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Zinc in PDB 3dx0: Golgi Alpha-Mannosidase II in Complex with Mannostatin A at pH 5.75

Enzymatic activity of Golgi Alpha-Mannosidase II in Complex with Mannostatin A at pH 5.75

All present enzymatic activity of Golgi Alpha-Mannosidase II in Complex with Mannostatin A at pH 5.75:
3.2.1.114;

Protein crystallography data

The structure of Golgi Alpha-Mannosidase II in Complex with Mannostatin A at pH 5.75, PDB code: 3dx0 was solved by D.A.Kuntz, D.R.Rose, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.57 / 1.70
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 68.853, 109.860, 139.136, 90.00, 90.00, 90.00
R / Rfree (%) 16 / 18.6

Zinc Binding Sites:

The binding sites of Zinc atom in the Golgi Alpha-Mannosidase II in Complex with Mannostatin A at pH 5.75 (pdb code 3dx0). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Golgi Alpha-Mannosidase II in Complex with Mannostatin A at pH 5.75, PDB code: 3dx0:

Zinc binding site 1 out of 1 in 3dx0

Go back to Zinc Binding Sites List in 3dx0
Zinc binding site 1 out of 1 in the Golgi Alpha-Mannosidase II in Complex with Mannostatin A at pH 5.75


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Golgi Alpha-Mannosidase II in Complex with Mannostatin A at pH 5.75 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1047

b:7.9
occ:1.00
NE2 A:HIS471 2.1 7.3 1.0
NE2 A:HIS90 2.1 4.1 1.0
OD2 A:ASP204 2.1 5.0 1.0
O4 A:MSN1049 2.2 6.0 1.0
OD1 A:ASP92 2.2 6.2 1.0
O3 A:MSN1049 2.2 6.2 1.0
CD2 A:HIS90 3.0 4.6 1.0
CE1 A:HIS471 3.1 3.8 1.0
C4 A:MSN1049 3.1 7.2 1.0
CD2 A:HIS471 3.1 7.3 1.0
C3 A:MSN1049 3.1 7.5 1.0
CG A:ASP204 3.1 5.7 1.0
CE1 A:HIS90 3.2 4.8 1.0
CG A:ASP92 3.2 7.4 1.0
OD2 A:ASP92 3.5 7.8 1.0
CB A:ASP204 3.6 5.5 1.0
C5 A:MSN1049 3.9 7.7 1.0
N5 A:MSN1049 4.0 7.7 1.0
OD2 A:ASP472 4.1 6.9 1.0
C1 A:MSN1049 4.1 9.0 1.0
ND1 A:HIS471 4.2 6.1 1.0
CG A:HIS90 4.2 4.7 1.0
CG A:HIS471 4.2 5.0 1.0
ND1 A:HIS90 4.2 7.6 1.0
OD1 A:ASP204 4.3 5.0 1.0
C2 A:MSN1049 4.3 7.9 1.0
CE1 A:HIS470 4.5 6.9 1.0
CB A:ASP92 4.5 6.2 1.0
OH A:TYR269 4.7 8.6 1.0
O A:HOH1885 4.7 7.5 1.0
O2 A:MSN1049 4.8 8.3 1.0

Reference:

D.A.Kuntz, W.Zhong, J.Guo, D.R.Rose, G.J.Boons. The Molecular Basis of Inhibition of Golgi Alpha-Mannosidase II By Mannostatin A. Chembiochem V. 10 268 2009.
ISSN: ISSN 1439-4227
PubMed: 19101978
DOI: 10.1002/CBIC.200800538
Page generated: Sat Sep 26 06:04:24 2020
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