Zinc in PDB 1xcr: Crystal Structure of Longer Splice Variant of PTD012 From Homo Sapiens Reveals A Novel Zinc-Containing Fold

The structure of Crystal Structure of Longer Splice Variant of PTD012 From Homo Sapiens Reveals A Novel Zinc-Containing Fold, PDB code: 1xcr was solved by B.A.Manjasetty, M.Fieber-Erdmann, Y.Roske, F.Goetz, K.Buessow, U.Heinemann, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 1.70
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	44.572, 52.888, 124.485, 90.00, 88.89, 90.00
R / Rfree (%)	19 / 22.2

The binding sites of Zinc atom in the Crystal Structure of Longer Splice Variant of PTD012 From Homo Sapiens Reveals A Novel Zinc-Containing Fold (pdb code 1xcr). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Longer Splice Variant of PTD012 From Homo Sapiens Reveals A Novel Zinc-Containing Fold, PDB code: 1xcr:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Longer Splice Variant of PTD012 From Homo Sapiens Reveals A Novel Zinc-Containing Fold


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Longer Splice Variant of PTD012 From Homo Sapiens Reveals A Novel Zinc-Containing Fold within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:25.4 occ:1.00 NE2 A:HIS266 2.0 23.3 1.0 OXT A:ACY2001 2.1 27.3 1.0 NE2 A:HIS268 2.1 24.4 1.0 ND1 A:HIS278 2.2 23.5 1.0 CD2 A:HIS268 3.0 23.1 1.0 C A:ACY2001 3.0 26.6 0.5 CD2 A:HIS266 3.0 23.4 1.0 CE1 A:HIS266 3.0 24.4 1.0 CE1 A:HIS278 3.1 25.9 1.0 CH3 A:ACY2001 3.1 25.7 0.5 CE1 A:HIS268 3.1 23.3 1.0 CG A:HIS278 3.2 24.5 1.0 CB A:HIS278 3.6 23.8 1.0 OE1 A:GLU110 3.7 30.3 1.0 O A:HOH2126 4.0 40.3 1.0 O A:HOH2062 4.1 31.7 1.0 ND1 A:HIS266 4.1 24.1 1.0 CG A:HIS268 4.1 21.7 1.0 CG A:HIS266 4.2 24.2 1.0 O A:ACY2001 4.2 26.3 0.5 ND1 A:HIS268 4.2 22.7 1.0 NE2 A:HIS278 4.2 23.4 1.0 CD2 A:HIS278 4.3 23.5 1.0 CA A:HIS278 4.5 24.3 1.0 NE2 A:HIS217 4.6 26.3 1.0 NH2 A:ARG263 4.6 33.5 1.0 CD A:GLU110 4.7 27.5 1.0 CE1 A:HIS217 4.8 26.8 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Longer Splice Variant of PTD012 From Homo Sapiens Reveals A Novel Zinc-Containing Fold


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Longer Splice Variant of PTD012 From Homo Sapiens Reveals A Novel Zinc-Containing Fold within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1002 b:17.1 occ:1.00 OXT B:ACY2002 2.0 20.3 1.0 NE2 B:HIS268 2.0 20.4 1.0 NE2 B:HIS266 2.0 20.1 1.0 ND1 B:HIS278 2.1 21.9 1.0 C B:ACY2002 2.9 19.0 0.5 CD2 B:HIS268 3.0 21.3 1.0 CE1 B:HIS278 3.0 23.8 1.0 CE1 B:HIS266 3.0 22.6 1.0 CE1 B:HIS268 3.0 20.7 1.0 CH3 B:ACY2002 3.0 17.4 0.5 CD2 B:HIS266 3.0 20.2 1.0 CG B:HIS278 3.2 21.1 1.0 CB B:HIS278 3.6 21.1 1.0 OE1 B:GLU110 3.8 29.5 1.0 O B:HOH2054 4.1 29.9 1.0 O B:ACY2002 4.1 18.1 0.5 ND1 B:HIS268 4.1 19.5 1.0 CG B:HIS268 4.1 20.9 1.0 ND1 B:HIS266 4.1 21.2 1.0 O B:HOH2140 4.1 27.7 1.0 NE2 B:HIS278 4.2 22.6 1.0 CG B:HIS266 4.2 20.7 1.0 CD2 B:HIS278 4.3 21.2 1.0 CA B:HIS278 4.6 20.6 1.0 NH2 B:ARG263 4.6 30.3 1.0 NE2 B:HIS217 4.7 22.4 1.0 CD B:GLU110 4.7 25.6 1.0 CB B:ALA97 4.9 22.2 1.0

B.A.Manjasetty, K.Buessow, M.Fieber-Erdmann, Y.Roske, J.Gobom, C.Scheich, F.Goetz, F.H.Niesen, U.Heinemann. Crystal Structure of Homo Sapiens PTD012 Reveals A Zinc-Containing Hydrolase Fold Protein Sci. V. 15 914 2006.
ISSN: ISSN 0961-8368
PubMed: 16522806
DOI: 10.1110/PS.052037006