Zinc in PDB 2vis: Influenza Virus Hemagglutinin, (Escape) Mutant with Thr 131 Replaced By Ile, Complexed with A Neutralizing Antibody

The structure of Influenza Virus Hemagglutinin, (Escape) Mutant with Thr 131 Replaced By Ile, Complexed with A Neutralizing Antibody, PDB code: 2vis was solved by T.Bizebard, D.Fleury, B.Gigant, S.A.Wharton, J.J.Skehel, M.Knossow, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	7.00 / 3.25
Space group	P 61 2 2
Cell size a, b, c (Å), α, β, γ (°)	85.500, 85.500, 515.000, 90.00, 90.00, 120.00
R / Rfree (%)	18.8 / 26.7

The binding sites of Zinc atom in the Influenza Virus Hemagglutinin, (Escape) Mutant with Thr 131 Replaced By Ile, Complexed with A Neutralizing Antibody (pdb code 2vis). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Influenza Virus Hemagglutinin, (Escape) Mutant with Thr 131 Replaced By Ile, Complexed with A Neutralizing Antibody, PDB code: 2vis:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the Influenza Virus Hemagglutinin, (Escape) Mutant with Thr 131 Replaced By Ile, Complexed with A Neutralizing Antibody


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Influenza Virus Hemagglutinin, (Escape) Mutant with Thr 131 Replaced By Ile, Complexed with A Neutralizing Antibody within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn1 b:41.2 occ:1.00 NE2 C:HIS56 1.8 32.4 1.0 OE2 C:GLU280 2.1 26.4 1.0 CD C:GLU280 2.7 23.9 1.0 CE1 C:HIS56 2.7 33.5 1.0 OE1 C:GLU280 2.8 26.4 1.0 CD2 C:HIS56 2.9 29.6 1.0 ND1 C:HIS56 3.9 34.0 1.0 CG C:HIS56 4.0 32.6 1.0 CA C:GLY303 4.2 34.8 1.0 CG C:GLU280 4.2 24.4 1.0 O C:GLU280 4.4 29.9 1.0 N C:ALA304 4.5 34.2 1.0 C C:GLY303 4.9 35.2 1.0

Zinc binding site 2 out of 3 in the Influenza Virus Hemagglutinin, (Escape) Mutant with Thr 131 Replaced By Ile, Complexed with A Neutralizing Antibody


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Influenza Virus Hemagglutinin, (Escape) Mutant with Thr 131 Replaced By Ile, Complexed with A Neutralizing Antibody within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn211 b:49.5 occ:1.00 OD2 A:ASP154 1.8 9.1 1.0 ND1 A:HIS191 2.1 28.9 1.0 CG A:ASP154 2.8 14.4 1.0 CE1 A:HIS191 2.9 28.9 1.0 CG A:HIS191 3.3 25.6 1.0 CB A:ASP154 3.3 16.1 1.0 CB A:HIS191 3.8 26.6 1.0 OD1 A:ASP154 3.9 19.6 1.0 O A:ARG190 4.0 34.9 1.0 CA A:HIS191 4.0 29.2 1.0 NE2 A:HIS191 4.1 27.7 1.0 CD2 A:HIS191 4.3 25.9 1.0 CA A:ASP154 4.8 16.9 1.0 N A:SER192 4.9 32.6 1.0 C A:ARG190 4.9 34.9 1.0 CG1 A:VAL153 4.9 19.5 1.0 N A:HIS191 4.9 34.9 1.0

Zinc binding site 3 out of 3 in the Influenza Virus Hemagglutinin, (Escape) Mutant with Thr 131 Replaced By Ile, Complexed with A Neutralizing Antibody


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Influenza Virus Hemagglutinin, (Escape) Mutant with Thr 131 Replaced By Ile, Complexed with A Neutralizing Antibody within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn212 b:89.8 occ:1.00 NE2 B:HIS173 2.0 47.5 1.0 OD2 A:ASP141 2.4 37.7 1.0 CE1 B:HIS173 2.7 44.9 1.0 OD1 A:ASP141 2.9 31.0 1.0 CG A:ASP141 3.0 31.9 1.0 CD2 B:HIS173 3.3 42.5 1.0 ND1 B:HIS173 4.0 42.9 1.0 CG B:HIS173 4.3 39.0 1.0 NE2 A:GLN170 4.3 25.5 1.0 CB A:ASP141 4.4 25.2 1.0 CA B:GLY171 4.6 44.7 1.0 OG1 A:THR140 4.7 18.6 1.0 OE1 A:GLN170 4.9 20.4 1.0

D.Fleury, S.A.Wharton, J.J.Skehel, M.Knossow, T.Bizebard. Antigen Distortion Allows Influenza Virus to Escape Neutralization. Nat.Struct.Biol. V. 5 119 1998.
ISSN: ISSN 1072-8368
PubMed: 9461077
DOI: 10.1038/NSB0298-119