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Zinc in PDB 4a7t: Structure of Human I113T SOD1 Mutant Complexed with Isoproteranol in the P21 Space Group

Enzymatic activity of Structure of Human I113T SOD1 Mutant Complexed with Isoproteranol in the P21 Space Group

All present enzymatic activity of Structure of Human I113T SOD1 Mutant Complexed with Isoproteranol in the P21 Space Group:
1.15.1.1;

Protein crystallography data

The structure of Structure of Human I113T SOD1 Mutant Complexed with Isoproteranol in the P21 Space Group, PDB code: 4a7t was solved by G.S.A.Wright, S.V.Antonyuk, N.M.Kershaw, R.W.Strange, S.S.Hasnain, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.14 / 1.45
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 37.890, 68.020, 49.310, 90.00, 103.95, 90.00
R / Rfree (%) 15.669 / 18.774

Other elements in 4a7t:

The structure of Structure of Human I113T SOD1 Mutant Complexed with Isoproteranol in the P21 Space Group also contains other interesting chemical elements:

Copper (Cu) 3 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of Human I113T SOD1 Mutant Complexed with Isoproteranol in the P21 Space Group (pdb code 4a7t). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of Human I113T SOD1 Mutant Complexed with Isoproteranol in the P21 Space Group, PDB code: 4a7t:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 4a7t

Go back to Zinc Binding Sites List in 4a7t
Zinc binding site 1 out of 2 in the Structure of Human I113T SOD1 Mutant Complexed with Isoproteranol in the P21 Space Group


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Human I113T SOD1 Mutant Complexed with Isoproteranol in the P21 Space Group within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1158

b:6.8
occ:1.00
OD1 A:ASP83 1.9 6.2 1.0
ND1 A:HIS63 2.0 5.3 1.0
ND1 A:HIS71 2.0 5.8 1.0
ND1 A:HIS80 2.0 4.5 1.0
CG A:ASP83 2.7 5.0 1.0
OD2 A:ASP83 2.8 6.3 1.0
CE1 A:HIS71 2.9 6.0 1.0
CE1 A:HIS80 2.9 4.5 1.0
CE1 A:HIS63 3.0 8.8 1.0
CG A:HIS63 3.0 6.2 1.0
CG A:HIS80 3.1 4.8 1.0
CG A:HIS71 3.2 5.5 1.0
CB A:HIS63 3.4 6.0 1.0
CB A:HIS80 3.6 4.9 1.0
CB A:HIS71 3.7 6.2 1.0
O A:LYS136 3.9 9.3 1.0
CA A:HIS71 4.0 6.8 1.0
NE2 A:HIS80 4.0 7.7 1.0
NE2 A:HIS71 4.1 6.8 1.0
NE2 A:HIS63 4.1 8.2 1.0
CB A:ASP83 4.1 4.4 1.0
CD2 A:HIS80 4.1 8.3 1.0
CD2 A:HIS63 4.2 8.5 1.0
CD2 A:HIS71 4.2 6.8 1.0
CA A:ASP83 4.7 4.7 1.0
N A:HIS80 4.7 6.3 1.0
N A:GLY72 4.7 6.0 1.0
CA A:HIS80 4.8 6.2 1.0
O A:HOH2091 4.9 12.4 1.0
CD2 A:HIS46 4.9 7.1 1.0
C A:HIS71 4.9 7.3 1.0
C A:LYS136 4.9 9.5 1.0
CA A:HIS63 4.9 6.3 1.0
N A:ASP83 5.0 5.9 1.0
N A:HIS71 5.0 7.7 1.0

Zinc binding site 2 out of 2 in 4a7t

Go back to Zinc Binding Sites List in 4a7t
Zinc binding site 2 out of 2 in the Structure of Human I113T SOD1 Mutant Complexed with Isoproteranol in the P21 Space Group


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Human I113T SOD1 Mutant Complexed with Isoproteranol in the P21 Space Group within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Zn1157

b:7.4
occ:1.00
OD1 F:ASP83 1.9 5.5 1.0
ND1 F:HIS63 2.0 6.2 1.0
ND1 F:HIS80 2.0 6.1 1.0
ND1 F:HIS71 2.1 7.1 1.0
CG F:ASP83 2.7 5.9 1.0
OD2 F:ASP83 2.8 6.8 1.0
CE1 F:HIS80 2.9 7.0 1.0
CE1 F:HIS71 2.9 9.2 1.0
CE1 F:HIS63 2.9 8.0 1.0
CG F:HIS63 3.0 6.1 1.0
CG F:HIS80 3.1 5.5 1.0
CG F:HIS71 3.2 6.5 1.0
CB F:HIS63 3.4 6.2 1.0
CB F:HIS80 3.6 4.6 1.0
CB F:HIS71 3.7 7.0 1.0
O F:LYS136 3.9 8.0 1.0
CA F:HIS71 3.9 6.5 1.0
NE2 F:HIS80 4.0 7.6 1.0
NE2 F:HIS63 4.1 9.1 1.0
NE2 F:HIS71 4.1 8.2 1.0
CD2 F:HIS80 4.1 5.5 1.0
CB F:ASP83 4.1 6.7 1.0
CD2 F:HIS63 4.1 8.8 1.0
CD2 F:HIS71 4.2 7.0 1.0
N F:GLY72 4.6 8.1 1.0
CA F:ASP83 4.7 7.7 1.0
N F:HIS80 4.8 6.3 1.0
CD2 F:HIS46 4.8 7.8 1.0
CA F:HIS80 4.8 5.8 1.0
C F:HIS71 4.8 8.0 1.0
C F:LYS136 4.9 9.1 1.0
O F:HOH2067 4.9 12.1 1.0
CA F:HIS63 4.9 6.1 1.0
N F:HIS71 5.0 8.5 1.0
N F:ASP83 5.0 7.5 1.0
O F:GLY72 5.0 8.0 1.0

Reference:

G.S.A.Wright, S.V.Antonyuk, N.M.Kershaw, R.W.Strange, S.S.Hasnain. Ligand Binding and Aggregation of Pathogenic SOD1. Nat.Commun. V. 4 1758 2013.
ISSN: ISSN 2041-1723
PubMed: 23612299
DOI: 10.1038/NCOMMS2750
Page generated: Sat Oct 26 19:06:23 2024

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