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Zinc in PDB 4cum: Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (9AS)-2-Amino-9A-Methyl-6,7,8,9,9A, 10-Hexahydrobenzo[G]Pteridin-4(3H)-One

Enzymatic activity of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (9AS)-2-Amino-9A-Methyl-6,7,8,9,9A, 10-Hexahydrobenzo[G]Pteridin-4(3H)-One

All present enzymatic activity of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (9AS)-2-Amino-9A-Methyl-6,7,8,9,9A, 10-Hexahydrobenzo[G]Pteridin-4(3H)-One:
1.14.13.39;

Protein crystallography data

The structure of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (9AS)-2-Amino-9A-Methyl-6,7,8,9,9A, 10-Hexahydrobenzo[G]Pteridin-4(3H)-One, PDB code: 4cum was solved by G.Chreifi, H.Li, T.L.Poulos, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 88.04 / 2.33
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 58.011, 106.493, 156.480, 90.00, 90.00, 90.00
R / Rfree (%) 16.951 / 22.703

Other elements in 4cum:

The structure of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (9AS)-2-Amino-9A-Methyl-6,7,8,9,9A, 10-Hexahydrobenzo[G]Pteridin-4(3H)-One also contains other interesting chemical elements:

Arsenic (As) 2 atoms
Iron (Fe) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (9AS)-2-Amino-9A-Methyl-6,7,8,9,9A, 10-Hexahydrobenzo[G]Pteridin-4(3H)-One (pdb code 4cum). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (9AS)-2-Amino-9A-Methyl-6,7,8,9,9A, 10-Hexahydrobenzo[G]Pteridin-4(3H)-One, PDB code: 4cum:

Zinc binding site 1 out of 1 in 4cum

Go back to Zinc Binding Sites List in 4cum
Zinc binding site 1 out of 1 in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (9AS)-2-Amino-9A-Methyl-6,7,8,9,9A, 10-Hexahydrobenzo[G]Pteridin-4(3H)-One


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (9AS)-2-Amino-9A-Methyl-6,7,8,9,9A, 10-Hexahydrobenzo[G]Pteridin-4(3H)-One within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1483

b:49.4
occ:1.00
 SG B:CYS101 2.3 46.7 1.0
SG A:CYS96 2.3 49.0 1.0
SG A:CYS101 2.4 47.5 1.0
SG B:CYS96 2.4 47.8 1.0
CB B:CYS101 3.2 45.8 1.0
CB A:CYS101 3.3 47.7 1.0
CB B:CYS96 3.4 47.5 1.0
CB A:CYS96 3.4 51.9 1.0
CA B:CYS101 3.7 49.0 1.0
CA A:CYS101 3.7 51.0 1.0
N B:GLY103 3.9 52.6 1.0
N A:GLY103 4.0 52.1 1.0
N B:LEU102 4.1 50.3 1.0
N A:LEU102 4.1 49.2 1.0
CA B:GLY103 4.2 51.0 1.0
C B:CYS101 4.2 48.6 1.0
CA A:GLY103 4.3 50.4 1.0
C A:CYS101 4.3 49.3 1.0
CA B:CYS96 4.8 51.0 1.0
CA A:CYS96 4.8 54.6 1.0
C B:LEU102 4.9 51.0 1.0
N A:CYS101 5.0 51.1 1.0
N B:CYS101 5.0 48.1 1.0
C A:LEU102 5.0 51.7 1.0

Reference:

G.Chreifi, H.Li, C.R.Mcinnes, C.L.Gibson, C.J.Suckling, T.L.Poulos. Communication Between the Zinc and Tetrahydrobiopterin Binding Sites in Nitric Oxide Synthase. Biochemistry V. 53 4216 2014.
ISSN: ISSN 0006-2960
PubMed: 24819538
DOI: 10.1021/BI5003986
Page generated: Wed Dec 16 05:09:35 2020

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