Zinc in PDB 8sw1: Puromycin-Sensitive Aminopeptidase with Bound Peptide

All present enzymatic activity of Puromycin-Sensitive Aminopeptidase with Bound Peptide:
3.4.11.14;

The structure of Puromycin-Sensitive Aminopeptidase with Bound Peptide, PDB code: 8sw1 was solved by D.W.Rodgers, S.Madabushi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.52 / 3.65
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	70.745, 256.562, 60.279, 90, 90, 90
R / Rfree (%)	25.7 / 29.5

The binding sites of Zinc atom in the Puromycin-Sensitive Aminopeptidase with Bound Peptide (pdb code 8sw1). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Puromycin-Sensitive Aminopeptidase with Bound Peptide, PDB code: 8sw1:

Zinc binding site 1 out of 1 in the Puromycin-Sensitive Aminopeptidase with Bound Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Puromycin-Sensitive Aminopeptidase with Bound Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:140.4 occ:1.00 OE1 A:GLU375 2.3 136.8 1.0 NE2 A:HIS352 2.3 123.2 1.0 NE2 A:HIS356 2.3 117.6 1.0 CD2 A:HIS356 3.0 120.5 1.0 CD A:GLU375 3.1 131.7 1.0 CD2 A:HIS352 3.1 122.2 1.0 OE2 A:GLU375 3.2 136.3 1.0 O B:UNK1 3.3 180.7 1.0 CE1 A:HIS352 3.4 120.3 1.0 CE1 A:HIS356 3.4 112.0 1.0 OE1 A:GLU319 3.7 142.1 1.0 OE1 A:GLU353 3.8 134.7 1.0 CD A:GLU319 4.1 132.7 1.0 N B:UNK1 4.1 162.9 1.0 CG A:HIS356 4.2 113.8 1.0 OE2 A:GLU353 4.2 140.7 1.0 OE2 A:GLU319 4.2 135.6 1.0 C B:UNK1 4.3 201.3 1.0 ND1 A:HIS356 4.3 113.4 1.0 CG A:HIS352 4.3 117.8 1.0 CD A:GLU353 4.3 134.0 1.0 CB B:UNK1 4.4 186.5 1.0 ND1 A:HIS352 4.4 118.0 1.0 CA B:UNK1 4.5 187.9 1.0 CG A:GLU375 4.5 118.9 1.0 CB A:ALA378 4.8 111.0 1.0 CA A:GLU375 4.9 108.5 1.0 CB A:GLU375 5.0 113.9 1.0 CG A:GLU319 5.0 114.6 1.0

S.Madabushi, K.M.Chow, E.S.Song, A.Goswami, L.B.Hersh, D.W.Rodgers. Structure of Puromycin-Sensitive Aminopeptidase and Polyglutamine Binding. Plos One V. 18 87086 2023.
ISSN: ESSN 1932-6203
PubMed: 37440518
DOI: 10.1371/JOURNAL.PONE.0287086