Zinc in PDB 4ckv: Crystal Structure of Vegfr-1 Domain 2 in Presence of Zn

All present enzymatic activity of Crystal Structure of Vegfr-1 Domain 2 in Presence of Zn:
2.7.10.1;

The structure of Crystal Structure of Vegfr-1 Domain 2 in Presence of Zn, PDB code: 4ckv was solved by J.-F.Gaucher, M.Reille-Seroussi, N.Gagey-Eilstein, S.Broussy, P.Coric, B.Seijo, M.-B.Lascombe, B.Gautier, W.-Q.Liu, F.Huguenot, N.Inguimbert, S.Bouaziz, M.Vidal, I.Broutin, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.865 / 2.06
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	95.730, 102.390, 27.470, 90.00, 90.00, 90.00
R / Rfree (%)	16.28 / 20.53

The binding sites of Zinc atom in the Crystal Structure of Vegfr-1 Domain 2 in Presence of Zn (pdb code 4ckv). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Vegfr-1 Domain 2 in Presence of Zn, PDB code: 4ckv:

Zinc binding site 1 out of 1 in the Crystal Structure of Vegfr-1 Domain 2 in Presence of Zn


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Vegfr-1 Domain 2 in Presence of Zn within 5.0Å range: probe atom residue distance (Å) B Occ X:Zn1226 b:65.2 occ:1.00 NE2 X:HIS223 2.2 67.9 1.0 NE2 X:HIS147 2.3 62.3 1.0 CE1 X:HIS223 2.9 70.1 1.0 CD2 X:HIS147 3.1 60.3 1.0 CD2 X:HIS223 3.3 63.2 1.0 CE1 X:HIS147 3.4 61.2 1.0 ND1 X:HIS223 4.1 70.0 1.0 CG2 X:ILE145 4.3 31.9 1.0 CG X:HIS147 4.3 53.5 1.0 CG X:HIS223 4.3 66.2 1.0 ND1 X:HIS147 4.4 59.5 1.0 O X:HOH2019 4.6 86.6 1.0

J.-F.Gaucher, M.Reille-Seroussi, N.Gagey-Eilstein, S.Broussy, P.Coric, B.Seijo, M.-B.Lascombe, B.Gautier, W.-Q.Liu, F.Huguenot, N.Inguimbert, S.Bouaziz, M.Vidal, I.Broutin. The Structural Basis of Metal-Induced VEGFR1 Domain 2 Dimerization: Implication on Angiogenic Switch To Be Published.