Zinc in PDB 8e9e: Rat Protein Farnesyltransferase in Complex with Fpp and Inhibitor 2F

Enzymatic activity of Rat Protein Farnesyltransferase in Complex with Fpp and Inhibitor 2F

All present enzymatic activity of Rat Protein Farnesyltransferase in Complex with Fpp and Inhibitor 2F:
2.5.1.58; 2.5.1.59;

Protein crystallography data

The structure of Rat Protein Farnesyltransferase in Complex with Fpp and Inhibitor 2F, PDB code: 8e9e was solved by Y.Wang, Y.Shi, L.S.Beese, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.38 / 2.84
Space group P 61
Cell size a, b, c (Å), α, β, γ (°) 169.898, 169.898, 69.339, 90, 90, 120
R / Rfree (%) 17.6 / 19.4

Other elements in 8e9e:

The structure of Rat Protein Farnesyltransferase in Complex with Fpp and Inhibitor 2F also contains other interesting chemical elements:

Fluorine (F) 3 atoms
Bromine (Br) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Rat Protein Farnesyltransferase in Complex with Fpp and Inhibitor 2F (pdb code 8e9e). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Rat Protein Farnesyltransferase in Complex with Fpp and Inhibitor 2F, PDB code: 8e9e:

Zinc binding site 1 out of 1 in 8e9e

Go back to Zinc Binding Sites List in 8e9e
Zinc binding site 1 out of 1 in the Rat Protein Farnesyltransferase in Complex with Fpp and Inhibitor 2F


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Rat Protein Farnesyltransferase in Complex with Fpp and Inhibitor 2F within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn502

b:35.2
occ:1.00
 N15 B:XMY503 2.0 40.9 1.0
OD2 B:ASP297 2.1 46.6 1.0
NE2 B:HIS362 2.2 38.9 1.0
SG B:CYS299 2.3 35.4 1.0
OD1 B:ASP297 2.5 34.6 1.0
CG B:ASP297 2.6 37.5 1.0
C14 B:XMY503 3.0 42.0 1.0
CD2 B:HIS362 3.0 38.2 1.0
C16 B:XMY503 3.0 39.9 1.0
CE1 B:HIS362 3.2 43.4 1.0
CB B:CYS299 3.4 35.4 1.0
CE2 B:TYR361 3.7 36.3 1.0
CB B:ASP297 4.0 36.6 1.0
N17 B:XMY503 4.2 40.1 1.0
C13 B:XMY503 4.2 39.2 1.0
CG B:HIS362 4.2 35.5 1.0
N B:CYS299 4.2 37.9 1.0
ND1 B:HIS362 4.2 36.0 1.0
O B:HOH604 4.4 29.9 1.0
CA B:CYS299 4.4 37.5 1.0
OH B:TYR361 4.4 31.8 1.0
CB B:ASP352 4.5 34.3 1.0
CD2 B:TYR361 4.6 36.0 1.0
CZ B:TYR361 4.6 34.8 1.0
CG B:ASP352 4.7 41.1 1.0
OD2 B:ASP352 4.9 45.7 1.0
CA B:ASP352 5.0 35.4 1.0
CZ B:TYR300 5.0 36.6 1.0

Reference:

Y.Wang, F.Xu, C.B.Nichols, Y.Shi, H.W.Hellinga, J.A.Alspaugh, M.D.Distefano, L.S.Beese. Structure-Guided Discovery of Potent Antifungals That Prevent Ras Signaling By Inhibiting Protein Farnesyltransferase. J.Med.Chem. V. 65 13753 2022.
ISSN: ISSN 0022-2623
PubMed: 36218371
DOI: 10.1021/ACS.JMEDCHEM.2C00902
Page generated: Wed Oct 30 19:34:21 2024

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