Zinc in PDB 3usn: Structure of the Catalytic Domain of Human Fibroblast Stromelysin-1 Inhibited with the Thiadiazole Inhibitor Ipnu-107859, uc(Nmr), 1 Structure

Enzymatic activity of Structure of the Catalytic Domain of Human Fibroblast Stromelysin-1 Inhibited with the Thiadiazole Inhibitor Ipnu-107859, uc(Nmr), 1 Structure

Other elements in 3usn:

Zinc Binding Sites:

Zinc binding site 1 out of 2 in 3usn

Zinc Binding Sites List in 3usn

Zinc binding site 1 out of 2 in the Structure of the Catalytic Domain of Human Fibroblast Stromelysin-1 Inhibited with the Thiadiazole Inhibitor Ipnu-107859, uc(Nmr), 1 Structure


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of the Catalytic Domain of Human Fibroblast Stromelysin-1 Inhibited with the Thiadiazole Inhibitor Ipnu-107859, uc(Nmr), 1 Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn169 b:0.0 occ:1.00 NE2 A:HIS119 2.6 0.0 1.0 NE2 A:HIS123 2.6 0.0 1.0 NE2 A:HIS129 2.6 0.0 1.0 S2 A:ATT174 2.7 0.0 1.0 HE1 A:HIS119 3.0 0.0 1.0 C12 A:ATT174 3.2 0.0 1.0 CE1 A:HIS119 3.2 0.0 1.0 CD2 A:HIS123 3.4 0.0 1.0 S1 A:ATT174 3.5 0.0 1.0 HD2 A:HIS123 3.5 0.0 1.0 CE1 A:HIS129 3.6 0.0 1.0 CE1 A:HIS123 3.6 0.0 1.0 CD2 A:HIS129 3.6 0.0 1.0 HE1 A:HIS129 3.7 0.0 1.0 HA A:PRO139 3.7 0.0 1.0 CD2 A:HIS119 3.7 0.0 1.0 OE1 A:GLU120 3.8 0.0 1.0 HD2 A:HIS129 3.8 0.0 1.0 HE1 A:HIS123 3.9 0.0 1.0 HD2 A:HIS119 4.2 0.0 1.0 N3 A:ATT174 4.2 0.0 1.0 HD13 A:LEU82 4.4 0.0 1.0 ND1 A:HIS119 4.4 0.0 1.0 HE2 A:GLU120 4.4 0.0 1.0 O A:PRO139 4.6 0.0 1.0 CG A:HIS123 4.6 0.0 1.0 CG A:HIS119 4.7 0.0 1.0 ND1 A:HIS123 4.7 0.0 1.0 CA A:PRO139 4.8 0.0 1.0 O A:TYR138 4.8 0.0 1.0 C11 A:ATT174 4.8 0.0 1.0 CG A:HIS129 4.8 0.0 1.0 ND1 A:HIS129 4.8 0.0 1.0 CD A:GLU120 4.8 0.0 1.0 HE2 A:MET137 4.8 0.0 1.0 N4 A:ATT174 4.9 0.0 1.0 C A:PRO139 5.0 0.0 1.0

Zinc binding site 2 out of 2 in 3usn

Zinc Binding Sites List in 3usn

Zinc binding site 2 out of 2 in the Structure of the Catalytic Domain of Human Fibroblast Stromelysin-1 Inhibited with the Thiadiazole Inhibitor Ipnu-107859, uc(Nmr), 1 Structure


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of the Catalytic Domain of Human Fibroblast Stromelysin-1 Inhibited with the Thiadiazole Inhibitor Ipnu-107859, uc(Nmr), 1 Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn170 b:0.0 occ:1.00 HD2 A:ASP71 2.0 0.0 1.0 OD2 A:ASP71 2.3 0.0 1.0 HE2 A:TYR86 2.5 0.0 1.0 NE2 A:HIS69 2.6 0.0 1.0 ND1 A:HIS97 2.6 0.0 1.0 NE2 A:HIS84 2.6 0.0 1.0 HE1 A:HIS69 2.7 0.0 1.0 CE1 A:HIS97 2.8 0.0 1.0 HD2 A:HIS84 2.8 0.0 1.0 CG A:HIS97 2.9 0.0 1.0 CG A:ASP71 3.0 0.0 1.0 CE1 A:HIS69 3.0 0.0 1.0 CD2 A:HIS84 3.1 0.0 1.0 HE1 A:HIS97 3.3 0.0 1.0 NE2 A:HIS97 3.3 0.0 1.0 CD2 A:HIS97 3.3 0.0 1.0 HH A:TYR86 3.5 0.0 1.0 OD1 A:ASP71 3.5 0.0 1.0 HB3 A:HIS97 3.5 0.0 1.0 CE2 A:TYR86 3.6 0.0 1.0 HB2 A:HIS97 3.6 0.0 1.0 CB A:HIS97 3.6 0.0 1.0 HB3 A:ASP71 3.7 0.0 1.0 CB A:ASP71 3.9 0.0 1.0 CD2 A:HIS69 3.9 0.0 1.0 CE1 A:HIS84 3.9 0.0 1.0 HD2 A:HIS97 4.0 0.0 1.0 HE2 A:HIS97 4.0 0.0 1.0 HB2 A:ASP71 4.1 0.0 1.0 OH A:TYR86 4.2 0.0 1.0 ND1 A:HIS69 4.3 0.0 1.0 CZ A:TYR86 4.4 0.0 1.0 HD2 A:TYR86 4.4 0.0 1.0 HE1 A:HIS84 4.4 0.0 1.0 CG A:HIS84 4.5 0.0 1.0 CD2 A:TYR86 4.5 0.0 1.0 HD2 A:HIS69 4.5 0.0 1.0 CG A:HIS69 4.7 0.0 1.0 ND1 A:HIS84 4.9 0.0 1.0 HD1 A:HIS69 5.0 0.0 1.0

Reference: