Zinc in PDB 7yrg: Histone Methyltransferase

All present enzymatic activity of Histone Methyltransferase:
2.1.1.361; 2.1.1.362;

The binding sites of Zinc atom in the Histone Methyltransferase (pdb code 7yrg). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Histone Methyltransferase, PDB code: 7yrg:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Histone Methyltransferase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Histone Methyltransferase within 5.0Å range: probe atom residue distance (Å) B Occ K:Zn401 b:107.1 occ:1.00 SG K:CYS324 2.3 91.9 1.0 SG K:CYS319 2.3 86.3 1.0 SG K:CYS321 2.3 93.2 1.0 SG K:CYS275 2.3 81.8 1.0 CB K:CYS324 3.3 91.9 1.0 CB K:CYS275 3.3 81.8 1.0 CB K:CYS321 3.5 93.2 1.0 CB K:CYS319 3.6 86.3 1.0 N K:CYS275 3.7 81.8 1.0 N K:CYS324 4.0 91.9 1.0 CA K:CYS275 4.1 81.8 1.0 N K:CYS321 4.2 93.2 1.0 CA K:CYS324 4.2 91.9 1.0 NH2 K:ARG327 4.2 89.8 1.0 CA K:CYS321 4.4 93.2 1.0 NE2 K:HIS273 4.4 85.1 1.0 CD2 K:HIS273 4.5 85.1 1.0 C K:ASP274 4.7 84.0 1.0 C K:CYS319 4.7 86.3 1.0 CA K:CYS319 4.8 86.3 1.0 CA K:ASP274 4.9 84.0 1.0 O K:CYS319 4.9 86.3 1.0 C K:CYS321 5.0 93.2 1.0

Zinc binding site 2 out of 2 in the Histone Methyltransferase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Histone Methyltransferase within 5.0Å range: probe atom residue distance (Å) B Occ L:Zn401 b:107.1 occ:1.00 SG L:CYS324 2.3 91.9 1.0 SG L:CYS319 2.3 86.3 1.0 SG L:CYS321 2.3 93.2 1.0 SG L:CYS275 2.3 81.8 1.0 CB L:CYS324 3.3 91.9 1.0 CB L:CYS275 3.3 81.8 1.0 CB L:CYS321 3.5 93.2 1.0 CB L:CYS319 3.6 86.3 1.0 N L:CYS275 3.7 81.8 1.0 N L:CYS324 4.0 91.9 1.0 CA L:CYS275 4.1 81.8 1.0 N L:CYS321 4.2 93.2 1.0 CA L:CYS324 4.2 91.9 1.0 NH2 L:ARG327 4.2 89.8 1.0 CA L:CYS321 4.4 93.2 1.0 NE2 L:HIS273 4.4 85.1 1.0 CD2 L:HIS273 4.5 85.1 1.0 C L:ASP274 4.7 84.0 1.0 C L:CYS319 4.7 86.3 1.0 CA L:CYS319 4.8 86.3 1.0 CA L:ASP274 4.9 84.0 1.0 O L:CYS319 4.9 86.3 1.0 C L:CYS321 5.0 93.2 1.0

L.Huang, Y.Wang, H.Long, H.Zhu, Z.Wen, L.Zhang, W.Zhang, Z.Guo, L.Wang, F.Tang, J.Hu, K.Bao, P.Zhu, G.Li, Z.Zhou. Structural Insight Into H4K20 Methylation on H2A.Z-Nucleosome By SUV420H1. Mol.Cell V. 83 2884 2023.
ISSN: ISSN 1097-2765
PubMed: 37536340
DOI: 10.1016/J.MOLCEL.2023.07.001