Zinc in PDB 8f86: SIRT6 Bound to An H3K9AC Nucleosome

All present enzymatic activity of SIRT6 Bound to An H3K9AC Nucleosome:
2.3.1.286;

The binding sites of Zinc atom in the SIRT6 Bound to An H3K9AC Nucleosome (pdb code 8f86). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the SIRT6 Bound to An H3K9AC Nucleosome, PDB code: 8f86:

Zinc binding site 1 out of 1 in the SIRT6 Bound to An H3K9AC Nucleosome


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of SIRT6 Bound to An H3K9AC Nucleosome within 5.0Å range: probe atom residue distance (Å) B Occ K:Zn401 b:135.0 occ:1.00 SG K:CYS141 2.3 144.8 1.0 SG K:CYS166 2.3 126.4 1.0 SG K:CYS144 2.3 126.5 1.0 SG K:CYS177 2.3 122.4 1.0 CB K:CYS166 3.0 117.5 1.0 CB K:CYS141 3.2 132.6 1.0 CB K:CYS144 3.4 126.3 1.0 CB K:CYS177 3.6 116.9 1.0 N K:CYS144 3.7 119.1 1.0 CG1 K:VAL168 4.0 110.4 1.0 CA K:CYS144 4.1 124.2 1.0 CA K:CYS166 4.4 111.6 1.0 OG1 K:THR146 4.5 124.5 1.0 CB K:LYS143 4.5 115.4 1.0 C K:CYS177 4.5 111.3 1.0 N K:GLY179 4.6 129.1 1.0 CA K:CYS141 4.6 126.4 1.0 O K:CYS177 4.6 115.1 1.0 CA K:CYS177 4.7 108.9 1.0 C K:LYS143 4.7 114.2 1.0 N K:LYS143 4.8 125.2 1.0 C K:CYS144 4.9 122.5 1.0 N K:ARG178 4.9 121.2 1.0 OH K:TYR148 4.9 135.0 1.0 CA K:LYS143 4.9 117.0 1.0 CA K:GLY179 5.0 129.4 1.0

Z.A.Wang, J.W.Markert, S.D.Whedon, M.Yapa Abeywardana, K.Lee, H.Jiang, C.Suarez, H.Lin, L.Farnung, P.A.Cole. Structural Basis of Sirtuin 6-Catalyzed Nucleosome Deacetylation. J.Am.Chem.Soc. V. 145 6811 2023.
ISSN: ESSN 1520-5126
PubMed: 36930461
DOI: 10.1021/JACS.2C13512