Atomistry » Zinc » PDB 4csh-4cxp » 4cty
Atomistry »
  Zinc »
    PDB 4csh-4cxp »
      4cty »

Zinc in PDB 4cty: Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (R)-6-(2-Amino-2-(3-(2-(6-Amino-4-Methylpyridin- 2-Yl)Ethyl)Phenyl)Ethyl)-4-Methylpyridin-2-Amine

Enzymatic activity of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (R)-6-(2-Amino-2-(3-(2-(6-Amino-4-Methylpyridin- 2-Yl)Ethyl)Phenyl)Ethyl)-4-Methylpyridin-2-Amine

All present enzymatic activity of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (R)-6-(2-Amino-2-(3-(2-(6-Amino-4-Methylpyridin- 2-Yl)Ethyl)Phenyl)Ethyl)-4-Methylpyridin-2-Amine:
1.14.13.39;

Protein crystallography data

The structure of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (R)-6-(2-Amino-2-(3-(2-(6-Amino-4-Methylpyridin- 2-Yl)Ethyl)Phenyl)Ethyl)-4-Methylpyridin-2-Amine, PDB code: 4cty was solved by G.Chreifi, H.Li, T.L.Poulos, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.22 / 2.30
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 57.852, 106.495, 156.755, 90.00, 90.00, 90.00
R / Rfree (%) 16.106 / 21.863

Other elements in 4cty:

The structure of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (R)-6-(2-Amino-2-(3-(2-(6-Amino-4-Methylpyridin- 2-Yl)Ethyl)Phenyl)Ethyl)-4-Methylpyridin-2-Amine also contains other interesting chemical elements:

Arsenic (As) 2 atoms
Iron (Fe) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (R)-6-(2-Amino-2-(3-(2-(6-Amino-4-Methylpyridin- 2-Yl)Ethyl)Phenyl)Ethyl)-4-Methylpyridin-2-Amine (pdb code 4cty). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (R)-6-(2-Amino-2-(3-(2-(6-Amino-4-Methylpyridin- 2-Yl)Ethyl)Phenyl)Ethyl)-4-Methylpyridin-2-Amine, PDB code: 4cty:

Zinc binding site 1 out of 1 in 4cty

Go back to Zinc Binding Sites List in 4cty
Zinc binding site 1 out of 1 in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (R)-6-(2-Amino-2-(3-(2-(6-Amino-4-Methylpyridin- 2-Yl)Ethyl)Phenyl)Ethyl)-4-Methylpyridin-2-Amine


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (R)-6-(2-Amino-2-(3-(2-(6-Amino-4-Methylpyridin- 2-Yl)Ethyl)Phenyl)Ethyl)-4-Methylpyridin-2-Amine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn900

b:31.3
occ:1.00
 SG B:CYS96 2.3 29.7 1.0
SG A:CYS101 2.3 27.6 1.0
SG B:CYS101 2.3 34.9 1.0
SG A:CYS96 2.4 27.7 1.0
CB A:CYS101 3.2 30.2 1.0
CB B:CYS101 3.2 34.0 1.0
CB A:CYS96 3.4 33.6 1.0
CB B:CYS96 3.4 31.0 1.0
CA B:CYS101 3.6 35.4 1.0
CA A:CYS101 3.7 31.8 1.0
N B:GLY103 3.9 41.5 1.0
N A:LEU102 4.1 32.5 1.0
N A:GLY103 4.1 35.2 1.0
N B:LEU102 4.1 38.5 1.0
C B:CYS101 4.3 36.4 1.0
C A:CYS101 4.3 31.2 1.0
CA B:GLY103 4.4 38.4 1.0
CA A:GLY103 4.4 34.0 1.0
CA A:CYS96 4.8 34.1 1.0
CA B:CYS96 4.8 31.7 1.0
N B:CYS101 4.9 33.6 1.0
C B:LEU102 4.9 38.0 1.0
C A:LEU102 5.0 34.4 1.0

Reference:

S.Kang, W.Tang, H.Li, G.Chreifi, P.Martasek, L.J.Roman, T.L.Poulos, R.B.Silverman. Nitric Oxide Synthase Inhibitors That Interact with Both A Heme Propionate and Tetrahydrobiopterin Show High Isoform Selectivity. J.Med.Chem. V. 57 4382 2014.
ISSN: ISSN 0022-2623
PubMed: 24758147
DOI: 10.1021/JM5004182
Page generated: Sat Oct 26 21:05:50 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy