Zinc in PDB 8wh6: Mpox E5 Hexamer Adp and Ssdna Bound and Clear Primase Domain Conformation

The binding sites of Zinc atom in the Mpox E5 Hexamer Adp and Ssdna Bound and Clear Primase Domain Conformation (pdb code 8wh6). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Mpox E5 Hexamer Adp and Ssdna Bound and Clear Primase Domain Conformation, PDB code: 8wh6:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Mpox E5 Hexamer Adp and Ssdna Bound and Clear Primase Domain Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Mpox E5 Hexamer Adp and Ssdna Bound and Clear Primase Domain Conformation within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn802 b:58.6 occ:1.00 NE2 D:HIS290 2.1 42.6 1.0 SG D:CYS285 2.3 37.8 1.0 SG D:CYS282 2.3 38.7 1.0 SG D:CYS314 2.3 36.7 1.0 CE1 D:HIS290 2.5 42.6 1.0 CB D:CYS282 2.7 38.7 1.0 CD2 D:HIS290 3.1 42.6 1.0 ND1 D:HIS290 3.5 42.6 1.0 CB D:CYS285 3.6 37.8 1.0 CG D:HIS290 3.8 42.6 1.0 CB D:CYS314 3.9 36.7 1.0 N D:CYS285 4.1 37.8 1.0 CA D:CYS282 4.2 38.7 1.0 CA D:CYS285 4.3 37.8 1.0 CA D:CYS314 4.4 36.7 1.0 CB D:LYS287 4.5 39.9 1.0 O D:SER313 4.6 32.9 1.0 C D:CYS285 4.8 37.8 1.0 N D:LYS287 4.8 39.9 1.0 NE2 D:HIS294 4.8 34.9 1.0 C D:CYS282 4.9 38.7 1.0 CB D:LEU284 5.0 39.8 1.0 C D:LEU284 5.0 39.8 1.0 N D:CYS314 5.0 36.7 1.0

Zinc binding site 2 out of 2 in the Mpox E5 Hexamer Adp and Ssdna Bound and Clear Primase Domain Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Mpox E5 Hexamer Adp and Ssdna Bound and Clear Primase Domain Conformation within 5.0Å range: probe atom residue distance (Å) B Occ E:Zn801 b:51.7 occ:1.00 SG E:CYS285 2.3 33.5 1.0 SG E:CYS282 2.3 31.6 1.0 SG E:CYS314 2.3 32.6 1.0 CB E:CYS285 2.5 33.5 1.0 N E:CYS285 2.9 33.5 1.0 CB E:CYS282 3.1 31.6 1.0 CA E:CYS285 3.2 33.5 1.0 CB E:CYS314 3.5 32.6 1.0 NE2 E:HIS290 3.7 36.8 1.0 CE1 E:HIS294 3.7 31.8 1.0 C E:LEU284 3.8 30.9 1.0 NE2 E:HIS294 3.8 31.8 1.0 CB E:LEU284 3.9 30.9 1.0 CD2 E:HIS290 4.1 36.8 1.0 CA E:LEU284 4.2 30.9 1.0 N E:LEU284 4.3 30.9 1.0 C E:CYS285 4.4 33.5 1.0 CA E:CYS314 4.4 32.6 1.0 CA E:CYS282 4.5 31.6 1.0 C E:CYS282 4.7 31.6 1.0 O E:LEU284 4.7 30.9 1.0 N E:LYS286 4.7 30.2 1.0 CE1 E:HIS290 4.8 36.8 1.0 O E:CYS282 4.9 31.6 1.0

Y.Xu, Y.Wu, Y.Zhang, K.Gao, X.Wu, Y.Yang, D.Li, B.Yang, Z.Zhang, C.Dong. Essential and Multifunctional Mpox Virus E5 Helicase-Primase in Double and Single Hexamer. Sci Adv V. 10 L1150 2024.
ISSN: ESSN 2375-2548
PubMed: 39167653
DOI: 10.1126/SCIADV.ADL1150