Zinc in PDB 8u2y: Solution Structure of the PHD6 Finger of MLL4 Bound to TET3

All present enzymatic activity of Solution Structure of the PHD6 Finger of MLL4 Bound to TET3:
1.14.11.80; 2.1.1.364;

The binding sites of Zinc atom in the Solution Structure of the PHD6 Finger of MLL4 Bound to TET3 (pdb code 8u2y). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Solution Structure of the PHD6 Finger of MLL4 Bound to TET3, PDB code: 8u2y:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Solution Structure of the PHD6 Finger of MLL4 Bound to TET3


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Solution Structure of the PHD6 Finger of MLL4 Bound to TET3 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1601 b:0.0 occ:1.00 SG B:CYS1510 2.3 0.0 1.0 SG B:CYS1507 2.3 0.0 1.0 SG B:CYS1534 2.3 0.0 1.0 ND1 B:HIS1531 2.3 0.0 1.0 H B:HIS1531 2.6 0.0 1.0 HB3 B:CYS1507 2.9 0.0 1.0 CB B:CYS1507 3.0 0.0 1.0 HB2 B:HIS1531 3.1 0.0 1.0 HB3 B:CYS1534 3.2 0.0 1.0 HB2 B:CYS1507 3.2 0.0 1.0 HB B:ILE1509 3.2 0.0 1.0 CB B:CYS1534 3.2 0.0 1.0 CE1 B:HIS1531 3.3 0.0 1.0 CG B:HIS1531 3.4 0.0 1.0 H B:CYS1510 3.4 0.0 1.0 HB2 B:MET1530 3.4 0.0 1.0 HE1 B:HIS1531 3.4 0.0 1.0 HB2 B:CYS1534 3.5 0.0 1.0 N B:HIS1531 3.5 0.0 1.0 CB B:HIS1531 3.7 0.0 1.0 CB B:CYS1510 4.0 0.0 1.0 N B:CYS1510 4.1 0.0 1.0 HA B:MET1530 4.2 0.0 1.0 CA B:HIS1531 4.2 0.0 1.0 CB B:ILE1509 4.2 0.0 1.0 HB2 B:CYS1510 4.3 0.0 1.0 HD11 B:ILE1509 4.3 0.0 1.0 CB B:MET1530 4.4 0.0 1.0 HG21 B:ILE1509 4.4 0.0 1.0 H B:ILE1509 4.4 0.0 1.0 CA B:CYS1507 4.4 0.0 1.0 NE2 B:HIS1531 4.5 0.0 1.0 CD2 B:HIS1531 4.5 0.0 1.0 H B:CYS1534 4.5 0.0 1.0 O B:HIS1531 4.5 0.0 1.0 C B:MET1530 4.5 0.0 1.0 CA B:MET1530 4.6 0.0 1.0 CA B:CYS1510 4.6 0.0 1.0 HB3 B:HIS1531 4.6 0.0 1.0 CA B:CYS1534 4.7 0.0 1.0 HB3 B:CYS1510 4.7 0.0 1.0 HD13 B:ILE1509 4.7 0.0 1.0 CG2 B:ILE1509 4.8 0.0 1.0 HB3 B:MET1530 4.8 0.0 1.0 O B:CYS1510 4.8 0.0 1.0 C B:HIS1531 4.9 0.0 1.0 HG22 B:ILE1509 4.9 0.0 1.0 HA B:CYS1507 4.9 0.0 1.0 C B:CYS1507 4.9 0.0 1.0 CD1 B:ILE1509 4.9 0.0 1.0 C B:ILE1509 4.9 0.0 1.0 N B:ILE1509 4.9 0.0 1.0 HD2 B:PRO1508 5.0 0.0 1.0 CA B:ILE1509 5.0 0.0 1.0

Zinc binding site 2 out of 2 in the Solution Structure of the PHD6 Finger of MLL4 Bound to TET3


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Solution Structure of the PHD6 Finger of MLL4 Bound to TET3 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1602 b:0.0 occ:1.00 SG B:CYS1556 2.3 0.0 1.0 SG B:CYS1553 2.3 0.0 1.0 SG B:CYS1526 2.3 0.0 1.0 SG B:CYS1523 2.3 0.0 1.0 H B:CYS1553 2.9 0.0 1.0 HB2 B:HIS1525 2.9 0.0 1.0 HB2 B:CYS1526 3.3 0.0 1.0 H B:CYS1526 3.3 0.0 1.0 CB B:CYS1526 3.5 0.0 1.0 CB B:CYS1523 3.5 0.0 1.0 H B:CYS1556 3.5 0.0 1.0 HB3 B:CYS1523 3.5 0.0 1.0 CB B:CYS1553 3.6 0.0 1.0 HB3 B:CYS1553 3.7 0.0 1.0 HB2 B:CYS1523 3.7 0.0 1.0 CB B:CYS1556 3.7 0.0 1.0 N B:CYS1553 3.7 0.0 1.0 HB2 B:CYS1556 3.7 0.0 1.0 N B:CYS1526 3.8 0.0 1.0 HB2 B:SER1555 3.9 0.0 1.0 CB B:HIS1525 4.0 0.0 1.0 HA B:ASP1552 4.1 0.0 1.0 N B:CYS1556 4.2 0.0 1.0 HB3 B:HIS1525 4.2 0.0 1.0 CA B:CYS1553 4.2 0.0 1.0 HB3 B:CYS1526 4.3 0.0 1.0 CA B:CYS1526 4.3 0.0 1.0 CA B:CYS1556 4.4 0.0 1.0 HB2 B:CYS1553 4.5 0.0 1.0 HB3 B:CYS1556 4.5 0.0 1.0 H B:HIS1525 4.5 0.0 1.0 C B:HIS1525 4.5 0.0 1.0 HA B:CYS1556 4.5 0.0 1.0 HD2 B:HIS1525 4.6 0.0 1.0 CA B:HIS1525 4.7 0.0 1.0 O B:CYS1553 4.8 0.0 1.0 C B:ASP1552 4.8 0.0 1.0 C B:CYS1553 4.8 0.0 1.0 CA B:CYS1523 4.8 0.0 1.0 HA B:CYS1526 4.9 0.0 1.0 N B:HIS1525 4.9 0.0 1.0 HD2 B:ARG1528 4.9 0.0 1.0 H B:SER1555 4.9 0.0 1.0 CB B:SER1555 4.9 0.0 1.0 CG B:HIS1525 4.9 0.0 1.0 CA B:ASP1552 4.9 0.0 1.0

D.C.Becht, S.A.Mohid, J.E.Lee, M.Zandian, C.Benz, S.Biswas, V.K.Sinha, Y.Ivarsson, K.Ge, Y.Zhang, T.G.Kutateladze. MLL4 Binds TET3. Structure V. 32 706 2024.
ISSN: ISSN 0969-2126
PubMed: 38579707
DOI: 10.1016/J.STR.2024.03.005