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Zinc in PDB 3v96: Complex of Matrix Metalloproteinase-10 Catalytic Domain (Mmp-10CD) with Tissue Inhibitor of Metalloproteinases-1 (Timp-1)

Enzymatic activity of Complex of Matrix Metalloproteinase-10 Catalytic Domain (Mmp-10CD) with Tissue Inhibitor of Metalloproteinases-1 (Timp-1)

All present enzymatic activity of Complex of Matrix Metalloproteinase-10 Catalytic Domain (Mmp-10CD) with Tissue Inhibitor of Metalloproteinases-1 (Timp-1):
3.4.24.22;

Protein crystallography data

The structure of Complex of Matrix Metalloproteinase-10 Catalytic Domain (Mmp-10CD) with Tissue Inhibitor of Metalloproteinases-1 (Timp-1), PDB code: 3v96 was solved by J.Batra, A.S.Soares, E.S.Radisky, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 35.00 / 1.90
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 231.720, 37.682, 39.523, 90.00, 90.00, 90.00
R / Rfree (%) 21.5 / 26.6

Other elements in 3v96:

The structure of Complex of Matrix Metalloproteinase-10 Catalytic Domain (Mmp-10CD) with Tissue Inhibitor of Metalloproteinases-1 (Timp-1) also contains other interesting chemical elements:

Calcium (Ca) 3 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Complex of Matrix Metalloproteinase-10 Catalytic Domain (Mmp-10CD) with Tissue Inhibitor of Metalloproteinases-1 (Timp-1) (pdb code 3v96). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Complex of Matrix Metalloproteinase-10 Catalytic Domain (Mmp-10CD) with Tissue Inhibitor of Metalloproteinases-1 (Timp-1), PDB code: 3v96:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 3v96

Go back to Zinc Binding Sites List in 3v96
Zinc binding site 1 out of 2 in the Complex of Matrix Metalloproteinase-10 Catalytic Domain (Mmp-10CD) with Tissue Inhibitor of Metalloproteinases-1 (Timp-1)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Complex of Matrix Metalloproteinase-10 Catalytic Domain (Mmp-10CD) with Tissue Inhibitor of Metalloproteinases-1 (Timp-1) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn301

b:22.2
occ:1.00
 NE2 B:HIS227 2.0 17.7 1.0
N A:CYS1 2.0 23.8 1.0
NE2 B:HIS221 2.1 20.2 1.0
NE2 B:HIS217 2.1 15.6 1.0
O A:CYS1 2.3 22.2 1.0
CD2 B:HIS217 2.9 19.8 1.0
CD2 B:HIS227 2.9 21.8 1.0
C A:CYS1 3.0 22.8 1.0
CD2 B:HIS221 3.0 19.0 1.0
CA A:CYS1 3.0 22.7 1.0
CE1 B:HIS227 3.1 19.4 1.0
CE1 B:HIS221 3.1 25.8 1.0
CE1 B:HIS217 3.2 21.3 1.0
CB A:CYS1 3.8 22.4 1.0
OE2 B:GLU218 4.1 25.5 1.0
CG B:HIS227 4.1 18.6 1.0
CG B:HIS217 4.1 17.2 1.0
ND1 B:HIS227 4.1 15.5 1.0
N A:THR2 4.2 23.1 1.0
CG B:HIS221 4.2 18.2 1.0
OE1 B:GLU218 4.2 21.4 1.0
ND1 B:HIS221 4.2 22.7 1.0
ND1 B:HIS217 4.2 15.6 1.0
CD B:GLU218 4.5 22.0 1.0
O A:GLU67 4.6 23.4 1.0
OG1 A:THR2 4.7 26.4 1.0
CE B:MET235 4.8 18.9 1.0
CA A:THR2 4.9 23.0 1.0
CA A:SER68 4.9 23.7 1.0
O A:SER68 4.9 24.4 1.0
CA B:PRO237 4.9 25.8 1.0
O B:HOH433 5.0 37.7 1.0

Zinc binding site 2 out of 2 in 3v96

Go back to Zinc Binding Sites List in 3v96
Zinc binding site 2 out of 2 in the Complex of Matrix Metalloproteinase-10 Catalytic Domain (Mmp-10CD) with Tissue Inhibitor of Metalloproteinases-1 (Timp-1)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Complex of Matrix Metalloproteinase-10 Catalytic Domain (Mmp-10CD) with Tissue Inhibitor of Metalloproteinases-1 (Timp-1) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn302

b:42.6
occ:1.00
 OD2 B:ASP169 1.7 40.0 1.0
NE2 B:HIS167 2.0 44.1 1.0
NE2 B:HIS182 2.1 42.4 1.0
ND1 B:HIS195 2.2 38.6 1.0
CG B:ASP169 2.6 47.9 1.0
CE1 B:HIS182 2.9 37.5 1.0
OD1 B:ASP169 2.9 48.5 1.0
CD2 B:HIS167 3.0 46.2 1.0
CE1 B:HIS167 3.0 45.2 1.0
CE1 B:HIS195 3.1 40.5 1.0
CD2 B:HIS182 3.2 33.1 1.0
CG B:HIS195 3.2 36.9 1.0
CB B:HIS195 3.5 37.1 1.0
CB B:ASP169 4.0 51.1 1.0
OH B:TYR184 4.0 33.9 1.0
ND1 B:HIS182 4.1 32.6 1.0
ND1 B:HIS167 4.1 47.4 1.0
CG B:HIS167 4.1 49.1 1.0
NE2 B:HIS195 4.2 39.6 1.0
CG B:HIS182 4.2 30.2 1.0
CD2 B:HIS195 4.3 39.5 1.0
O B:TYR171 4.3 41.9 1.0
CE1 B:PHE173 4.6 39.7 1.0
CE1 B:TYR184 4.6 34.6 1.0
CZ B:PHE173 4.7 36.8 1.0
O B:HOH467 4.8 58.9 1.0
CZ B:TYR184 4.8 33.0 1.0
CA B:HIS195 5.0 35.9 1.0

Reference:

J.Batra, J.Robinson, A.S.Soares, A.P.Fields, D.C.Radisky, E.S.Radisky. Matrix Metalloproteinase-10 (Mmp-10) Interaction with Tissue Inhibitors of Metalloproteinases Timp-1 and Timp-2: Binding Studies and Crystal Structure. J.Biol.Chem. V. 287 15935 2012.
ISSN: ISSN 0021-9258
PubMed: 22427646
DOI: 10.1074/JBC.M112.341156
Page generated: Sat Oct 26 17:37:54 2024

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