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Zinc in PDB 8aoq: Cereblon Isoform 4 From Magnetospirillum Gryphiswaldense in Complex with Compound 20AProtein crystallography data
The structure of Cereblon Isoform 4 From Magnetospirillum Gryphiswaldense in Complex with Compound 20A, PDB code: 8aoq
was solved by
S.Maiwald,
C.Heim,
M.D.Hartmann,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Cereblon Isoform 4 From Magnetospirillum Gryphiswaldense in Complex with Compound 20A
(pdb code 8aoq). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Cereblon Isoform 4 From Magnetospirillum Gryphiswaldense in Complex with Compound 20A, PDB code: 8aoq: Jump to Zinc binding site number: 1; 2; 3; Zinc binding site 1 out of 3 in 8aoqGo back to Zinc Binding Sites List in 8aoq
Zinc binding site 1 out
of 3 in the Cereblon Isoform 4 From Magnetospirillum Gryphiswaldense in Complex with Compound 20A
Mono view Stereo pair view
Zinc binding site 2 out of 3 in 8aoqGo back to Zinc Binding Sites List in 8aoq
Zinc binding site 2 out
of 3 in the Cereblon Isoform 4 From Magnetospirillum Gryphiswaldense in Complex with Compound 20A
Mono view Stereo pair view
Zinc binding site 3 out of 3 in 8aoqGo back to Zinc Binding Sites List in 8aoq
Zinc binding site 3 out
of 3 in the Cereblon Isoform 4 From Magnetospirillum Gryphiswaldense in Complex with Compound 20A
Mono view Stereo pair view
Reference:
M.Krasavin,
M.Adamchik,
A.Bubyrev,
C.Heim,
S.Maiwald,
D.Zhukovsky,
P.Zhmurov,
A.Bunev,
M.D.Hartmann.
Synthesis of Novel Glutarimide Ligands For the E3 Ligase Substrate Receptor Cereblon (Crbn): Investigation of Their Binding Mode and Antiproliferative Effects Against Myeloma Cell Lines. Eur.J.Med.Chem. V. 246 14990 2023.
Page generated: Sat Apr 8 07:44:27 2023
ISSN: ISSN 0223-5234 PubMed: 36476642 DOI: 10.1016/J.EJMECH.2022.114990 |
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