Zinc in PDB 3vow: Crystal Structure of the Human APOBEC3C Having Hiv-1 Vif-Binding Interface

The structure of Crystal Structure of the Human APOBEC3C Having Hiv-1 Vif-Binding Interface, PDB code: 3vow was solved by S.Kitamura, A.Suzuki, N.Watanabe, Y.Iwatani, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	90.97 / 2.15
Space group	P 61
Cell size a, b, c (Å), α, β, γ (°)	105.042, 105.042, 70.046, 90.00, 90.00, 120.00
R / Rfree (%)	21.4 / 26.3

The structure of Crystal Structure of the Human APOBEC3C Having Hiv-1 Vif-Binding Interface also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Zinc atom in the Crystal Structure of the Human APOBEC3C Having Hiv-1 Vif-Binding Interface (pdb code 3vow). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of the Human APOBEC3C Having Hiv-1 Vif-Binding Interface, PDB code: 3vow:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of the Human APOBEC3C Having Hiv-1 Vif-Binding Interface


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Human APOBEC3C Having Hiv-1 Vif-Binding Interface within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn201 b:41.5 occ:1.00 ND1 A:HIS66 2.0 50.0 1.0 SG A:CYS100 2.1 39.1 1.0 O A:HOH331 2.3 40.5 1.0 SG A:CYS97 2.6 51.9 1.0 CE1 A:HIS66 2.9 48.0 1.0 CG A:HIS66 3.0 44.1 1.0 CB A:CYS100 3.1 40.8 1.0 CB A:HIS66 3.4 42.9 1.0 OE1 A:GLU68 3.8 43.7 1.0 CB A:CYS97 3.8 47.7 1.0 N A:CYS97 3.9 45.3 1.0 N A:CYS100 4.0 42.5 1.0 NE2 A:HIS66 4.1 43.0 1.0 CA A:CYS100 4.1 37.4 1.0 CD2 A:HIS66 4.1 43.8 1.0 OE2 A:GLU68 4.1 42.1 1.0 CD A:GLU68 4.2 39.8 1.0 CA A:CYS97 4.4 43.3 1.0 O A:CYS97 4.5 37.8 1.0 O A:THR63 4.6 41.6 1.0 C A:CYS97 4.7 38.9 1.0 CA A:HIS66 4.9 41.3 1.0 C A:PRO96 5.0 40.9 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of the Human APOBEC3C Having Hiv-1 Vif-Binding Interface


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the Human APOBEC3C Having Hiv-1 Vif-Binding Interface within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn201 b:50.6 occ:1.00 ND1 B:HIS66 1.9 48.4 1.0 O B:HOH332 2.0 53.4 1.0 SG B:CYS100 2.1 54.9 1.0 SG B:CYS97 2.4 57.2 1.0 CE1 B:HIS66 2.7 52.5 1.0 CG B:HIS66 3.0 50.6 1.0 CB B:CYS100 3.1 49.5 1.0 CB B:CYS97 3.2 52.0 1.0 CB B:HIS66 3.5 44.9 1.0 N B:CYS97 3.9 53.7 1.0 NE2 B:HIS66 3.9 52.1 1.0 CD2 B:HIS66 4.0 50.3 1.0 N B:CYS100 4.0 46.0 1.0 OE1 B:GLU68 4.1 48.6 1.0 CA B:CYS97 4.1 54.9 1.0 CA B:CYS100 4.1 47.4 1.0 OE2 B:GLU68 4.3 40.0 1.0 CD B:GLU68 4.3 42.9 1.0 O B:HOH312 4.3 47.8 1.0 O B:CYS97 4.6 60.0 1.0 C B:CYS97 4.7 56.3 1.0 CA B:HIS66 4.9 44.8 1.0

S.Kitamura, H.Ode, M.Nakashima, M.Imahashi, Y.Naganawa, T.Kurosawa, Y.Yokomaku, T.Yamane, N.Watanabe, A.Suzuki, W.Sugiura, Y.Iwatani. The APOBEC3C Crystal Structure and the Interface For Hiv-1 Vif Binding. Nat.Struct.Mol.Biol. V. 19 1005 2012.
ISSN: ISSN 1545-9993
PubMed: 23001005
DOI: 10.1038/NSMB.2378