Zinc in PDB 3dx0: Golgi Alpha-Mannosidase II in Complex with Mannostatin A at pH 5.75

All present enzymatic activity of Golgi Alpha-Mannosidase II in Complex with Mannostatin A at pH 5.75:
3.2.1.114;

The structure of Golgi Alpha-Mannosidase II in Complex with Mannostatin A at pH 5.75, PDB code: 3dx0 was solved by D.A.Kuntz, D.R.Rose, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.57 / 1.70
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	68.853, 109.860, 139.136, 90.00, 90.00, 90.00
R / Rfree (%)	16 / 18.6

The binding sites of Zinc atom in the Golgi Alpha-Mannosidase II in Complex with Mannostatin A at pH 5.75 (pdb code 3dx0). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Golgi Alpha-Mannosidase II in Complex with Mannostatin A at pH 5.75, PDB code: 3dx0:

Zinc binding site 1 out of 1 in the Golgi Alpha-Mannosidase II in Complex with Mannostatin A at pH 5.75


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Golgi Alpha-Mannosidase II in Complex with Mannostatin A at pH 5.75 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1047 b:7.9 occ:1.00 NE2 A:HIS471 2.1 7.3 1.0 NE2 A:HIS90 2.1 4.1 1.0 OD2 A:ASP204 2.1 5.0 1.0 O4 A:MSN1049 2.2 6.0 1.0 OD1 A:ASP92 2.2 6.2 1.0 O3 A:MSN1049 2.2 6.2 1.0 CD2 A:HIS90 3.0 4.6 1.0 CE1 A:HIS471 3.1 3.8 1.0 C4 A:MSN1049 3.1 7.2 1.0 CD2 A:HIS471 3.1 7.3 1.0 C3 A:MSN1049 3.1 7.5 1.0 CG A:ASP204 3.1 5.7 1.0 CE1 A:HIS90 3.2 4.8 1.0 CG A:ASP92 3.2 7.4 1.0 OD2 A:ASP92 3.5 7.8 1.0 CB A:ASP204 3.6 5.5 1.0 C5 A:MSN1049 3.9 7.7 1.0 N5 A:MSN1049 4.0 7.7 1.0 OD2 A:ASP472 4.1 6.9 1.0 C1 A:MSN1049 4.1 9.0 1.0 ND1 A:HIS471 4.2 6.1 1.0 CG A:HIS90 4.2 4.7 1.0 CG A:HIS471 4.2 5.0 1.0 ND1 A:HIS90 4.2 7.6 1.0 OD1 A:ASP204 4.3 5.0 1.0 C2 A:MSN1049 4.3 7.9 1.0 CE1 A:HIS470 4.5 6.9 1.0 CB A:ASP92 4.5 6.2 1.0 OH A:TYR269 4.7 8.6 1.0 O A:HOH1885 4.7 7.5 1.0 O2 A:MSN1049 4.8 8.3 1.0

D.A.Kuntz, W.Zhong, J.Guo, D.R.Rose, G.J.Boons. The Molecular Basis of Inhibition of Golgi Alpha-Mannosidase II By Mannostatin A. Chembiochem V. 10 268 2009.
ISSN: ISSN 1439-4227
PubMed: 19101978
DOI: 10.1002/CBIC.200800538