Zinc in PDB 7z8q: Cryo-Em Structure of Mycobacterium Tuberculosis Rna Polymerase Core

Enzymatic activity of Cryo-Em Structure of Mycobacterium Tuberculosis Rna Polymerase Core

All present enzymatic activity of Cryo-Em Structure of Mycobacterium Tuberculosis Rna Polymerase Core:
2.7.7.6;

Other elements in 7z8q:

The structure of Cryo-Em Structure of Mycobacterium Tuberculosis Rna Polymerase Core also contains other interesting chemical elements:

Magnesium (Mg) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Cryo-Em Structure of Mycobacterium Tuberculosis Rna Polymerase Core (pdb code 7z8q). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Cryo-Em Structure of Mycobacterium Tuberculosis Rna Polymerase Core, PDB code: 7z8q:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 7z8q

Go back to Zinc Binding Sites List in 7z8q
Zinc binding site 1 out of 2 in the Cryo-Em Structure of Mycobacterium Tuberculosis Rna Polymerase Core


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of Mycobacterium Tuberculosis Rna Polymerase Core within 5.0Å range:
probe atom residue distance (Å) B Occ
d:Zn1501

b:67.3
occ:1.00
SG d:CYS891 2.3 41.5 1.0
SG d:CYS978 2.3 42.3 1.0
SG d:CYS968 2.3 46.7 1.0
SG d:CYS975 2.3 39.5 1.0
CB d:CYS978 3.1 42.3 1.0
CB d:CYS891 3.2 41.5 1.0
CB d:CYS975 3.2 39.5 1.0
CB d:CYS968 3.3 46.7 1.0
CA d:CYS968 3.5 46.7 1.0
N d:ALA969 3.9 45.1 1.0
NH1 d:ARG963 3.9 45.1 1.0
N d:CYS975 4.0 39.5 1.0
CA d:CYS975 4.1 39.5 1.0
C d:CYS968 4.2 46.7 1.0
OG1 d:THR970 4.3 44.2 1.0
CA d:CYS978 4.3 42.3 1.0
N d:CYS891 4.3 41.5 1.0
CA d:CYS891 4.3 41.5 1.0
N d:CYS978 4.4 42.3 1.0
O d:CYS975 4.5 39.5 1.0
CG2 d:THR893 4.6 46.8 1.0
C d:CYS975 4.6 39.5 1.0
N d:CYS968 4.7 46.7 1.0
N d:THR970 5.0 44.2 1.0

Zinc binding site 2 out of 2 in 7z8q

Go back to Zinc Binding Sites List in 7z8q
Zinc binding site 2 out of 2 in the Cryo-Em Structure of Mycobacterium Tuberculosis Rna Polymerase Core


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryo-Em Structure of Mycobacterium Tuberculosis Rna Polymerase Core within 5.0Å range:
probe atom residue distance (Å) B Occ
d:Zn1502

b:139.8
occ:1.00
SG d:CYS78 2.3 112.8 1.0
SG d:CYS60 2.3 112.4 1.0
SG d:CYS75 2.3 114.7 1.0
SG d:CYS62 2.3 113.6 1.0
CB d:CYS60 3.1 112.4 1.0
CB d:CYS75 3.1 114.7 1.0
CB d:CYS78 3.5 112.8 1.0
N d:CYS62 3.6 113.6 1.0
CB d:CYS62 3.7 113.6 1.0
CB d:LYS64 3.8 115.7 1.0
N d:LYS64 3.9 115.7 1.0
N d:TYR61 4.0 107.6 1.0
N d:CYS78 4.0 112.8 1.0
CA d:CYS62 4.1 113.6 1.0
CA d:CYS60 4.1 112.4 1.0
C d:CYS60 4.2 112.4 1.0
N d:GLY63 4.3 114.8 1.0
CA d:CYS78 4.4 112.8 1.0
CA d:LYS64 4.4 115.7 1.0
C d:CYS62 4.5 113.6 1.0
CB d:ARG77 4.5 113.7 1.0
N d:TYR65 4.6 116.5 1.0
CA d:CYS75 4.6 114.7 1.0
C d:TYR61 4.6 107.6 1.0
CD2 d:TYR65 4.7 116.5 1.0
CA d:TYR61 4.8 107.6 1.0
O d:CYS60 4.9 112.4 1.0
CG2 d:VAL80 4.9 102.7 1.0
C d:ARG77 4.9 113.7 1.0
C d:GLY63 5.0 114.8 1.0
CG d:LYS64 5.0 115.7 1.0

Reference:

Z.Morichaud, S.Trapani, R.K.Vishwakarma, L.Chaloin, C.Lionne, J.Lai-Kee-Him, P.Bron, K.Brodolin. Structural Basis of the Mycobacterial Stress-Response Rna Polymerase Auto-Inhibition Via Oligomerization Nat Commun V. 14 484 2023.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-023-36113-Y
Page generated: Sat Apr 8 06:34:39 2023

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