Zinc in PDB 2pw3: Structure of the PDE4D-Camp Complex

All present enzymatic activity of Structure of the PDE4D-Camp Complex:
3.1.4.17;

The structure of Structure of the PDE4D-Camp Complex, PDB code: 2pw3 was solved by H.Wang, H.Robinson, H.Ke, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 1.56
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	57.849, 81.000, 163.627, 90.00, 90.00, 90.00
R / Rfree (%)	21.2 / 23.1

The binding sites of Zinc atom in the Structure of the PDE4D-Camp Complex (pdb code 2pw3). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of the PDE4D-Camp Complex, PDB code: 2pw3:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of the PDE4D-Camp Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of the PDE4D-Camp Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn501 b:20.2 occ:1.00 OD1 A:ASP318 2.1 10.0 1.0 OD1 A:ASN201 2.1 11.3 1.0 NE2 A:HIS164 2.1 10.6 1.0 NE2 A:HIS200 2.1 9.4 1.0 O A:HOH502 2.2 14.0 1.0 O A:HOH503 2.2 12.4 1.0 CD2 A:HIS200 3.0 10.2 1.0 CG A:ASP318 3.0 13.2 1.0 CD2 A:HIS164 3.1 11.2 1.0 CG A:ASN201 3.1 12.6 1.0 CE1 A:HIS164 3.1 11.2 1.0 CE1 A:HIS200 3.1 11.1 1.0 OD2 A:ASP318 3.4 15.5 1.0 ND2 A:ASN201 3.7 15.5 1.0 O A:HOH504 4.1 13.2 1.0 CG A:HIS200 4.2 10.7 1.0 ND1 A:HIS164 4.2 10.9 1.0 ND1 A:HIS200 4.2 12.3 1.0 CG A:HIS164 4.2 9.7 1.0 O2P A:CMP1 4.3 21.9 1.0 CB A:ASN201 4.3 11.2 1.0 CD2 A:HIS160 4.4 14.1 1.0 CB A:ASP318 4.4 10.0 1.0 CG2 A:VAL168 4.6 11.8 1.0 NE2 A:HIS160 4.8 16.4 1.0 CA A:ASP318 4.9 10.0 1.0

Zinc binding site 2 out of 2 in the Structure of the PDE4D-Camp Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of the PDE4D-Camp Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn501 b:22.5 occ:1.00 OD1 B:ASP318 2.1 15.1 1.0 OD1 B:ASN201 2.1 12.2 1.0 NE2 B:HIS164 2.1 12.7 1.0 NE2 B:HIS200 2.1 12.7 1.0 O B:HOH503 2.2 15.1 1.0 O B:HOH502 2.3 15.5 1.0 CD2 B:HIS200 3.0 14.3 1.0 CG B:ASP318 3.1 16.0 1.0 CD2 B:HIS164 3.1 13.2 1.0 CG B:ASN201 3.1 12.7 1.0 CE1 B:HIS200 3.1 15.7 1.0 CE1 B:HIS164 3.1 15.0 1.0 OD2 B:ASP318 3.4 18.3 1.0 ND2 B:ASN201 3.6 15.4 1.0 O B:HOH504 4.2 14.7 1.0 CG B:HIS200 4.2 13.9 1.0 ND1 B:HIS200 4.2 15.1 1.0 ND1 B:HIS164 4.2 13.3 1.0 CG B:HIS164 4.2 14.3 1.0 O2P B:CMP1 4.3 23.1 1.0 CB B:ASN201 4.3 12.1 1.0 CB B:ASP318 4.4 15.5 1.0 CD2 B:HIS160 4.4 14.2 1.0 CG2 B:VAL168 4.6 17.0 1.0 NE2 B:HIS160 4.9 14.8 1.0 CA B:ASP318 4.9 15.2 1.0

H.Wang, H.Robinson, H.Ke. The Molecular Basis For Different Recognition of Substrates By Phosphodiesterase Families 4 and 10. J.Mol.Biol. V. 371 302 2007.
ISSN: ISSN 0022-2836
PubMed: 17582435
DOI: 10.1016/J.JMB.2007.05.060