Zinc in PDB 7z8b: Structure of CRL7FBXW8 Reveals Coupling with CUL1-RBX1/ROC1 For Multi- Cullin-Ring E3-Catalyzed Ubiquitin Ligation

Enzymatic activity of Structure of CRL7FBXW8 Reveals Coupling with CUL1-RBX1/ROC1 For Multi- Cullin-Ring E3-Catalyzed Ubiquitin Ligation

All present enzymatic activity of Structure of CRL7FBXW8 Reveals Coupling with CUL1-RBX1/ROC1 For Multi- Cullin-Ring E3-Catalyzed Ubiquitin Ligation:
2.3.2.27; 2.3.2.32;

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of CRL7FBXW8 Reveals Coupling with CUL1-RBX1/ROC1 For Multi- Cullin-Ring E3-Catalyzed Ubiquitin Ligation (pdb code 7z8b). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Structure of CRL7FBXW8 Reveals Coupling with CUL1-RBX1/ROC1 For Multi- Cullin-Ring E3-Catalyzed Ubiquitin Ligation, PDB code: 7z8b:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in 7z8b

Go back to Zinc Binding Sites List in 7z8b
Zinc binding site 1 out of 3 in the Structure of CRL7FBXW8 Reveals Coupling with CUL1-RBX1/ROC1 For Multi- Cullin-Ring E3-Catalyzed Ubiquitin Ligation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of CRL7FBXW8 Reveals Coupling with CUL1-RBX1/ROC1 For Multi- Cullin-Ring E3-Catalyzed Ubiquitin Ligation within 5.0Å range:
probe atom residue distance (Å) B Occ
R:Zn201

b:146.3
occ:1.00
ND1 R:HIS80 2.0 121.1 1.0
SG R:CYS42 2.3 128.9 1.0
SG R:CYS45 2.3 131.5 1.0
SG R:CYS83 2.3 122.9 1.0
CE1 R:HIS80 2.9 121.1 1.0
CB R:CYS42 3.0 128.9 1.0
CG R:HIS80 3.1 121.1 1.0
CB R:CYS83 3.5 122.9 1.0
CB R:HIS80 3.5 121.1 1.0
CB R:CYS45 3.7 131.5 1.0
N R:CYS45 4.0 131.5 1.0
NE2 R:HIS80 4.0 121.1 1.0
CB R:CYS53 4.0 135.9 1.0
CD2 R:HIS80 4.2 121.1 1.0
N R:HIS80 4.2 121.1 1.0
O R:CYS42 4.3 128.9 1.0
CA R:CYS45 4.4 131.5 1.0
CA R:CYS42 4.4 128.9 1.0
CA R:HIS80 4.5 121.1 1.0
CB R:ILE44 4.5 126.9 1.0
ND2 R:ASN47 4.6 131.4 1.0
CA R:CYS53 4.6 135.9 1.0
C R:CYS42 4.7 128.9 1.0
OD1 R:ASN47 4.7 131.4 1.0
CG2 R:ILE44 4.8 126.9 1.0
CA R:CYS83 4.9 122.9 1.0
C R:ILE44 5.0 126.9 1.0

Zinc binding site 2 out of 3 in 7z8b

Go back to Zinc Binding Sites List in 7z8b
Zinc binding site 2 out of 3 in the Structure of CRL7FBXW8 Reveals Coupling with CUL1-RBX1/ROC1 For Multi- Cullin-Ring E3-Catalyzed Ubiquitin Ligation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of CRL7FBXW8 Reveals Coupling with CUL1-RBX1/ROC1 For Multi- Cullin-Ring E3-Catalyzed Ubiquitin Ligation within 5.0Å range:
probe atom residue distance (Å) B Occ
R:Zn202

b:127.2
occ:1.00
OD2 R:ASP97 2.0 109.5 1.0
ND1 R:HIS77 2.0 100.6 1.0
SG R:CYS94 2.3 112.8 1.0
SG R:CYS75 2.3 99.1 1.0
CE1 R:HIS77 2.7 100.6 1.0
CG R:ASP97 2.7 109.5 1.0
OD1 R:ASP97 3.0 109.5 1.0
CB R:CYS75 3.2 99.1 1.0
CG R:HIS77 3.3 100.6 1.0
CB R:CYS94 3.3 112.8 1.0
CB R:HIS77 3.9 100.6 1.0
NE2 R:HIS77 3.9 100.6 1.0
CB R:ASP97 3.9 109.5 1.0
O R:CYS75 4.2 99.1 1.0
CD2 R:HIS77 4.2 100.6 1.0
N R:ASP97 4.2 109.5 1.0
CA R:CYS75 4.5 99.1 1.0
C R:CYS75 4.5 99.1 1.0
CB R:LEU96 4.7 109.2 1.0
CA R:ASP97 4.7 109.5 1.0
CA R:CYS94 4.8 112.8 1.0
N R:LEU96 4.9 109.2 1.0
N R:HIS77 5.0 100.6 1.0

Zinc binding site 3 out of 3 in 7z8b

Go back to Zinc Binding Sites List in 7z8b
Zinc binding site 3 out of 3 in the Structure of CRL7FBXW8 Reveals Coupling with CUL1-RBX1/ROC1 For Multi- Cullin-Ring E3-Catalyzed Ubiquitin Ligation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of CRL7FBXW8 Reveals Coupling with CUL1-RBX1/ROC1 For Multi- Cullin-Ring E3-Catalyzed Ubiquitin Ligation within 5.0Å range:
probe atom residue distance (Å) B Occ
R:Zn203

b:146.1
occ:1.00
ND1 R:HIS82 2.0 125.5 1.0
SG R:CYS53 2.3 135.9 1.0
SG R:CYS56 2.3 140.8 1.0
SG R:CYS68 2.3 134.8 1.0
CE1 R:HIS82 2.7 125.5 1.0
CG R:HIS82 3.3 125.5 1.0
CB R:CYS56 3.3 140.8 1.0
CB R:CYS68 3.3 134.8 1.0
CB R:CYS53 3.8 135.9 1.0
CB R:HIS82 3.9 125.5 1.0
NE2 R:HIS82 3.9 125.5 1.0
N R:CYS53 4.1 135.9 1.0
N R:CYS56 4.1 140.8 1.0
CA R:CYS68 4.2 134.8 1.0
CD2 R:HIS82 4.2 125.5 1.0
CA R:CYS56 4.4 140.8 1.0
CA R:CYS53 4.5 135.9 1.0
OE1 R:GLU55 4.9 139.7 1.0
CD R:GLU55 4.9 139.7 1.0
O R:CYS53 4.9 135.9 1.0
C R:CYS53 5.0 135.9 1.0

Reference:

L.V.M.Hopf, K.Baek, M.Klugel, S.Von Gronau, Y.Xiong, B.A.Schulman. Structure of CRL7 FBXW8 Reveals Coupling with CUL1-RBX1/ROC1 For Multi-Cullin-Ring E3-Catalyzed Ubiquitin Ligation. Nat.Struct.Mol.Biol. V. 29 854 2022.
ISSN: ESSN 1545-9985
PubMed: 35982156
DOI: 10.1038/S41594-022-00815-6
Page generated: Sat Apr 8 06:34:38 2023

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