Zinc in PDB 8atc: Complex of N-Phosphonacetyl-L-Aspartate with Aspartate Carbamoyltransferase. X-Ray Refinement, Analysis of Conformational Changes and Catalytic and Allosteric Mechanisms

Enzymatic activity of Complex of N-Phosphonacetyl-L-Aspartate with Aspartate Carbamoyltransferase. X-Ray Refinement, Analysis of Conformational Changes and Catalytic and Allosteric Mechanisms

All present enzymatic activity of Complex of N-Phosphonacetyl-L-Aspartate with Aspartate Carbamoyltransferase. X-Ray Refinement, Analysis of Conformational Changes and Catalytic and Allosteric Mechanisms:
2.1.3.2;

Protein crystallography data

The structure of Complex of N-Phosphonacetyl-L-Aspartate with Aspartate Carbamoyltransferase. X-Ray Refinement, Analysis of Conformational Changes and Catalytic and Allosteric Mechanisms, PDB code: 8atc was solved by H.Ke, W.N.Lipscomb, Y.Cho, R.B.Honzatko, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 8.00 / 2.50
Space group P 3 2 1
Cell size a, b, c (Å), α, β, γ (°) 122.110, 122.110, 156.170, 90.00, 90.00, 120.00
R / Rfree (%) n/a / n/a

Zinc Binding Sites:

The binding sites of Zinc atom in the Complex of N-Phosphonacetyl-L-Aspartate with Aspartate Carbamoyltransferase. X-Ray Refinement, Analysis of Conformational Changes and Catalytic and Allosteric Mechanisms (pdb code 8atc). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Complex of N-Phosphonacetyl-L-Aspartate with Aspartate Carbamoyltransferase. X-Ray Refinement, Analysis of Conformational Changes and Catalytic and Allosteric Mechanisms, PDB code: 8atc:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 8atc

Go back to Zinc Binding Sites List in 8atc
Zinc binding site 1 out of 2 in the Complex of N-Phosphonacetyl-L-Aspartate with Aspartate Carbamoyltransferase. X-Ray Refinement, Analysis of Conformational Changes and Catalytic and Allosteric Mechanisms


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Complex of N-Phosphonacetyl-L-Aspartate with Aspartate Carbamoyltransferase. X-Ray Refinement, Analysis of Conformational Changes and Catalytic and Allosteric Mechanisms within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn154

b:30.0
occ:1.00
SG B:CYS138 2.0 25.1 1.0
SG B:CYS114 2.0 28.9 1.0
SG B:CYS109 2.1 26.1 1.0
SG B:CYS141 2.1 24.7 1.0
CB B:CYS138 2.9 26.7 1.0
CB B:CYS109 3.2 29.5 1.0
CB B:CYS114 3.3 30.2 1.0
CB B:CYS141 3.4 23.8 1.0
N B:CYS141 3.7 24.2 1.0
CA B:CYS141 4.1 25.1 1.0
CA B:CYS138 4.3 29.3 1.0
O B:HOH180 4.4 22.8 1.0
CB B:ASN111 4.5 26.5 1.0
CA B:CYS109 4.5 33.7 1.0
CA B:CYS114 4.6 31.3 1.0
ND2 B:ASN111 4.6 21.4 1.0
CB B:TYR140 4.6 21.8 1.0
CB B:SER116 4.7 32.1 1.0
O B:ASN111 4.8 34.6 1.0
OG B:SER116 4.8 35.6 1.0
C B:TYR140 4.9 23.9 1.0
C B:CYS138 4.9 29.7 1.0

Zinc binding site 2 out of 2 in 8atc

Go back to Zinc Binding Sites List in 8atc
Zinc binding site 2 out of 2 in the Complex of N-Phosphonacetyl-L-Aspartate with Aspartate Carbamoyltransferase. X-Ray Refinement, Analysis of Conformational Changes and Catalytic and Allosteric Mechanisms


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Complex of N-Phosphonacetyl-L-Aspartate with Aspartate Carbamoyltransferase. X-Ray Refinement, Analysis of Conformational Changes and Catalytic and Allosteric Mechanisms within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn154

b:35.1
occ:1.00
SG D:CYS141 2.0 29.0 1.0
SG D:CYS109 2.0 33.1 1.0
SG D:CYS114 2.1 28.5 1.0
SG D:CYS138 2.1 28.5 1.0
CB D:CYS138 2.9 29.5 1.0
CB D:CYS109 3.3 37.8 1.0
CB D:CYS141 3.3 28.2 1.0
CB D:CYS114 3.3 29.8 1.0
N D:CYS141 3.7 29.0 1.0
CA D:CYS141 4.0 29.9 1.0
CB D:ASN111 4.3 33.5 1.0
CA D:CYS138 4.4 30.9 1.0
CA D:CYS114 4.5 29.6 1.0
CB D:TYR140 4.5 20.6 1.0
O D:HOH806 4.6 14.4 1.0
CA D:CYS109 4.7 41.7 1.0
CZ D:PHE145 4.7 59.1 1.0
CB D:SER116 4.7 32.5 1.0
CE1 D:PHE145 4.8 58.0 1.0
C D:TYR140 4.8 26.8 1.0
ND2 D:ASN111 4.8 32.5 1.0
C D:CYS141 4.9 30.7 1.0
C D:CYS138 5.0 30.5 1.0

Reference:

H.M.Ke, W.N.Lipscomb, Y.J.Cho, R.B.Honzatko. Complex of N-Phosphonacetyl-L-Aspartate with Aspartate Carbamoyltransferase. X-Ray Refinement, Analysis of Conformational Changes and Catalytic and Allosteric Mechanisms. J.Mol.Biol. V. 204 725 1988.
ISSN: ISSN 0022-2836
PubMed: 3066911
DOI: 10.1016/0022-2836(88)90365-8
Page generated: Wed Dec 16 14:05:10 2020

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