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Zinc in PDB 4gsf: The Structure Analysis of Cysteine Free Insulin Degrading Enzyme (Ide) with (S)-2-{2-[Carboxymethyl-(3-Phenyl-Propionyl)-Amino]- Acetylamino}-3-(3H-Imidazol-4-Yl)-Propionic Acid Methyl Ester

Enzymatic activity of The Structure Analysis of Cysteine Free Insulin Degrading Enzyme (Ide) with (S)-2-{2-[Carboxymethyl-(3-Phenyl-Propionyl)-Amino]- Acetylamino}-3-(3H-Imidazol-4-Yl)-Propionic Acid Methyl Ester

All present enzymatic activity of The Structure Analysis of Cysteine Free Insulin Degrading Enzyme (Ide) with (S)-2-{2-[Carboxymethyl-(3-Phenyl-Propionyl)-Amino]- Acetylamino}-3-(3H-Imidazol-4-Yl)-Propionic Acid Methyl Ester:
3.4.24.56;

Protein crystallography data

The structure of The Structure Analysis of Cysteine Free Insulin Degrading Enzyme (Ide) with (S)-2-{2-[Carboxymethyl-(3-Phenyl-Propionyl)-Amino]- Acetylamino}-3-(3H-Imidazol-4-Yl)-Propionic Acid Methyl Ester, PDB code: 4gsf was solved by Q.Guo, R.Deprez-Poulain, B.Deprez, W.J.Tang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.70
Space group P 65
Cell size a, b, c (Å), α, β, γ (°) 263.179, 263.179, 90.557, 90.00, 90.00, 120.00
R / Rfree (%) 17.4 / 22

Zinc Binding Sites:

The binding sites of Zinc atom in the The Structure Analysis of Cysteine Free Insulin Degrading Enzyme (Ide) with (S)-2-{2-[Carboxymethyl-(3-Phenyl-Propionyl)-Amino]- Acetylamino}-3-(3H-Imidazol-4-Yl)-Propionic Acid Methyl Ester (pdb code 4gsf). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the The Structure Analysis of Cysteine Free Insulin Degrading Enzyme (Ide) with (S)-2-{2-[Carboxymethyl-(3-Phenyl-Propionyl)-Amino]- Acetylamino}-3-(3H-Imidazol-4-Yl)-Propionic Acid Methyl Ester, PDB code: 4gsf:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 4gsf

Go back to Zinc Binding Sites List in 4gsf
Zinc binding site 1 out of 2 in the The Structure Analysis of Cysteine Free Insulin Degrading Enzyme (Ide) with (S)-2-{2-[Carboxymethyl-(3-Phenyl-Propionyl)-Amino]- Acetylamino}-3-(3H-Imidazol-4-Yl)-Propionic Acid Methyl Ester


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of The Structure Analysis of Cysteine Free Insulin Degrading Enzyme (Ide) with (S)-2-{2-[Carboxymethyl-(3-Phenyl-Propionyl)-Amino]- Acetylamino}-3-(3H-Imidazol-4-Yl)-Propionic Acid Methyl Ester within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1102

b:44.8
occ:1.00
 OE1 A:GLU189 1.9 29.9 1.0
NE2 A:HIS108 2.1 29.6 1.0
NE2 A:HIS112 2.2 26.4 1.0
CD A:GLU189 2.7 31.1 1.0
OE2 A:GLU189 2.8 31.2 1.0
CE1 A:HIS108 3.0 26.4 1.0
CE1 A:HIS112 3.1 26.2 1.0
CD2 A:HIS108 3.1 28.0 1.0
CD2 A:HIS112 3.2 26.7 1.0
ND1 A:HIS108 4.1 28.7 1.0
CG A:HIS108 4.2 27.3 1.0
CG A:GLU189 4.2 26.5 1.0
ND1 A:HIS112 4.2 28.9 1.0
CG A:HIS112 4.3 25.9 1.0
OE1 A:GLN111 4.4 29.9 1.0
OH A:TYR831 4.4 27.2 1.0
NE2 A:GLN111 4.6 25.4 1.0
CE1 A:TYR831 4.6 32.9 1.0
CD A:GLN111 4.8 26.9 1.0
CB A:GLU189 4.9 28.2 1.0

Zinc binding site 2 out of 2 in 4gsf

Go back to Zinc Binding Sites List in 4gsf
Zinc binding site 2 out of 2 in the The Structure Analysis of Cysteine Free Insulin Degrading Enzyme (Ide) with (S)-2-{2-[Carboxymethyl-(3-Phenyl-Propionyl)-Amino]- Acetylamino}-3-(3H-Imidazol-4-Yl)-Propionic Acid Methyl Ester


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of The Structure Analysis of Cysteine Free Insulin Degrading Enzyme (Ide) with (S)-2-{2-[Carboxymethyl-(3-Phenyl-Propionyl)-Amino]- Acetylamino}-3-(3H-Imidazol-4-Yl)-Propionic Acid Methyl Ester within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn1102

b:49.2
occ:1.00
 OE1 B:GLU189 2.0 35.5 1.0
NE2 B:HIS108 2.2 30.7 1.0
NE2 B:HIS112 2.2 33.3 1.0
CD B:GLU189 2.8 35.7 1.0
CE1 B:HIS108 3.0 31.0 1.0
OE2 B:GLU189 3.0 33.7 1.0
CE1 B:HIS112 3.1 36.1 1.0
CD2 B:HIS112 3.1 33.3 1.0
CD2 B:HIS108 3.3 31.4 1.0
NE2 B:GLN111 3.9 30.6 1.0
ND1 B:HIS108 4.2 31.8 1.0
ND1 B:HIS112 4.2 33.9 1.0
CG B:HIS112 4.3 32.6 1.0
CG B:GLU189 4.3 32.9 1.0
CG B:HIS108 4.3 29.4 1.0
CE1 B:TYR831 4.3 39.2 1.0
OH B:TYR831 4.3 41.4 1.0
OE1 B:GLN111 4.4 26.1 1.0
CD B:GLN111 4.6 28.0 1.0
CZ B:TYR831 4.8 39.6 1.0
CB B:GLU189 4.9 32.7 1.0

Reference:

Q.Guo, R.Deprez-Poulain, B.Deprez, W.J.Tang. The Structure Analysis of Cysteine Free Insulin Degrading Enzyme (Ide) with (S)-2-{2-[Carboxymethyl-(3-Phenyl-Propionyl)-Amino]- Acetylamino}-3-(3H-Imidazol-4-Yl)-Propionic Acid Methyl Ester To Be Published.
Page generated: Sat Oct 26 23:29:02 2024

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