Zinc in PDB 3zg6: The Novel De-Long Chain Fatty Acid Function of Human SIRT6

All present enzymatic activity of The Novel De-Long Chain Fatty Acid Function of Human SIRT6:
2.4.2.31;

The structure of The Novel De-Long Chain Fatty Acid Function of Human SIRT6, PDB code: 3zg6 was solved by Y.Wang, Q.Hao, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	35.73 / 2.20
Space group	H 3 2
Cell size a, b, c (Å), α, β, γ (°)	104.891, 104.891, 231.492, 90.00, 90.00, 120.00
R / Rfree (%)	19.112 / 23.581

The binding sites of Zinc atom in the The Novel De-Long Chain Fatty Acid Function of Human SIRT6 (pdb code 3zg6). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the The Novel De-Long Chain Fatty Acid Function of Human SIRT6, PDB code: 3zg6:

Zinc binding site 1 out of 1 in the The Novel De-Long Chain Fatty Acid Function of Human SIRT6


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of The Novel De-Long Chain Fatty Acid Function of Human SIRT6 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1295 b:49.9 occ:1.00 SG A:CYS142 2.2 49.4 1.0 SG A:CYS164 2.2 47.3 1.0 SG A:CYS175 2.4 56.0 1.0 SG A:CYS139 2.4 50.4 1.0 CB A:CYS164 3.0 49.8 1.0 CB A:CYS175 3.1 53.8 1.0 CB A:CYS139 3.1 45.6 1.0 CB A:CYS142 3.2 54.8 1.0 N A:CYS142 3.8 56.7 1.0 CA A:CYS142 4.1 55.6 1.0 CB A:LYS141 4.4 59.8 1.0 CA A:CYS164 4.5 50.6 1.0 N A:GLY177 4.5 51.2 1.0 CA A:CYS175 4.6 54.9 1.0 CA A:CYS139 4.6 46.5 1.0 CG2 A:THR144 4.6 46.0 1.0 C A:CYS142 4.7 55.4 1.0 CA A:GLY177 4.7 50.4 1.0 CB A:VAL166 4.8 55.5 1.0 C A:LYS141 4.9 58.0 1.0

H.Jiang, S.Khan, Y.Wang, G.Charron, B.He, C.Sebastian, J.Du, R.Kim, E.Ge, R.Mostoslavsky, H.C.Hang, Q.Hao, H.Lin. SIRT6 Regulates Tnf-Alpha Secretion Through Hydrolysis of Long-Chain Fatty Acyl Lysine Nature V. 496 110 2013.
ISSN: ISSN 0028-0836
PubMed: 23552949
DOI: 10.1038/NATURE12038