Zinc in PDB 2nut: Crystal Structure of the Human SEC23A/24A Heterodimer, Complexed with the Snare Protein SEC22B

The structure of Crystal Structure of the Human SEC23A/24A Heterodimer, Complexed with the Snare Protein SEC22B, PDB code: 2nut was solved by J.D.Mancias, J.Goldberg, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 2.30
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	148.280, 97.580, 129.800, 90.00, 90.15, 90.00
R / Rfree (%)	21.9 / 26.8

The binding sites of Zinc atom in the Crystal Structure of the Human SEC23A/24A Heterodimer, Complexed with the Snare Protein SEC22B (pdb code 2nut). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of the Human SEC23A/24A Heterodimer, Complexed with the Snare Protein SEC22B, PDB code: 2nut:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of the Human SEC23A/24A Heterodimer, Complexed with the Snare Protein SEC22B


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Human SEC23A/24A Heterodimer, Complexed with the Snare Protein SEC22B within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn800 b:54.4 occ:1.00 SG A:CYS85 2.4 49.1 1.0 SG A:CYS88 2.5 57.0 1.0 SG A:CYS66 2.5 53.3 1.0 SG A:CYS61 2.6 54.0 1.0 CB A:CYS85 3.1 43.4 1.0 CB A:CYS66 3.2 57.4 1.0 CB A:CYS61 3.3 59.1 1.0 CB A:CYS88 3.8 55.5 1.0 N A:CYS88 4.0 56.5 1.0 CB A:GLN90 4.2 66.3 1.0 CA A:CYS88 4.4 57.9 1.0 N A:ARG67 4.6 60.4 1.0 CB A:ARG63 4.6 73.2 1.0 CA A:CYS85 4.6 48.6 1.0 CA A:CYS66 4.6 62.1 1.0 N A:ALA68 4.7 56.3 1.0 CB A:PHE87 4.7 56.4 1.0 N A:GLN90 4.8 69.0 1.0 CB A:ALA68 4.8 50.5 1.0 CA A:CYS61 4.8 61.6 1.0 C A:CYS88 4.9 57.0 1.0 C A:PHE87 4.9 53.6 1.0 C A:CYS66 4.9 58.4 1.0 CG A:GLN90 4.9 64.0 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of the Human SEC23A/24A Heterodimer, Complexed with the Snare Protein SEC22B


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the Human SEC23A/24A Heterodimer, Complexed with the Snare Protein SEC22B within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1100 b:34.9 occ:1.00 SG B:CYS452 2.4 39.4 1.0 SG B:CYS455 2.4 44.0 1.0 SG B:CYS431 2.5 42.2 1.0 SG B:CYS434 2.5 38.8 1.0 CB B:CYS431 3.1 38.8 1.0 CB B:CYS452 3.2 44.3 1.0 CB B:CYS455 3.2 32.1 1.0 CB B:CYS434 3.6 31.8 1.0 N B:CYS434 3.7 41.8 1.0 N B:CYS455 3.8 35.2 1.0 CA B:CYS455 4.0 38.8 1.0 CA B:CYS434 4.2 38.8 1.0 CB B:SER433 4.4 50.0 1.0 CB B:THR436 4.6 36.5 1.0 CA B:CYS431 4.6 45.7 1.0 C B:CYS455 4.6 40.5 1.0 OG1 B:THR436 4.6 44.4 1.0 CA B:CYS452 4.7 35.9 1.0 C B:LEU454 4.7 36.2 1.0 N B:TYR456 4.8 46.5 1.0 C B:CYS434 4.8 32.6 1.0 C B:SER433 4.8 43.8 1.0 CB B:ARG457 4.9 52.7 1.0 N B:ARG457 4.9 47.7 1.0 N B:SER433 4.9 43.5 1.0 CA B:SER433 5.0 46.4 1.0 N B:THR436 5.0 34.2 1.0 CB B:LEU454 5.0 24.6 1.0

J.D.Mancias, J.Goldberg. The Transport Signal on SEC22 For Packaging Into Copii-Coated Vesicles Is A Conformational Epitope Mol.Cell V. 26 403 2007.
ISSN: ISSN 1097-2765
PubMed: 17499046
DOI: 10.1016/J.MOLCEL.2007.03.017