Zinc in PDB 8gin: Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Atp: with 10MM MG2+ and 0.015MM MN2+

Enzymatic activity of Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Atp: with 10MM MG2+ and 0.015MM MN2+

All present enzymatic activity of Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Atp: with 10MM MG2+ and 0.015MM MN2+:
2.7.7.86;

Protein crystallography data

The structure of Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Atp: with 10MM MG2+ and 0.015MM MN2+, PDB code: 8gin was solved by S.Wu, J.Sohn, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.78 / 2.75
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 77.392, 98.709, 142.26, 90, 90, 90
R / Rfree (%) 18.1 / 22.5

Other elements in 8gin:

The structure of Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Atp: with 10MM MG2+ and 0.015MM MN2+ also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms
Manganese (Mn) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Atp: with 10MM MG2+ and 0.015MM MN2+ (pdb code 8gin). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Atp: with 10MM MG2+ and 0.015MM MN2+, PDB code: 8gin:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 8gin

Go back to Zinc Binding Sites List in 8gin
Zinc binding site 1 out of 2 in the Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Atp: with 10MM MG2+ and 0.015MM MN2+


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Atp: with 10MM MG2+ and 0.015MM MN2+ within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn602

b:46.6
occ:1.00
NE2 A:HIS378 2.0 45.9 1.0
SG A:CYS385 2.3 50.0 1.0
SG A:CYS392 2.3 46.1 1.0
SG A:CYS384 2.4 44.3 1.0
CD2 A:HIS378 2.8 42.2 1.0
CE1 A:HIS378 3.1 42.2 1.0
CB A:CYS392 3.2 45.4 1.0
CB A:CYS385 3.4 43.5 1.0
CB A:CYS384 3.6 38.6 1.0
N A:CYS392 3.8 43.8 1.0
N A:CYS385 3.9 40.7 1.0
C A:CYS384 3.9 41.3 1.0
CA A:CYS392 4.0 44.1 1.0
CG A:HIS378 4.0 44.1 1.0
ND1 A:HIS378 4.1 41.5 1.0
CA A:CYS385 4.2 40.7 1.0
O A:CYS384 4.2 42.9 1.0
CA A:CYS384 4.3 39.1 1.0
NH1 A:ARG394 4.4 40.7 1.0
C A:CYS392 4.6 45.0 1.0
O A:CYS392 4.8 50.7 1.0
O A:ALA390 4.9 46.8 1.0
C A:LYS391 4.9 48.5 1.0

Zinc binding site 2 out of 2 in 8gin

Go back to Zinc Binding Sites List in 8gin
Zinc binding site 2 out of 2 in the Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Atp: with 10MM MG2+ and 0.015MM MN2+


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Atp: with 10MM MG2+ and 0.015MM MN2+ within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn602

b:49.6
occ:1.00
NE2 C:HIS378 2.1 49.1 1.0
SG C:CYS385 2.3 51.7 1.0
SG C:CYS384 2.3 50.6 1.0
SG C:CYS392 2.4 49.5 1.0
CD2 C:HIS378 3.0 46.2 1.0
CE1 C:HIS378 3.2 45.3 1.0
CB C:CYS385 3.3 48.4 1.0
CB C:CYS392 3.4 53.1 1.0
O C:HOH710 3.6 46.6 1.0
N C:CYS392 3.7 48.4 1.0
CB C:CYS384 3.7 45.4 1.0
N C:CYS385 3.9 49.8 1.0
C C:CYS384 3.9 47.0 1.0
CA C:CYS392 4.0 51.1 1.0
CA C:CYS385 4.1 49.2 1.0
CG C:HIS378 4.2 46.8 1.0
ND1 C:HIS378 4.3 45.2 1.0
O C:CYS384 4.3 46.3 1.0
CA C:CYS384 4.4 44.9 1.0
NH1 C:ARG394 4.4 48.5 1.0
C C:CYS392 4.5 50.9 1.0
O C:CYS392 4.6 52.1 1.0
O C:ALA390 4.8 55.9 1.0
C C:LYS391 4.8 50.0 1.0

Reference:

S.Wu, S.B.Gabelli, J.Sohn. The Structural Basis For 2'-5'/3'-5'-Cgamp Synthesis By Cgas Nat Commun V. 15 4012 2024.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-024-48365-3
Page generated: Wed Oct 30 20:52:24 2024

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