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Atomistry » Zinc » PDB 8f8o-8fiy » 8fgm | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 8f8o-8fiy » 8fgm » |
Zinc in PDB 8fgm: Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 4-(Difluoromethyl)-6-(5-(2- (Dimethylamino)Ethyl)-2,3-Difluorophenethyl)Pyridin-2-AmineEnzymatic activity of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 4-(Difluoromethyl)-6-(5-(2- (Dimethylamino)Ethyl)-2,3-Difluorophenethyl)Pyridin-2-Amine
All present enzymatic activity of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 4-(Difluoromethyl)-6-(5-(2- (Dimethylamino)Ethyl)-2,3-Difluorophenethyl)Pyridin-2-Amine:
1.14.13.39; Protein crystallography data
The structure of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 4-(Difluoromethyl)-6-(5-(2- (Dimethylamino)Ethyl)-2,3-Difluorophenethyl)Pyridin-2-Amine, PDB code: 8fgm
was solved by
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 8fgm:
The structure of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 4-(Difluoromethyl)-6-(5-(2- (Dimethylamino)Ethyl)-2,3-Difluorophenethyl)Pyridin-2-Amine also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 4-(Difluoromethyl)-6-(5-(2- (Dimethylamino)Ethyl)-2,3-Difluorophenethyl)Pyridin-2-Amine
(pdb code 8fgm). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 4-(Difluoromethyl)-6-(5-(2- (Dimethylamino)Ethyl)-2,3-Difluorophenethyl)Pyridin-2-Amine, PDB code: 8fgm: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 8fgmGo back to Zinc Binding Sites List in 8fgm
Zinc binding site 1 out
of 2 in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 4-(Difluoromethyl)-6-(5-(2- (Dimethylamino)Ethyl)-2,3-Difluorophenethyl)Pyridin-2-Amine
Mono view Stereo pair view
Zinc binding site 2 out of 2 in 8fgmGo back to Zinc Binding Sites List in 8fgm
Zinc binding site 2 out
of 2 in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 4-(Difluoromethyl)-6-(5-(2- (Dimethylamino)Ethyl)-2,3-Difluorophenethyl)Pyridin-2-Amine
Mono view Stereo pair view
Reference:
D.Vasu,
H.T.Do,
H.Li,
C.D.Hardy,
A.Awasthi,
T.L.Poulos,
R.B.Silverman.
Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors. J.Med.Chem. V. 66 9934 2023.
Page generated: Thu Dec 28 13:00:29 2023
ISSN: ISSN 0022-2623 PubMed: 37433128 DOI: 10.1021/ACS.JMEDCHEM.3C00782 |
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