Zinc in PDB 1kzy: Crystal Structure of the 53BP1 Brct Region Complexed to Tumor Suppressor P53

The structure of Crystal Structure of the 53BP1 Brct Region Complexed to Tumor Suppressor P53, PDB code: 1kzy was solved by W.S.Joo, P.D.Jeffrey, S.B.Cantor, M.S.Finnin, D.M.Livingston, N.P.Pavletich, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	15.00 / 2.50
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	73.132, 94.976, 133.680, 90.00, 90.00, 90.00
R / Rfree (%)	21.6 / 25.6

The binding sites of Zinc atom in the Crystal Structure of the 53BP1 Brct Region Complexed to Tumor Suppressor P53 (pdb code 1kzy). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of the 53BP1 Brct Region Complexed to Tumor Suppressor P53, PDB code: 1kzy:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of the 53BP1 Brct Region Complexed to Tumor Suppressor P53


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the 53BP1 Brct Region Complexed to Tumor Suppressor P53 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1 b:41.1 occ:1.00 SG A:CYS176 2.2 36.4 1.0 ND1 A:HIS179 2.2 39.3 1.0 SG A:CYS242 2.4 34.4 1.0 SG A:CYS238 2.5 38.1 1.0 CB A:CYS242 3.1 34.0 1.0 CE1 A:HIS179 3.1 38.0 1.0 CG A:HIS179 3.3 40.9 1.0 CB A:CYS176 3.4 32.3 1.0 CB A:CYS238 3.4 33.5 1.0 CB A:HIS179 3.7 45.1 1.0 N A:CYS176 3.9 31.3 1.0 CA A:CYS238 4.0 29.3 1.0 O A:HOH339 4.1 46.2 1.0 CA A:CYS176 4.2 29.2 1.0 NE2 A:HIS179 4.3 42.5 1.0 CD2 A:HIS179 4.4 42.5 1.0 N A:HIS179 4.5 43.7 1.0 CA A:CYS242 4.5 31.8 1.0 N A:ASN239 4.6 28.0 1.0 O A:MET237 4.6 33.1 1.0 O A:CYS176 4.7 27.5 1.0 CA A:HIS179 4.7 46.7 1.0 C A:CYS176 4.8 30.7 1.0 C A:CYS238 4.8 29.6 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of the 53BP1 Brct Region Complexed to Tumor Suppressor P53


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the 53BP1 Brct Region Complexed to Tumor Suppressor P53 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1 b:50.5 occ:1.00 ND1 B:HIS179 2.1 38.6 1.0 SG B:CYS176 2.3 37.1 1.0 SG B:CYS238 2.3 39.9 1.0 SG B:CYS242 2.5 37.1 1.0 CE1 B:HIS179 3.1 40.0 1.0 CG B:HIS179 3.1 44.9 1.0 CB B:CYS242 3.2 30.9 1.0 CB B:CYS238 3.3 36.4 1.0 CB B:CYS176 3.4 39.9 1.0 CB B:HIS179 3.5 46.9 1.0 CA B:CYS238 3.9 32.5 1.0 N B:CYS176 4.0 35.9 1.0 NE2 B:HIS179 4.3 44.5 1.0 CD2 B:HIS179 4.3 45.2 1.0 CA B:CYS176 4.3 34.3 1.0 N B:HIS179 4.4 48.6 1.0 O B:HOH316 4.4 33.8 1.0 O B:MET237 4.5 30.6 1.0 CA B:HIS179 4.6 49.9 1.0 N B:ASN239 4.6 28.1 1.0 CA B:CYS242 4.6 26.3 1.0 O B:HOH302 4.7 22.8 1.0 O B:CYS176 4.7 34.2 1.0 C B:CYS238 4.8 31.6 1.0 C B:CYS176 4.9 35.2 1.0

W.S.Joo, P.D.Jeffrey, S.B.Cantor, M.S.Finnin, D.M.Livingston, N.P.Pavletich. Structure of the 53BP1 Brct Region Bound to P53 and Its Comparison to the BRCA1 Brct Structure. Genes Dev. V. 16 583 2002.
ISSN: ISSN 0890-9369
PubMed: 11877378
DOI: 10.1101/GAD.959202