Zinc in PDB 1zh1: Structure of the Zinc-Binding Domain of Hcv NS5A

The structure of Structure of the Zinc-Binding Domain of Hcv NS5A, PDB code: 1zh1 was solved by T.L.Tellinghuisen, J.Marcotrigiano, C.M.Rice, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 2.50
Space group	P 41 2 2
Cell size a, b, c (Å), α, β, γ (°)	55.280, 55.280, 312.300, 90.00, 90.00, 90.00
R / Rfree (%)	22.7 / 28.6

The binding sites of Zinc atom in the Structure of the Zinc-Binding Domain of Hcv NS5A (pdb code 1zh1). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of the Zinc-Binding Domain of Hcv NS5A, PDB code: 1zh1:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of the Zinc-Binding Domain of Hcv NS5A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of the Zinc-Binding Domain of Hcv NS5A within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn199 b:29.1 occ:1.00 SG A:CYS39 2.4 21.0 1.0 SG A:CYS59 2.4 20.6 1.0 SG A:CYS80 2.5 23.2 1.0 SG A:CYS57 2.5 18.5 1.0 CB A:CYS39 3.2 18.8 1.0 CB A:CYS80 3.2 22.3 1.0 CB A:CYS57 3.2 19.6 1.0 CB A:CYS59 3.4 18.7 1.0 CA A:CYS80 3.7 22.4 1.0 CA A:CYS39 3.8 20.8 1.0 N A:SER81 3.9 20.9 1.0 ND2 A:ASN82 4.2 25.1 1.0 N A:CYS59 4.2 18.2 1.0 C A:CYS80 4.3 20.9 1.0 CA A:CYS59 4.4 19.1 1.0 CB A:ALA61 4.5 26.8 1.0 CA A:CYS57 4.6 19.5 1.0 N A:CYS39 4.7 21.8 1.0 N A:ASN82 4.8 22.2 1.0 C A:CYS57 4.9 19.2 1.0 C A:CYS39 4.9 20.8 1.0 N A:GLN40 4.9 20.4 1.0 N A:CYS80 4.9 23.8 1.0 CA A:SER81 5.0 21.4 1.0

Zinc binding site 2 out of 2 in the Structure of the Zinc-Binding Domain of Hcv NS5A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of the Zinc-Binding Domain of Hcv NS5A within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn199 b:25.9 occ:1.00 SG B:CYS57 2.4 19.5 1.0 SG B:CYS80 2.4 15.9 1.0 SG B:CYS59 2.5 23.3 1.0 SG B:CYS39 2.5 21.6 1.0 CB B:CYS57 3.1 16.6 1.0 CB B:CYS39 3.2 17.8 1.0 CB B:CYS59 3.2 22.6 1.0 CB B:CYS80 3.4 19.8 1.0 CA B:CYS39 3.7 18.3 1.0 CA B:CYS80 3.8 21.0 1.0 N B:SER81 4.0 22.1 1.0 ND2 B:ASN82 4.1 13.3 1.0 N B:CYS59 4.3 22.4 1.0 C B:CYS80 4.3 21.9 1.0 CA B:CYS59 4.4 22.8 1.0 CA B:CYS57 4.5 19.3 1.0 CB B:ALA61 4.6 20.8 1.0 N B:CYS39 4.6 19.1 1.0 C B:CYS39 4.7 20.0 1.0 N B:GLN40 4.7 19.2 1.0 N B:ASN82 4.8 17.4 1.0 C B:CYS57 4.8 21.2 1.0

T.L.Tellinghuisen, J.Marcotrigiano, C.M.Rice. Structure of the Zinc-Binding Domain of An Essential Component of the Hepatitis C Virus Replicase. Nature V. 435 374 2005.
ISSN: ISSN 0028-0836
PubMed: 15902263
DOI: 10.1038/NATURE03580