Zinc in PDB 2h1l: The Structure of the Oncoprotein SV40 Large T Antigen and P53 Tumor Suppressor Complex

The structure of The Structure of the Oncoprotein SV40 Large T Antigen and P53 Tumor Suppressor Complex, PDB code: 2h1l was solved by W.Lilyestrom, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 3.16
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	127.019, 182.718, 262.061, 90.00, 92.08, 90.00
R / Rfree (%)	26.1 / 30.8

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 24;

Binding sites:

The binding sites of Zinc atom in the The Structure of the Oncoprotein SV40 Large T Antigen and P53 Tumor Suppressor Complex (pdb code 2h1l). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 24 binding sites of Zinc where determined in the The Structure of the Oncoprotein SV40 Large T Antigen and P53 Tumor Suppressor Complex, PDB code: 2h1l:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Zinc binding site 1 out of 24 in the The Structure of the Oncoprotein SV40 Large T Antigen and P53 Tumor Suppressor Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of The Structure of the Oncoprotein SV40 Large T Antigen and P53 Tumor Suppressor Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1 b:66.1 occ:1.00 SG A:CYS305 2.2 94.5 1.0 SG A:CYS302 2.3 95.0 1.0 NE2 A:HIS313 2.6 71.6 1.0 ND1 A:HIS317 2.6 65.8 1.0 CG A:HIS317 2.8 65.2 1.0 CE1 A:HIS313 2.9 71.8 1.0 CB A:CYS302 3.1 98.8 1.0 CB A:HIS317 3.2 66.0 1.0 CE1 A:HIS317 3.2 65.2 1.0 CD2 A:HIS317 3.5 64.8 1.0 CD2 A:HIS313 3.6 71.6 1.0 NE2 A:HIS317 3.7 65.1 1.0 ND1 A:HIS313 3.9 71.0 1.0 CB A:CYS305 4.0 92.7 1.0 CG A:HIS313 4.2 70.0 1.0 CA A:PHE299 4.6 0.5 1.0 CA A:CYS302 4.6 0.6 1.0 CB A:PHE299 4.6 1.0 1.0 O A:HIS313 4.7 65.2 1.0 CA A:HIS317 4.7 68.9 1.0 N A:CYS305 4.8 91.8 1.0 CA A:CYS305 4.9 91.5 1.0 O A:SER298 4.9 0.4 1.0

Zinc binding site 2 out of 24 in the The Structure of the Oncoprotein SV40 Large T Antigen and P53 Tumor Suppressor Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of The Structure of the Oncoprotein SV40 Large T Antigen and P53 Tumor Suppressor Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn2 b:71.8 occ:1.00 ND1 B:HIS317 2.1 63.7 1.0 SG B:CYS302 2.1 0.8 1.0 SG B:CYS305 2.5 95.7 1.0 NE2 B:HIS313 2.6 65.7 1.0 CB B:CYS302 2.8 0.8 1.0 CE1 B:HIS317 2.8 62.4 1.0 CG B:HIS317 3.2 65.5 1.0 CD2 B:HIS313 3.4 65.7 1.0 CE1 B:HIS313 3.5 66.5 1.0 CB B:HIS317 3.6 68.4 1.0 NE2 B:HIS317 4.0 63.6 1.0 CA B:CYS302 4.1 0.6 1.0 CD2 B:HIS317 4.1 65.5 1.0 CB B:CYS305 4.3 96.7 1.0 CG B:HIS313 4.6 66.5 1.0 ND1 B:HIS313 4.6 67.2 1.0 O B:SER298 4.6 0.9 1.0 CA B:PHE299 4.7 0.3 1.0 N B:CYS305 4.8 96.0 1.0 C B:CYS302 4.9 0.0 1.0 CB B:PHE299 5.0 0.4 1.0

Zinc binding site 3 out of 24 in the The Structure of the Oncoprotein SV40 Large T Antigen and P53 Tumor Suppressor Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of The Structure of the Oncoprotein SV40 Large T Antigen and P53 Tumor Suppressor Complex within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn3 b:84.1 occ:1.00 SG D:CYS305 1.8 98.7 1.0 ND1 D:HIS317 1.9 63.3 1.0 CB D:CYS305 2.5 0.1 1.0 CG D:HIS317 2.8 62.1 1.0 CE1 D:HIS317 2.9 62.2 1.0 CB D:HIS317 3.2 62.7 1.0 SG D:CYS302 3.6 0.6 1.0 NE2 D:HIS313 3.7 69.0 1.0 CE1 D:HIS313 3.7 68.7 1.0 CA D:CYS305 3.9 99.6 1.0 NE2 D:HIS317 3.9 62.9 1.0 CD2 D:HIS317 3.9 62.8 1.0 CB D:CYS302 3.9 1.0 1.0 CB D:PHE299 4.2 0.3 1.0 CA D:PHE299 4.3 0.8 1.0 ND1 D:HIS313 4.4 70.3 1.0 CD2 D:HIS313 4.4 70.3 1.0 N D:CYS305 4.6 0.4 1.0 CA D:HIS317 4.7 65.7 1.0 C D:CYS305 4.9 98.5 1.0 CG D:HIS313 4.9 70.7 1.0 CA D:TYR314 4.9 68.7 1.0 O D:PHE299 4.9 0.6 1.0

Zinc binding site 4 out of 24 in the The Structure of the Oncoprotein SV40 Large T Antigen and P53 Tumor Suppressor Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of The Structure of the Oncoprotein SV40 Large T Antigen and P53 Tumor Suppressor Complex within 5.0Å range: probe atom residue distance (Å) B Occ E:Zn4 b:57.9 occ:1.00 SG E:CYS305 2.1 0.4 1.0 SG E:CYS302 2.4 0.8 1.0 CD2 E:HIS317 2.5 79.6 1.0 NE2 E:HIS313 2.7 74.6 1.0 NE2 E:HIS317 2.9 75.9 1.0 CG E:HIS317 3.2 79.4 1.0 CE1 E:HIS313 3.4 74.5 1.0 CD2 E:HIS313 3.6 73.7 1.0 CB E:CYS302 3.7 0.0 1.0 CE1 E:HIS317 3.7 76.3 1.0 CB E:CYS305 3.9 98.9 1.0 ND1 E:HIS317 3.9 78.8 1.0 CB E:HIS317 4.0 80.7 1.0 N E:CYS305 4.2 97.3 1.0 CA E:CYS305 4.4 95.9 1.0 ND1 E:HIS313 4.5 75.8 1.0 CG E:HIS313 4.6 74.1 1.0 CB E:LYS304 4.8 96.7 1.0 CA E:PHE299 4.9 0.9 1.0 O E:HIS313 4.9 69.4 1.0

Zinc binding site 5 out of 24 in the The Structure of the Oncoprotein SV40 Large T Antigen and P53 Tumor Suppressor Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of The Structure of the Oncoprotein SV40 Large T Antigen and P53 Tumor Suppressor Complex within 5.0Å range: probe atom residue distance (Å) B Occ F:Zn5 b:68.8 occ:1.00 ND1 F:HIS317 2.2 64.5 1.0 SG F:CYS302 2.4 96.4 1.0 SG F:CYS305 2.4 94.7 1.0 NE2 F:HIS313 2.8 81.1 1.0 CG F:HIS317 2.9 65.4 1.0 CB F:CYS302 2.9 98.4 1.0 CE1 F:HIS313 3.1 80.0 1.0 CB F:HIS317 3.1 65.5 1.0 CE1 F:HIS317 3.2 63.8 1.0 CD2 F:HIS313 3.8 82.2 1.0 CD2 F:HIS317 4.0 65.7 1.0 ND1 F:HIS313 4.1 81.7 1.0 NE2 F:HIS317 4.2 64.5 1.0 CB F:CYS305 4.2 94.3 1.0 CD1 F:PHE299 4.4 0.0 1.0 CA F:CYS302 4.4 0.2 1.0 CG F:HIS313 4.5 81.8 1.0 CA F:HIS317 4.6 67.5 1.0 N F:CYS305 4.9 94.0 1.0 CE1 F:PHE299 4.9 0.1 1.0 CA F:PHE299 5.0 0.7 1.0 O F:PHE299 5.0 0.7 1.0

Zinc binding site 6 out of 24 in the The Structure of the Oncoprotein SV40 Large T Antigen and P53 Tumor Suppressor Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of The Structure of the Oncoprotein SV40 Large T Antigen and P53 Tumor Suppressor Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn6 b:79.2 occ:1.00 ND1 C:HIS317 2.0 62.7 1.0 SG C:CYS305 2.4 99.8 1.0 SG C:CYS302 2.5 0.4 1.0 CB C:CYS302 2.6 0.9 1.0 CE1 C:HIS317 2.9 59.8 1.0 CG C:HIS317 2.9 64.9 1.0 NE2 C:HIS313 2.9 74.4 1.0 CE1 C:HIS313 3.2 74.2 1.0 CB C:HIS317 3.4 69.1 1.0 NE2 C:HIS317 3.8 61.3 1.0 CD2 C:HIS317 3.9 63.5 1.0 CD2 C:HIS313 4.0 74.8 1.0 CB C:CYS305 4.1 0.5 1.0 CA C:CYS302 4.1 0.3 1.0 ND1 C:HIS313 4.3 73.8 1.0 CD1 C:PHE299 4.4 0.1 1.0 O C:PHE299 4.6 0.7 1.0 O C:SER298 4.6 0.3 1.0 CA C:PHE299 4.6 0.5 1.0 CG C:HIS313 4.7 74.7 1.0 N C:CYS302 4.9 0.9 1.0 CA C:HIS317 4.9 72.7 1.0

Zinc binding site 7 out of 24 in the The Structure of the Oncoprotein SV40 Large T Antigen and P53 Tumor Suppressor Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of The Structure of the Oncoprotein SV40 Large T Antigen and P53 Tumor Suppressor Complex within 5.0Å range: probe atom residue distance (Å) B Occ G:Zn7 b:66.1 occ:1.00 SG G:CYS302 2.0 75.6 1.0 SG G:CYS305 2.2 71.6 1.0 NE2 G:HIS313 2.2 40.1 1.0 ND1 G:HIS317 2.2 53.5 1.0 CE1 G:HIS313 2.8 41.5 1.0 CG G:HIS317 3.0 54.6 1.0 CE1 G:HIS317 3.2 52.6 1.0 CD2 G:HIS313 3.2 42.9 1.0 CB G:HIS317 3.3 55.5 1.0 CB G:CYS302 3.4 80.6 1.0 ND1 G:HIS313 3.9 42.7 1.0 CB G:CYS305 3.9 73.5 1.0 CD2 G:HIS317 4.0 54.8 1.0 CG G:HIS313 4.1 44.7 1.0 NE2 G:HIS317 4.1 52.6 1.0 N G:CYS305 4.3 72.4 1.0 CB G:LYS304 4.5 68.0 1.0 CA G:CYS305 4.6 74.7 1.0 O G:HIS313 4.7 47.7 1.0 CA G:CYS302 4.7 83.9 1.0 CA G:HIS317 4.8 57.0 1.0 C G:LYS304 4.8 71.1 1.0 CA G:PHE299 4.9 90.8 1.0 CD1 G:PHE295 4.9 56.2 1.0 CB G:PHE299 5.0 90.6 1.0

Zinc binding site 8 out of 24 in the The Structure of the Oncoprotein SV40 Large T Antigen and P53 Tumor Suppressor Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 8 of The Structure of the Oncoprotein SV40 Large T Antigen and P53 Tumor Suppressor Complex within 5.0Å range: probe atom residue distance (Å) B Occ I:Zn8 b:60.2 occ:1.00 SG I:CYS302 2.1 95.0 1.0 SG I:CYS305 2.1 91.6 1.0 ND1 I:HIS317 2.1 51.2 1.0 NE2 I:HIS313 2.6 56.4 1.0 CB I:CYS302 3.1 97.6 1.0 CE1 I:HIS317 3.1 49.1 1.0 CG I:HIS317 3.1 50.2 1.0 CD2 I:HIS313 3.4 56.8 1.0 CB I:HIS317 3.4 51.0 1.0 CE1 I:HIS313 3.5 56.3 1.0 CB I:CYS305 4.0 91.3 1.0 NE2 I:HIS317 4.1 48.9 1.0 CD2 I:HIS317 4.1 50.5 1.0 CG I:HIS313 4.4 57.7 1.0 ND1 I:HIS313 4.4 58.0 1.0 CD1 I:PHE299 4.5 99.9 1.0 CA I:CYS302 4.5 99.3 1.0 N I:CYS305 4.6 90.6 1.0 CA I:CYS305 4.8 91.3 1.0 CA I:HIS317 4.9 52.6 1.0 CB I:LYS304 5.0 88.5 1.0 CE1 I:PHE299 5.0 0.5 1.0 O I:PHE299 5.0 99.9 1.0

Zinc binding site 9 out of 24 in the The Structure of the Oncoprotein SV40 Large T Antigen and P53 Tumor Suppressor Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 9 of The Structure of the Oncoprotein SV40 Large T Antigen and P53 Tumor Suppressor Complex within 5.0Å range: probe atom residue distance (Å) B Occ H:Zn9 b:60.7 occ:1.00 ND1 H:HIS317 2.1 50.1 1.0 SG H:CYS305 2.1 95.8 1.0 SG H:CYS302 2.2 94.3 1.0 NE2 H:HIS313 2.3 49.2 1.0 CG H:HIS317 3.0 51.8 1.0 CE1 H:HIS313 3.0 50.2 1.0 CE1 H:HIS317 3.1 47.8 1.0 CB H:HIS317 3.2 55.0 1.0 CD2 H:HIS313 3.3 50.1 1.0 CB H:CYS302 3.5 94.5 1.0 CB H:CYS305 3.9 93.4 1.0 ND1 H:HIS313 4.1 52.0 1.0 CD2 H:HIS317 4.1 50.9 1.0 NE2 H:HIS317 4.1 48.5 1.0 CG H:HIS313 4.2 52.1 1.0 N H:CYS305 4.5 92.1 1.0 C H:LYS304 4.5 91.3 1.0 CB H:PHE299 4.6 95.3 1.0 CB H:LYS304 4.6 90.0 1.0 CA H:CYS305 4.6 93.2 1.0 CA H:HIS317 4.7 58.8 1.0 O H:LYS304 4.7 90.8 1.0 CA H:TYR314 4.8 62.6 1.0 CA H:CYS302 4.9 94.9 1.0

Zinc binding site 10 out of 24 in the The Structure of the Oncoprotein SV40 Large T Antigen and P53 Tumor Suppressor Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 10 of The Structure of the Oncoprotein SV40 Large T Antigen and P53 Tumor Suppressor Complex within 5.0Å range: probe atom residue distance (Å) B Occ J:Zn10 b:76.9 occ:1.00 ND1 J:HIS317 2.0 58.2 1.0 SG J:CYS305 2.0 0.9 1.0 SG J:CYS302 2.4 0.3 1.0 CE1 J:HIS317 2.9 58.1 1.0 CG J:HIS317 2.9 61.4 1.0 NE2 J:HIS313 3.0 67.5 1.0 CE1 J:HIS313 3.0 65.4 1.0 CB J:HIS317 3.3 63.0 1.0 CB J:CYS305 3.7 0.3 1.0 CB J:CYS302 3.8 0.0 1.0 CD2 J:HIS313 3.8 66.2 1.0 ND1 J:HIS313 3.9 65.5 1.0 N J:CYS305 4.0 0.8 1.0 NE2 J:HIS317 4.0 58.8 1.0 CD2 J:HIS317 4.0 60.7 1.0 CA J:CYS305 4.1 0.8 1.0 CG J:HIS313 4.3 67.0 1.0 CA J:TYR314 4.7 68.0 1.0 CB J:LYS304 4.8 0.9 1.0 C J:LYS304 4.8 0.2 1.0 CA J:HIS317 4.8 64.9 1.0 O J:HIS313 4.9 71.0 1.0

W.Lilyestrom, M.G.Klein, R.Zhang, A.Joachimiak, X.S.Chen. Crystal Structure of SV40 Large T-Antigen Bound to P53: Interplay Between A Viral Oncoprotein and A Cellular Tumor Suppressor. Genes Dev. V. 20 2373 2006.
ISSN: ISSN 0890-9369
PubMed: 16951253
DOI: 10.1101/GAD.1456306