Zinc in PDB 3n57: Crystal Structure of Human Insulin-Degrading Enzyme (Ide) in Complex with Human Atrial Natriuretic Peptide (Anp)

All present enzymatic activity of Crystal Structure of Human Insulin-Degrading Enzyme (Ide) in Complex with Human Atrial Natriuretic Peptide (Anp):
3.4.24.56;

The structure of Crystal Structure of Human Insulin-Degrading Enzyme (Ide) in Complex with Human Atrial Natriuretic Peptide (Anp), PDB code: 3n57 was solved by T.Funke, Q.Guo, W.-J.Tang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.96 / 3.03
Space group	P 65
Cell size a, b, c (Å), α, β, γ (°)	264.101, 264.101, 91.186, 90.00, 90.00, 120.00
R / Rfree (%)	20.6 / 24.2

The binding sites of Zinc atom in the Crystal Structure of Human Insulin-Degrading Enzyme (Ide) in Complex with Human Atrial Natriuretic Peptide (Anp) (pdb code 3n57). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Human Insulin-Degrading Enzyme (Ide) in Complex with Human Atrial Natriuretic Peptide (Anp), PDB code: 3n57:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Human Insulin-Degrading Enzyme (Ide) in Complex with Human Atrial Natriuretic Peptide (Anp)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human Insulin-Degrading Enzyme (Ide) in Complex with Human Atrial Natriuretic Peptide (Anp) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1 b:63.9 occ:1.00 OE1 A:GLU189 2.0 41.8 1.0 NE2 A:HIS112 2.0 37.8 1.0 NE2 A:HIS108 2.1 33.3 1.0 CE1 A:HIS108 2.8 33.3 1.0 CE1 A:HIS112 2.8 37.1 1.0 CD A:GLU189 2.9 40.3 1.0 OE2 A:GLU189 3.2 41.6 1.0 CD2 A:HIS112 3.2 37.6 1.0 CD2 A:HIS108 3.2 33.3 1.0 ND1 A:HIS108 3.9 33.3 1.0 ND1 A:HIS112 4.0 36.6 1.0 CG A:HIS112 4.2 36.4 1.0 CG A:HIS108 4.2 32.5 1.0 CG A:GLU189 4.3 37.5 1.0 OH A:TYR831 4.4 37.7 1.0 CE1 A:TYR831 4.4 36.6 1.0 CB A:GLU189 4.7 35.7 1.0 NE2 A:GLN111 4.8 31.1 1.0 OE1 A:GLN111 4.8 32.2 1.0 CZ A:TYR831 4.8 36.7 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Human Insulin-Degrading Enzyme (Ide) in Complex with Human Atrial Natriuretic Peptide (Anp)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Human Insulin-Degrading Enzyme (Ide) in Complex with Human Atrial Natriuretic Peptide (Anp) within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn2 b:69.4 occ:1.00 OE2 B:GLU189 1.7 31.9 1.0 NE2 B:HIS108 2.3 31.6 1.0 NE2 B:HIS112 2.3 28.4 1.0 CD B:GLU189 2.7 32.7 1.0 OE1 B:GLU189 3.1 31.5 1.0 CD2 B:HIS108 3.2 31.8 1.0 CE1 B:HIS112 3.2 28.9 1.0 CD2 B:HIS112 3.3 29.0 1.0 CE1 B:HIS108 3.3 32.1 1.0 NE2 B:GLN111 3.9 33.9 1.0 CG B:GLU189 4.0 33.6 1.0 ND1 B:HIS112 4.3 29.4 1.0 CG B:HIS108 4.4 31.1 1.0 ND1 B:HIS108 4.4 31.5 1.0 CG B:HIS112 4.4 29.9 1.0 OE1 B:GLN111 4.4 34.9 1.0 OH B:TYR831 4.4 31.7 1.0 CD B:GLN111 4.5 34.2 1.0 CE1 B:TYR831 4.7 30.8 1.0 CZ B:TYR831 5.0 31.1 1.0

L.A.Ralat, T.Funke, M.Ren, Q.Guo, D.M.Dickey, L.R.Potter, W.-J.Tang. Crystal Structure of Human Insulin-Degrading Enzyme (Ide) in Complex with Human Atrial Natriuretic Peptide (Anp) To Be Published.