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Zinc in PDB 7z78: Crystal Structure of Compound 4 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:ElonginbProtein crystallography data
The structure of Crystal Structure of Compound 4 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb, PDB code: 7z78
was solved by
G.Bader,
J.Boettcher,
B.Wolkerstorfer,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7z78:
The structure of Crystal Structure of Compound 4 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Compound 4 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb
(pdb code 7z78). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of Compound 4 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb, PDB code: 7z78: Jump to Zinc binding site number: 1; 2; 3; 4; Zinc binding site 1 out of 4 in 7z78Go back to Zinc Binding Sites List in 7z78
Zinc binding site 1 out
of 4 in the Crystal Structure of Compound 4 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb
Mono view Stereo pair view
Zinc binding site 2 out of 4 in 7z78Go back to Zinc Binding Sites List in 7z78
Zinc binding site 2 out
of 4 in the Crystal Structure of Compound 4 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb
Mono view Stereo pair view
Zinc binding site 3 out of 4 in 7z78Go back to Zinc Binding Sites List in 7z78
Zinc binding site 3 out
of 4 in the Crystal Structure of Compound 4 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb
Mono view Stereo pair view
Zinc binding site 4 out of 4 in 7z78Go back to Zinc Binding Sites List in 7z78
Zinc binding site 4 out
of 4 in the Crystal Structure of Compound 4 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb
Mono view Stereo pair view
Reference:
C.Kofink,
N.Trainor,
B.Mair,
S.Wohrle,
M.Wurm,
N.Mischerikow,
M.J.Roy,
G.Bader,
P.Greb,
G.Garavel,
E.Diers,
R.Mclennan,
C.Whitworth,
V.Vetma,
K.Rumpel,
M.Scharnweber,
J.E.Fuchs,
T.Gerstberger,
Y.Cui,
G.Gremel,
P.Chetta,
S.Hopf,
N.Budano,
J.Rinnenthal,
G.Gmaschitz,
M.Mayer,
M.Koegl,
A.Ciulli,
H.Weinstabl,
W.Farnaby.
A Selective and Orally Bioavailable Vhl-Recruiting Protac Achieves SMARCA2 Degradation in Vivo. Nat Commun V. 13 5969 2022.
Page generated: Wed Oct 30 16:16:49 2024
ISSN: ESSN 2041-1723 PubMed: 36216795 DOI: 10.1038/S41467-022-33430-6 |
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