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Zinc in PDB 8exg: Human Carbonic Anhydrase II Bound N-(2-(2-((2-(2,6-Dioxopiperidin-3- Yl)-1,3-Dioxoisoindolin-4-Yl)Amino)Ethoxy)Ethyl)-4-SulfamoylbenzamideEnzymatic activity of Human Carbonic Anhydrase II Bound N-(2-(2-((2-(2,6-Dioxopiperidin-3- Yl)-1,3-Dioxoisoindolin-4-Yl)Amino)Ethoxy)Ethyl)-4-Sulfamoylbenzamide
All present enzymatic activity of Human Carbonic Anhydrase II Bound N-(2-(2-((2-(2,6-Dioxopiperidin-3- Yl)-1,3-Dioxoisoindolin-4-Yl)Amino)Ethoxy)Ethyl)-4-Sulfamoylbenzamide:
4.2.1.1; Protein crystallography data
The structure of Human Carbonic Anhydrase II Bound N-(2-(2-((2-(2,6-Dioxopiperidin-3- Yl)-1,3-Dioxoisoindolin-4-Yl)Amino)Ethoxy)Ethyl)-4-Sulfamoylbenzamide, PDB code: 8exg
was solved by
A.J.Kohlbrand,
C.B.O'herin,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 8exg:
The structure of Human Carbonic Anhydrase II Bound N-(2-(2-((2-(2,6-Dioxopiperidin-3- Yl)-1,3-Dioxoisoindolin-4-Yl)Amino)Ethoxy)Ethyl)-4-Sulfamoylbenzamide also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Human Carbonic Anhydrase II Bound N-(2-(2-((2-(2,6-Dioxopiperidin-3- Yl)-1,3-Dioxoisoindolin-4-Yl)Amino)Ethoxy)Ethyl)-4-Sulfamoylbenzamide
(pdb code 8exg). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Human Carbonic Anhydrase II Bound N-(2-(2-((2-(2,6-Dioxopiperidin-3- Yl)-1,3-Dioxoisoindolin-4-Yl)Amino)Ethoxy)Ethyl)-4-Sulfamoylbenzamide, PDB code: 8exg: Zinc binding site 1 out of 1 in 8exgGo back to Zinc Binding Sites List in 8exg
Zinc binding site 1 out
of 1 in the Human Carbonic Anhydrase II Bound N-(2-(2-((2-(2,6-Dioxopiperidin-3- Yl)-1,3-Dioxoisoindolin-4-Yl)Amino)Ethoxy)Ethyl)-4-Sulfamoylbenzamide
Mono view Stereo pair view
Reference:
C.B.O'herin,
Y.W.Moriuchi,
T.A.Bemis,
A.J.Kohlbrand,
M.D.Burkart,
S.M.Cohen.
Development of Human Carbonic Anhydrase II Heterobifunctional Degraders. J.Med.Chem. 2023.
Page generated: Sat Apr 8 08:50:06 2023
ISSN: ISSN 0022-2623 PubMed: 36735827 DOI: 10.1021/ACS.JMEDCHEM.2C01843 |
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