Zinc in PDB 8rm7: Crystal Structure of Human Androgen Receptor Dna Binding Domain Bound to Its Response Element: Mmtv-177 Gre/Are

Protein crystallography data

The structure of Crystal Structure of Human Androgen Receptor Dna Binding Domain Bound to Its Response Element: Mmtv-177 Gre/Are, PDB code: 8rm7 was solved by X.Y.Lee, C.Helsen, W.Van Eynde, A.Voet, F.Claessens, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.17 / 2.25
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 137.91, 29.78, 112.609, 90, 124.91, 90
R / Rfree (%) 26.7 / 31

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Human Androgen Receptor Dna Binding Domain Bound to Its Response Element: Mmtv-177 Gre/Are (pdb code 8rm7). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of Human Androgen Receptor Dna Binding Domain Bound to Its Response Element: Mmtv-177 Gre/Are, PDB code: 8rm7:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 8rm7

Go back to Zinc Binding Sites List in 8rm7
Zinc binding site 1 out of 4 in the Crystal Structure of Human Androgen Receptor Dna Binding Domain Bound to Its Response Element: Mmtv-177 Gre/Are


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human Androgen Receptor Dna Binding Domain Bound to Its Response Element: Mmtv-177 Gre/Are within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn701

b:25.6
occ:1.00
SG B:CYS601 2.3 21.6 1.0
SG B:CYS595 2.3 35.4 1.0
SG B:CYS614 2.3 28.5 1.0
SG B:CYS611 2.3 23.3 1.0
CB B:CYS595 3.3 33.4 1.0
CB B:CYS601 3.3 29.7 1.0
CB B:CYS611 3.4 25.7 1.0
CB B:CYS614 3.4 27.5 1.0
O B:HOH802 3.8 42.0 1.0
N B:CYS601 3.9 33.2 1.0
O A:HOH809 3.9 25.8 1.0
CA B:CYS595 4.1 37.5 1.0
N B:CYS614 4.2 26.4 1.0
CA B:CYS601 4.2 31.1 1.0
CA B:ASN599 4.3 35.9 1.0
CA B:CYS614 4.4 26.1 1.0
N B:ASP600 4.4 31.3 1.0
N B:ASN599 4.4 41.1 1.0
C B:ASN599 4.7 34.0 1.0
CA B:CYS611 4.8 28.1 1.0
N B:ALA596 4.8 35.9 1.0
O B:HOH830 4.8 29.7 1.0
C B:CYS595 5.0 35.0 1.0
C B:ASP600 5.0 34.1 1.0

Zinc binding site 2 out of 4 in 8rm7

Go back to Zinc Binding Sites List in 8rm7
Zinc binding site 2 out of 4 in the Crystal Structure of Human Androgen Receptor Dna Binding Domain Bound to Its Response Element: Mmtv-177 Gre/Are


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Human Androgen Receptor Dna Binding Domain Bound to Its Response Element: Mmtv-177 Gre/Are within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn702

b:26.8
occ:1.00
SG B:CYS579 2.3 20.8 1.0
SG B:CYS559 2.3 21.8 1.0
SG B:CYS562 2.3 22.8 1.0
SG B:CYS576 2.3 20.2 1.0
CB B:CYS559 3.2 32.2 1.0
CB B:CYS579 3.2 24.9 1.0
CB B:CYS562 3.4 27.8 1.0
CB B:CYS576 3.6 29.7 1.0
N B:CYS562 3.8 30.0 1.0
N B:CYS576 4.0 32.8 1.0
CA B:CYS562 4.1 31.5 1.0
N B:CYS579 4.2 29.2 1.0
NH1 B:ARG608 4.2 37.4 1.0
CA B:CYS579 4.3 26.3 1.0
CA B:CYS576 4.3 32.0 1.0
CB B:ILE561 4.6 29.8 1.0
CB B:ASP564 4.6 40.8 1.0
CA B:CYS559 4.6 36.9 1.0
NH2 B:ARG615 4.7 21.5 1.0
N B:GLY563 4.7 35.6 1.0
C B:CYS562 4.7 29.2 1.0
C B:ILE561 4.8 33.2 1.0
N B:ASP564 4.9 35.6 1.0
CD B:ARG608 4.9 32.4 1.0
C B:CYS576 4.9 25.7 1.0
O B:CYS576 5.0 20.7 1.0
CG2 B:ILE561 5.0 26.2 1.0

Zinc binding site 3 out of 4 in 8rm7

Go back to Zinc Binding Sites List in 8rm7
Zinc binding site 3 out of 4 in the Crystal Structure of Human Androgen Receptor Dna Binding Domain Bound to Its Response Element: Mmtv-177 Gre/Are


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of Human Androgen Receptor Dna Binding Domain Bound to Its Response Element: Mmtv-177 Gre/Are within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn701

b:29.9
occ:1.00
SG A:CYS601 2.3 33.1 1.0
SG A:CYS611 2.3 33.1 1.0
SG A:CYS595 2.3 35.8 1.0
SG A:CYS614 2.3 37.0 1.0
CB A:CYS601 3.2 33.5 1.0
CB A:CYS611 3.3 31.4 1.0
CB A:CYS595 3.3 36.7 1.0
CB A:CYS614 3.4 37.3 1.0
N A:CYS601 3.9 48.4 1.0
CA A:CYS595 4.2 35.4 1.0
O A:HOH812 4.2 27.6 1.0
CA A:CYS601 4.2 35.2 1.0
N A:CYS614 4.2 36.4 1.0
CA A:ASN599 4.3 46.8 1.0
CA A:CYS614 4.4 37.1 1.0
N A:ASN599 4.4 43.5 1.0
N A:ASP600 4.5 53.7 1.0
O A:HOH803 4.5 42.7 1.0
C A:ASN599 4.7 47.4 1.0
CA A:CYS611 4.7 35.5 1.0
N A:ALA596 4.9 33.1 1.0
C A:CYS595 4.9 35.7 1.0
CB A:SER597 5.0 34.3 1.0

Zinc binding site 4 out of 4 in 8rm7

Go back to Zinc Binding Sites List in 8rm7
Zinc binding site 4 out of 4 in the Crystal Structure of Human Androgen Receptor Dna Binding Domain Bound to Its Response Element: Mmtv-177 Gre/Are


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of Human Androgen Receptor Dna Binding Domain Bound to Its Response Element: Mmtv-177 Gre/Are within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn702

b:32.5
occ:0.85
SG A:CYS562 2.3 39.9 1.0
SG A:CYS579 2.3 35.7 1.0
SG A:CYS576 2.3 45.9 1.0
SG A:CYS559 2.3 44.1 1.0
CB A:CYS559 3.2 50.3 1.0
CB A:CYS579 3.2 37.5 1.0
CB A:CYS562 3.3 44.4 1.0
CB A:CYS576 3.7 44.3 1.0
N A:CYS562 3.7 50.2 1.0
N A:CYS576 3.9 44.4 1.0
CA A:CYS562 4.1 45.1 1.0
N A:CYS579 4.1 41.2 1.0
CA A:CYS579 4.3 43.6 1.0
NH1 A:ARG608 4.3 38.0 1.0
CA A:CYS576 4.4 42.4 1.0
CB A:ASP564 4.6 48.3 1.0
CB A:ILE561 4.6 42.9 1.0
CA A:CYS559 4.7 49.0 1.0
N A:GLY563 4.7 48.4 1.0
C A:CYS562 4.7 47.7 1.0
C A:ILE561 4.8 47.7 1.0
N A:ASP564 4.8 47.9 1.0
NH2 A:ARG615 4.8 36.7 1.0
CD A:ARG608 5.0 34.5 1.0
CG2 A:ILE561 5.0 45.8 1.0
C A:THR575 5.0 48.9 1.0
C A:CYS576 5.0 41.0 1.0

Reference:

X.Y.Lee, W.Van Eynde, C.Helsen, H.Willems, K.Peperstraete, S.De Block, A.Voet, F.Claessens. Structural Mechanism Underlying Variations in Dna Binding By the Androgen Receptor. J.Steroid Biochem.Mol.Biol. V. 241 06499 2024.
ISSN: ISSN 0960-0760
PubMed: 38604378
DOI: 10.1016/J.JSBMB.2024.106499
Page generated: Thu Oct 31 10:33:35 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy