (Ide) with (S)-2-{2-[Carboxymethyl-(3-Phenyl-Propionyl)-Amino]- Acetylamino}-3-(3H-Imidazol-4-Yl)-Propionic Acid Methyl Ester


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of The Structure Analysis of Cysteine Free Insulin Degrading Enzyme (Ide) with (S)-2-{2-[Carboxymethyl-(3-Phenyl-Propionyl)-Amino]- Acetylamino}-3-(3H-Imidazol-4-Yl)-Propionic Acid Methyl Ester within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn1102

b:49.2
occ:1.00
 OE1 B:GLU189 2.0 35.5 1.0
NE2 B:HIS108 2.2 30.7 1.0
NE2 B:HIS112 2.2 33.3 1.0
CD B:GLU189 2.8 35.7 1.0
CE1 B:HIS108 3.0 31.0 1.0
OE2 B:GLU189 3.0 33.7 1.0
CE1 B:HIS112 3.1 36.1 1.0
CD2 B:HIS112 3.1 33.3 1.0
CD2 B:HIS108 3.3 31.4 1.0
NE2 B:GLN111 3.9 30.6 1.0
ND1 B:HIS108 4.2 31.8 1.0
ND1 B:HIS112 4.2 33.9 1.0
CG B:HIS112 4.3 32.6 1.0
CG B:GLU189 4.3 32.9 1.0
CG B:HIS108 4.3 29.4 1.0
CE1 B:TYR831 4.3 39.2 1.0
OH B:TYR831 4.3 41.4 1.0
OE1 B:GLN111 4.4 26.1 1.0
CD B:GLN111 4.6 28.0 1.0
CZ B:TYR831 4.8 39.6 1.0
CB B:GLU189 4.9 32.7 1.0

Reference:

Q.Guo, R.Deprez-Poulain, B.Deprez, W.J.Tang. The Structure Analysis of Cysteine Free Insulin Degrading Enzyme (Ide) with (S)-2-{2-[Carboxymethyl-(3-Phenyl-Propionyl)-Amino]- Acetylamino}-3-(3H-Imidazol-4-Yl)-Propionic Acid Methyl Ester To Be Published.
Page generated: Sat Oct 26 23:29:02 2024

Last articles

Zn in 9MJ5
Zn in 9HNW
Zn in 9G0L
Zn in 9FNE
Zn in 9DZN
Zn in 9E0I
Zn in 9D32
Zn in 9DAK
Zn in 8ZXC
Zn in 8ZUF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy