Zinc in PDB 8qu8: Protac-Mediated Complex of Kras with Vhl/Elongin-B/Elongin-C/Cullin- 2/RBX1

All present enzymatic activity of Protac-Mediated Complex of Kras with Vhl/Elongin-B/Elongin-C/Cullin- 2/RBX1:
3.6.5.2;

The binding sites of Zinc atom in the Protac-Mediated Complex of Kras with Vhl/Elongin-B/Elongin-C/Cullin- 2/RBX1 (pdb code 8qu8). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Protac-Mediated Complex of Kras with Vhl/Elongin-B/Elongin-C/Cullin- 2/RBX1, PDB code: 8qu8:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Protac-Mediated Complex of Kras with Vhl/Elongin-B/Elongin-C/Cullin- 2/RBX1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Protac-Mediated Complex of Kras with Vhl/Elongin-B/Elongin-C/Cullin- 2/RBX1 within 5.0Å range: probe atom residue distance (Å) B Occ E:Zn201 b:256.3 occ:1.00 ND1 E:HIS80 2.1 227.9 1.0 SG E:CYS42 2.3 215.1 1.0 SG E:CYS45 2.3 207.0 1.0 SG E:CYS83 2.3 232.8 1.0 CB E:CYS42 2.3 215.1 1.0 CE1 E:HIS80 2.6 227.9 1.0 CB E:CYS83 2.8 232.8 1.0 CG E:HIS80 3.3 227.9 1.0 CB E:CYS45 3.7 207.0 1.0 NE2 E:HIS80 3.8 227.9 1.0 CA E:CYS42 3.8 215.1 1.0 CB E:HIS80 4.0 227.9 1.0 CD2 E:HIS80 4.1 227.9 1.0 CA E:CYS83 4.3 232.8 1.0 N E:ALA43 4.5 198.7 1.0 O E:ASN41 4.5 215.2 1.0 N E:CYS42 4.5 215.1 1.0 N E:CYS45 4.6 207.0 1.0 C E:CYS42 4.7 215.1 1.0 CA E:CYS45 4.8 207.0 1.0 C E:ASN41 4.8 215.2 1.0

Zinc binding site 2 out of 2 in the Protac-Mediated Complex of Kras with Vhl/Elongin-B/Elongin-C/Cullin- 2/RBX1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Protac-Mediated Complex of Kras with Vhl/Elongin-B/Elongin-C/Cullin- 2/RBX1 within 5.0Å range: probe atom residue distance (Å) B Occ E:Zn202 b:261.8 occ:1.00 CB E:CYS56 1.9 236.6 1.0 NE2 E:HIS82 2.1 227.3 1.0 SG E:CYS68 2.3 220.3 1.0 SG E:CYS56 2.3 236.6 1.0 SG E:CYS53 2.3 228.2 1.0 CE1 E:HIS82 2.4 227.3 1.0 CD2 E:HIS82 3.1 227.3 1.0 CA E:CYS56 3.2 236.6 1.0 ND1 E:HIS82 3.4 227.3 1.0 N E:CYS56 3.5 236.6 1.0 O E:CYS53 3.7 228.2 1.0 CG E:HIS82 3.7 227.3 1.0 CB E:CYS53 3.9 228.2 1.0 CB E:CYS68 3.9 220.3 1.0 N E:CYS53 4.0 228.2 1.0 CA E:CYS53 4.3 228.2 1.0 C E:CYS53 4.3 228.2 1.0 C E:CYS56 4.4 236.6 1.0 O E:CYS56 4.8 236.6 1.0 C E:GLU55 4.8 225.9 1.0 CA E:CYS68 4.9 220.3 1.0 O E:CYS68 5.0 220.3 1.0

J.Popow, W.Farnaby, A.Gollner, C.Kofink, G.Fischer, M.Wurm, D.Zollman, A.Wijaya, N.Mischerikow, C.Hasenoehrl, P.Prokofeva, H.Arnhof, S.Arce-Solano, S.Bell, G.Boeck, E.Diers, A.Frost, J.Goodwin-Tindall, J.Karolyi-Oezguer, S.Khan, T.Klawatsch, M.Koegl, R.Kousek, B.Kratochvil, K.Kropatsch, A.Lauber, R.Mclennan, S.Olt, D.Peter, O.Petermann, V.Roessler, P.Stolt-Bergner, P.Strack, E.Strauss, N.Trainor, V.Vetma, C.Whitworth, S.Zhong, J.Quant, H.Weinstabl, B.Kuster, P.Ettmayer, A.Ciulli. Targeting Cancer with Small Molecule Pan-Kras Degraders Biorxiv 2023.
ISSN: ISSN 2692-8205
DOI: 10.1101/2023.10.24.563163