Zinc in PDB 2vit: Influenza Virus Hemagglutinin, Mutant with Thr 155 Replaced By Ile, Complexed with A Neutralizing Antibody

The structure of Influenza Virus Hemagglutinin, Mutant with Thr 155 Replaced By Ile, Complexed with A Neutralizing Antibody, PDB code: 2vit was solved by T.Bizebard, D.Fleury, B.Gigant, S.A.Wharton, J.J.Skehel, M.Knossow, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	7.00 / 3.25
Space group	P 61 2 2
Cell size a, b, c (Å), α, β, γ (°)	85.500, 85.500, 515.000, 90.00, 90.00, 120.00
R / Rfree (%)	18.8 / 23.7

The binding sites of Zinc atom in the Influenza Virus Hemagglutinin, Mutant with Thr 155 Replaced By Ile, Complexed with A Neutralizing Antibody (pdb code 2vit). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Influenza Virus Hemagglutinin, Mutant with Thr 155 Replaced By Ile, Complexed with A Neutralizing Antibody, PDB code: 2vit:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the Influenza Virus Hemagglutinin, Mutant with Thr 155 Replaced By Ile, Complexed with A Neutralizing Antibody


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Influenza Virus Hemagglutinin, Mutant with Thr 155 Replaced By Ile, Complexed with A Neutralizing Antibody within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn1 b:43.6 occ:1.00 NE2 C:HIS56 1.8 33.3 1.0 OE2 C:GLU280 2.0 28.6 1.0 CD2 C:HIS56 2.7 31.0 1.0 CD C:GLU280 2.7 26.0 1.0 OE1 C:GLU280 2.8 24.3 1.0 CE1 C:HIS56 2.9 30.8 1.0 CG C:HIS56 3.9 30.6 1.0 ND1 C:HIS56 3.9 30.1 1.0 CA C:GLY303 4.2 32.8 1.0 CG C:GLU280 4.2 25.4 1.0 O C:GLU280 4.3 32.4 1.0 N C:ALA304 4.6 31.2 1.0 C C:GLY303 5.0 33.2 1.0

Zinc binding site 2 out of 3 in the Influenza Virus Hemagglutinin, Mutant with Thr 155 Replaced By Ile, Complexed with A Neutralizing Antibody


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Influenza Virus Hemagglutinin, Mutant with Thr 155 Replaced By Ile, Complexed with A Neutralizing Antibody within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn211 b:44.3 occ:1.00 OD2 A:ASP154 1.8 18.2 1.0 ND1 A:HIS191 2.0 34.3 1.0 CE1 A:HIS191 2.8 33.8 1.0 CG A:ASP154 2.9 22.6 1.0 CG A:HIS191 3.2 30.5 1.0 CB A:ASP154 3.5 19.7 1.0 CB A:HIS191 3.7 28.1 1.0 O A:ARG190 3.8 38.3 1.0 OD1 A:ASP154 3.9 27.1 1.0 CA A:HIS191 4.0 31.3 1.0 NE2 A:HIS191 4.0 32.5 1.0 CD2 A:HIS191 4.2 31.8 1.0 C A:ARG190 4.7 36.9 1.0 N A:HIS191 4.8 34.3 1.0 N A:SER192 4.9 33.9 1.0 CG1 A:VAL153 4.9 19.3 1.0 CA A:ASP154 5.0 18.8 1.0

Zinc binding site 3 out of 3 in the Influenza Virus Hemagglutinin, Mutant with Thr 155 Replaced By Ile, Complexed with A Neutralizing Antibody


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Influenza Virus Hemagglutinin, Mutant with Thr 155 Replaced By Ile, Complexed with A Neutralizing Antibody within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn212 b:0.5 occ:1.00 NE2 B:HIS173 2.3 49.4 1.0 OD2 A:ASP141 2.4 38.9 1.0 OD1 A:ASP141 3.1 32.9 1.0 CG A:ASP141 3.1 34.0 1.0 CE1 B:HIS173 3.1 47.2 1.0 CD2 B:HIS173 3.4 44.0 1.0 ND1 B:HIS173 4.3 44.6 1.0 CG B:HIS173 4.5 40.4 1.0 CB A:ASP141 4.5 27.4 1.0 CA B:GLY171 4.6 48.2 1.0 NE2 A:GLN170 4.7 23.2 1.0 OG1 A:THR140 4.7 14.4 1.0

D.Fleury, S.A.Wharton, J.J.Skehel, M.Knossow, T.Bizebard. Antigen Distortion Allows Influenza Virus to Escape Neutralization. Nat.Struct.Biol. V. 5 119 1998.
ISSN: ISSN 1072-8368
PubMed: 9461077
DOI: 10.1038/NSB0298-119