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Zinc in PDB 1zlh: Crystal Structure of the Tick Carboxypeptidase Inhibitor in Complex with Bovine Carboxypeptidase A

Enzymatic activity of Crystal Structure of the Tick Carboxypeptidase Inhibitor in Complex with Bovine Carboxypeptidase A

All present enzymatic activity of Crystal Structure of the Tick Carboxypeptidase Inhibitor in Complex with Bovine Carboxypeptidase A:
3.4.17.1;

Protein crystallography data

The structure of Crystal Structure of the Tick Carboxypeptidase Inhibitor in Complex with Bovine Carboxypeptidase A, PDB code: 1zlh was solved by J.L.Arolas, G.M.Popowicz, J.Lorenzo, C.P.Sommerhoff, R.Huber, F.X.Aviles, T.A.Holak, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 55.90 / 1.70
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 47.070, 68.600, 57.890, 90.00, 104.72, 90.00
R / Rfree (%) 15.4 / 18.5

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of the Tick Carboxypeptidase Inhibitor in Complex with Bovine Carboxypeptidase A (pdb code 1zlh). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 5 binding sites of Zinc where determined in the Crystal Structure of the Tick Carboxypeptidase Inhibitor in Complex with Bovine Carboxypeptidase A, PDB code: 1zlh:
Jump to Zinc binding site number: 1; 2; 3; 4; 5;

Zinc binding site 1 out of 5 in 1zlh

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Zinc binding site 1 out of 5 in the Crystal Structure of the Tick Carboxypeptidase Inhibitor in Complex with Bovine Carboxypeptidase A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Tick Carboxypeptidase Inhibitor in Complex with Bovine Carboxypeptidase A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn555

b:10.8
occ:1.00
OE2 A:GLU72 2.0 11.5 1.0
ND1 A:HIS196 2.1 8.3 1.0
ND1 A:HIS69 2.1 7.8 1.0
O B:LEU74 2.1 10.9 1.0
C B:LEU74 2.6 10.8 1.0
CD A:GLU72 2.8 10.2 1.0
OE1 A:GLU72 2.8 10.2 1.0
CE1 A:HIS196 3.0 8.5 1.0
CE1 A:HIS69 3.0 7.5 1.0
CG A:HIS69 3.1 8.6 1.0
CG A:HIS196 3.1 9.0 1.0
CB A:HIS69 3.5 9.2 1.0
CB A:HIS196 3.5 9.2 1.0
O A:HOH1017 3.9 9.1 1.0
CA B:LEU74 4.0 10.8 1.0
NH2 A:ARG127 4.1 11.4 1.0
NE2 A:HIS196 4.1 8.8 1.0
NE2 A:HIS69 4.1 7.6 1.0
CD2 A:HIS196 4.2 8.4 1.0
CD2 A:HIS69 4.2 8.5 1.0
O A:SER197 4.2 10.6 1.0
CG A:GLU72 4.2 9.4 1.0
O A:HOH1288 4.3 9.7 1.0
O A:HOH1036 4.4 9.6 1.0
CA A:HIS196 4.5 9.4 1.0
O A:HOH1289 4.5 17.3 1.0
N A:SER197 4.8 10.2 1.0
OE2 A:GLU270 4.8 12.0 1.0
N B:LEU74 4.8 10.7 1.0
CA A:HIS69 4.9 8.9 1.0
O A:HOH1021 4.9 9.7 1.0
CZ A:ARG127 4.9 11.3 1.0
OE1 A:GLU270 5.0 10.2 1.0
CB B:LEU74 5.0 10.8 1.0

Zinc binding site 2 out of 5 in 1zlh

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Zinc binding site 2 out of 5 in the Crystal Structure of the Tick Carboxypeptidase Inhibitor in Complex with Bovine Carboxypeptidase A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the Tick Carboxypeptidase Inhibitor in Complex with Bovine Carboxypeptidase A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn666

b:11.6
occ:1.00
O B:HOH155 2.0 18.2 1.0
N B:ASN1 2.0 10.7 1.0
NE2 A:HIS120 2.1 9.3 1.0
O B:HOH79 2.9 15.4 1.0
CD2 A:HIS120 3.0 9.7 1.0
CA B:ASN1 3.1 11.1 1.0
CE1 A:HIS120 3.1 9.7 1.0
CB B:ASN1 3.3 11.0 1.0
CG B:ASN1 3.6 11.4 1.0
ND2 B:ASN1 3.7 11.5 1.0
CG2 A:THR14 4.1 12.9 1.0
CG A:HIS120 4.2 9.9 1.0
ND1 A:HIS120 4.2 10.0 1.0
O B:HOH112 4.3 17.3 1.0
OD1 B:ASN1 4.3 11.2 1.0
O B:HOH117 4.4 18.9 1.0
C B:ASN1 4.4 11.0 1.0
O B:ASN1 4.7 10.8 1.0

Zinc binding site 3 out of 5 in 1zlh

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Zinc binding site 3 out of 5 in the Crystal Structure of the Tick Carboxypeptidase Inhibitor in Complex with Bovine Carboxypeptidase A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of the Tick Carboxypeptidase Inhibitor in Complex with Bovine Carboxypeptidase A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn777

b:20.3
occ:1.00
OD1 A:ASP16 2.0 13.3 1.0
O A:HOH1216 2.2 8.0 1.0
CG A:ASP16 2.9 13.5 1.0
O A:HOH1117 2.9 16.0 1.0
OD2 A:ASP16 3.0 14.7 1.0
O A:HOH1054 4.1 12.3 1.0
CB A:ASP16 4.3 12.5 1.0
CD2 A:LEU15 4.3 16.0 1.0
CD1 A:LEU15 4.5 12.9 1.0
NE A:ARG45 4.6 12.3 1.0
CA A:ASP16 4.7 12.5 1.0
N A:ASP16 4.7 12.4 1.0
CG A:LEU15 4.8 13.6 1.0
CB A:LEU15 4.9 12.8 1.0

Zinc binding site 4 out of 5 in 1zlh

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Zinc binding site 4 out of 5 in the Crystal Structure of the Tick Carboxypeptidase Inhibitor in Complex with Bovine Carboxypeptidase A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of the Tick Carboxypeptidase Inhibitor in Complex with Bovine Carboxypeptidase A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn888

b:26.9
occ:1.00
NE2 A:HIS29 2.1 18.9 1.0
O A:HOH1246 2.1 26.6 1.0
O A:HOH1197 2.1 21.2 1.0
O A:HOH1272 2.1 17.7 1.0
O A:HOH1168 2.2 26.5 1.0
O A:HOH1277 2.4 26.7 1.0
CE1 A:HIS29 3.0 19.2 1.0
CD2 A:HIS29 3.1 18.6 1.0
OE2 A:GLU88 3.8 24.3 1.0
NZ A:LYS84 4.0 19.5 1.0
ND1 A:HIS29 4.1 18.9 1.0
CG A:HIS29 4.2 18.1 1.0
OG1 A:THR87 4.3 17.1 1.0
O A:THR87 4.5 18.4 1.0
CB A:THR87 4.6 17.2 1.0
CD A:GLU88 4.9 23.5 1.0
C A:THR87 5.0 17.9 1.0

Zinc binding site 5 out of 5 in 1zlh

Go back to Zinc Binding Sites List in 1zlh
Zinc binding site 5 out of 5 in the Crystal Structure of the Tick Carboxypeptidase Inhibitor in Complex with Bovine Carboxypeptidase A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Crystal Structure of the Tick Carboxypeptidase Inhibitor in Complex with Bovine Carboxypeptidase A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn999

b:46.1
occ:1.00
ND1 A:HIS303 2.1 24.4 1.0
O A:HOH1257 2.3 25.0 1.0
O A:HOH1271 2.7 27.9 1.0
CG A:HIS303 3.0 23.6 1.0
CE1 A:HIS303 3.1 24.5 1.0
CB A:HIS303 3.2 22.5 1.0
CA A:HIS303 4.0 22.4 1.0
CD2 A:HIS303 4.1 24.1 1.0
NE2 A:HIS303 4.2 24.4 1.0
CG2 A:VAL222 4.6 14.2 1.0
N A:HIS303 4.7 21.1 1.0

Reference:

J.L.Arolas, G.M.Popowicz, J.Lorenzo, C.P.Sommerhoff, R.Huber, F.X.Aviles, T.A.Holak. The Three-Dimensional Structures of Tick Carboxypeptidase Inhibitor in Complex with A/B Carboxypeptidases Reveal A Novel Double-Headed Binding Mode J.Mol.Biol. V. 350 489 2005.
ISSN: ISSN 0022-2836
PubMed: 15961103
DOI: 10.1016/J.JMB.2005.05.015
Page generated: Wed Dec 16 03:15:49 2020

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