Zinc in PDB 8uqb: Crystal Structure of RNF168 (Ring)-UBCH5C Fused to H2A-H2B Via A 20- Residue Linker (Crystallization Condition 1)

Enzymatic activity of Crystal Structure of RNF168 (Ring)-UBCH5C Fused to H2A-H2B Via A 20- Residue Linker (Crystallization Condition 1)

All present enzymatic activity of Crystal Structure of RNF168 (Ring)-UBCH5C Fused to H2A-H2B Via A 20- Residue Linker (Crystallization Condition 1):
2.3.2.23; 2.3.2.24; 2.3.2.27;

Protein crystallography data

The structure of Crystal Structure of RNF168 (Ring)-UBCH5C Fused to H2A-H2B Via A 20- Residue Linker (Crystallization Condition 1), PDB code: 8uqb was solved by Q.Hu, M.V.Botuyan, G.Mer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.37 / 2.48
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 101.948, 101.948, 86.992, 90, 90, 120
R / Rfree (%) 21.8 / 26

Other elements in 8uqb:

The structure of Crystal Structure of RNF168 (Ring)-UBCH5C Fused to H2A-H2B Via A 20- Residue Linker (Crystallization Condition 1) also contains other interesting chemical elements:

Chlorine (Cl) 4 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of RNF168 (Ring)-UBCH5C Fused to H2A-H2B Via A 20- Residue Linker (Crystallization Condition 1) (pdb code 8uqb). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of RNF168 (Ring)-UBCH5C Fused to H2A-H2B Via A 20- Residue Linker (Crystallization Condition 1), PDB code: 8uqb:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 8uqb

Go back to Zinc Binding Sites List in 8uqb
Zinc binding site 1 out of 2 in the Crystal Structure of RNF168 (Ring)-UBCH5C Fused to H2A-H2B Via A 20- Residue Linker (Crystallization Condition 1)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of RNF168 (Ring)-UBCH5C Fused to H2A-H2B Via A 20- Residue Linker (Crystallization Condition 1) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn4001

b:50.3
occ:1.00
 ND1 A:HIS33 2.0 44.6 1.0
SG A:CYS51 2.3 45.0 1.0
SG A:CYS31 2.3 48.1 1.0
SG A:CYS54 2.3 47.5 1.0
CE1 A:HIS33 3.0 49.5 1.0
CG A:HIS33 3.0 52.2 1.0
CB A:CYS51 3.1 49.3 1.0
CB A:CYS31 3.2 54.2 1.0
CB A:HIS33 3.4 47.0 1.0
CB A:CYS54 3.6 36.3 1.0
N A:CYS54 3.9 48.7 1.0
NE2 A:HIS33 4.1 44.5 1.0
CD2 A:HIS33 4.1 43.9 1.0
CA A:CYS54 4.4 50.3 1.0
N A:HIS33 4.4 47.4 1.0
CB A:PHE53 4.5 47.2 1.0
CA A:HIS33 4.5 49.9 1.0
CA A:CYS31 4.5 48.1 1.0
CA A:CYS51 4.6 58.6 1.0
O A:CYS31 4.7 45.1 1.0
C A:CYS31 4.7 47.2 1.0
C A:PHE53 4.9 45.0 1.0
CB A:ARG56 5.0 64.9 1.0
C A:CYS54 5.0 47.9 1.0
CD2 A:PHE53 5.0 50.5 1.0
CD1 A:LEU29 5.0 61.1 1.0

Zinc binding site 2 out of 2 in 8uqb

Go back to Zinc Binding Sites List in 8uqb
Zinc binding site 2 out of 2 in the Crystal Structure of RNF168 (Ring)-UBCH5C Fused to H2A-H2B Via A 20- Residue Linker (Crystallization Condition 1)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of RNF168 (Ring)-UBCH5C Fused to H2A-H2B Via A 20- Residue Linker (Crystallization Condition 1) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn4002

b:75.4
occ:1.00
 SG A:CYS36 2.3 83.9 1.0
SG A:CYS16 2.3 68.4 1.0
SG A:CYS19 2.3 76.3 1.0
SG A:CYS39 2.3 65.3 1.0
CB A:CYS39 3.3 72.1 1.0
CB A:CYS19 3.4 65.7 1.0
CB A:CYS16 3.6 75.9 1.0
CB A:CYS36 3.7 66.1 1.0
N A:CYS19 3.8 62.2 1.0
N A:CYS36 4.0 64.5 1.0
CA A:CYS19 4.2 69.8 1.0
CB A:ILE18 4.4 53.1 1.0
CA A:CYS36 4.4 68.0 1.0
CA A:CYS39 4.5 71.7 1.0
N A:CYS39 4.5 75.2 1.0
C A:ILE18 4.8 60.9 1.0
N A:ILE18 4.9 61.1 1.0
O A:CYS36 4.9 67.3 1.0
CA A:ILE18 4.9 60.4 1.0
CA A:CYS16 5.0 69.5 1.0

Reference:

Q.Hu, M.V.Botuyan, G.Mer. Crystal Structure of RNF168 (Ring)-UBCH5C Fused to H2A-H2B Via A 20-Residue Linker (Crystallization Condition 1) To Be Published.
Page generated: Thu Oct 31 12:27:24 2024

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