Zinc in PDB 8wpm: Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145

The structure of Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145 also contains other interesting chemical elements:

Fluorine	(F)	12 atoms
Chlorine	(Cl)	4 atoms
Calcium	(Ca)	3 atoms

The binding sites of Zinc atom in the Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145 (pdb code 8wpm). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145, PDB code: 8wpm:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn802 b:174.1 occ:1.00 ND1 A:HIS189 2.1 116.0 1.0 SG A:CYS193 2.3 142.9 1.0 SG A:CYS195 2.3 134.5 1.0 SG A:CYS198 2.3 139.8 1.0 CE1 A:HIS189 2.5 114.6 1.0 CG A:HIS189 3.3 112.7 1.0 CB A:CYS198 3.3 133.0 1.0 CB A:CYS193 3.6 137.8 1.0 CB A:CYS195 3.6 136.5 1.0 NE2 A:HIS189 3.7 112.5 1.0 N A:CYS195 4.0 136.0 1.0 CB A:HIS189 4.0 112.2 1.0 N A:CYS198 4.1 132.8 1.0 CD2 A:HIS189 4.1 111.7 1.0 CA A:CYS198 4.3 132.2 1.0 C A:CYS193 4.4 138.3 1.0 CA A:CYS195 4.4 136.7 1.0 O A:CYS193 4.5 137.7 1.0 CA A:CYS193 4.6 138.8 1.0 N A:GLU194 4.7 137.3 1.0

Zinc binding site 2 out of 4 in the Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1002 b:191.7 occ:1.00 ND1 B:HIS172 2.1 115.3 1.0 SG B:CYS178 2.3 126.3 1.0 SG B:CYS176 2.3 131.2 1.0 SG B:CYS181 2.3 125.2 1.0 CE1 B:HIS172 2.8 113.8 1.0 CG B:HIS172 3.0 113.5 1.0 CB B:CYS178 3.0 126.1 1.0 CB B:CYS181 3.2 118.9 1.0 CB B:HIS172 3.5 113.0 1.0 CB B:CYS176 3.5 124.1 1.0 N B:CYS178 3.7 126.1 1.0 NE2 B:HIS172 3.8 112.6 1.0 CD2 B:HIS172 3.9 112.3 1.0 CA B:CYS178 4.0 126.8 1.0 C B:CYS176 4.6 127.2 1.0 N B:ASN177 4.6 138.4 1.0 O B:CYS178 4.6 129.5 1.0 C B:ASN177 4.6 135.5 1.0 CA B:CYS181 4.6 118.3 1.0 CA B:CYS176 4.7 124.3 1.0 C B:CYS178 4.8 128.3 1.0 CA B:HIS172 4.9 111.3 1.0 O B:CYS176 5.0 126.0 1.0

Zinc binding site 3 out of 4 in the Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145 within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn1002 b:181.0 occ:1.00 ND1 C:HIS172 2.1 102.8 1.0 SG C:CYS178 2.3 131.6 1.0 SG C:CYS181 2.3 129.9 1.0 SG C:CYS176 2.3 131.7 1.0 CE1 C:HIS172 2.9 101.6 1.0 CB C:CYS181 3.2 122.8 1.0 CG C:HIS172 3.2 100.4 1.0 CB C:CYS178 3.2 130.4 1.0 CB C:HIS172 3.7 97.6 1.0 CB C:CYS176 3.8 126.9 1.0 N C:CYS178 3.9 131.2 1.0 N C:CYS181 4.0 124.2 1.0 NE2 C:HIS172 4.1 101.8 1.0 CA C:CYS181 4.1 123.0 1.0 CA C:CYS178 4.1 131.4 1.0 CD2 C:HIS172 4.2 100.5 1.0 C C:CYS178 4.7 131.8 1.0 O C:CYS178 4.8 130.6 1.0 C C:CYS176 4.8 130.3 1.0 CA C:CYS176 4.9 128.6 1.0 O C:CYS176 5.0 129.2 1.0

Zinc binding site 4 out of 4 in the Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145 within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn1002 b:169.6 occ:1.00 ND1 D:HIS172 2.1 88.1 1.0 SG D:CYS181 2.3 118.0 1.0 SG D:CYS178 2.3 119.3 1.0 SG D:CYS176 2.3 118.1 1.0 CG D:HIS172 2.8 86.2 1.0 CB D:HIS172 3.0 87.7 1.0 CE1 D:HIS172 3.2 86.8 1.0 CB D:CYS181 3.2 109.9 1.0 CB D:CYS178 3.8 117.6 1.0 CB D:CYS176 3.9 113.5 1.0 CD2 D:HIS172 4.0 83.7 1.0 NE2 D:HIS172 4.2 86.2 1.0 N D:CYS181 4.3 111.6 1.0 CA D:CYS181 4.3 108.9 1.0 CA D:HIS172 4.5 85.1 1.0 N D:CYS178 4.5 119.4 1.0 O D:CYS176 4.7 114.6 1.0 CA D:CYS178 4.7 119.0 1.0 N D:GLU173 4.8 90.5 1.0 C D:CYS176 4.9 114.1 1.0 CA D:CYS176 5.0 114.2 1.0 O D:CYS178 5.0 119.8 1.0

J.Won, H.Jeong, H.H.Lee. Structure of A Trp Channel To Be Published.