Zinc in PDB 7x1o: Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95

Enzymatic activity of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95

All present enzymatic activity of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95:
6.1.1.15; 6.1.1.17;

Protein crystallography data

The structure of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95, PDB code: 7x1o was solved by Y.Manickam, P.Babbar, A.Sharma, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 33.52 / 2.04
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 72.03, 93.73, 87.09, 90, 109.62, 90
R / Rfree (%) 19.4 / 23.7

Other elements in 7x1o:

The structure of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95 also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms
Bromine (Br) 4 atoms
Calcium (Ca) 4 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95 (pdb code 7x1o). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 5 binding sites of Zinc where determined in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95, PDB code: 7x1o:
Jump to Zinc binding site number: 1; 2; 3; 4; 5;

Zinc binding site 1 out of 5 in 7x1o

Go back to Zinc Binding Sites List in 7x1o
Zinc binding site 1 out of 5 in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1903

b:91.6
occ:0.85
 SG A:CYS1453 2.2 99.0 1.0
SG A:CYS1495 2.3 87.7 1.0
SG A:CYS1497 2.4 95.9 1.0
SG A:CYS1448 2.4 91.7 1.0
CB A:CYS1453 3.0 101.4 1.0
CB A:CYS1497 3.1 97.7 1.0
CB A:CYS1495 3.1 96.2 1.0
CB A:CYS1448 3.5 92.2 1.0
N A:CYS1497 3.9 101.2 1.0
CA A:CYS1497 4.1 105.6 1.0
N A:CYS1448 4.1 87.7 1.0
CE1 A:PHE1447 4.3 74.6 1.0
CD1 A:PHE1447 4.4 81.7 1.0
CA A:CYS1453 4.4 96.9 1.0
CA A:CYS1448 4.4 89.0 1.0
CA A:CYS1495 4.5 102.5 1.0
N A:VAL1496 4.8 100.9 1.0
C A:CYS1495 4.8 100.7 1.0
N A:GLY1449 5.0 89.4 1.0

Zinc binding site 2 out of 5 in 7x1o

Go back to Zinc Binding Sites List in 7x1o
Zinc binding site 2 out of 5 in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1905

b:112.7
occ:0.84
 SG A:CYS1301 2.4 75.5 1.0
OE2 B:GLU1074 3.6 85.4 1.0
CB A:CYS1301 3.7 52.9 1.0
CB A:ALA1055 4.0 43.1 1.0
O A:PRO1051 4.2 40.6 1.0
CE3 A:TRP1052 4.3 47.9 1.0
O B:HOH2098 4.5 79.1 1.0
CZ3 A:TRP1052 4.6 46.1 1.0
O B:HOH2012 4.6 41.4 1.0
C A:PRO1051 4.6 43.1 1.0
CD B:GLU1074 4.8 74.3 1.0
CB A:PRO1051 4.8 42.6 1.0
CA A:TRP1052 5.0 42.9 1.0
CA A:CYS1301 5.0 60.5 1.0

Zinc binding site 3 out of 5 in 7x1o

Go back to Zinc Binding Sites List in 7x1o
Zinc binding site 3 out of 5 in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1908

b:129.5
occ:0.85
 SG B:CYS1301 2.4 65.1 1.0
OE2 A:GLU1074 3.4 75.0 1.0
CB B:CYS1301 3.7 43.1 1.0
O B:PRO1051 3.8 39.3 1.0
CB B:PRO1051 4.1 39.5 1.0
CB B:ALA1055 4.1 38.5 1.0
C B:PRO1051 4.1 43.8 1.0
CD A:GLU1074 4.4 64.8 1.0
CE3 B:TRP1052 4.5 44.2 1.0
N B:TRP1052 4.6 40.0 1.0
CA B:TRP1052 4.6 43.7 1.0
CA B:PRO1051 4.7 42.6 1.0
O A:HOH2057 4.8 56.3 1.0
CZ3 B:TRP1052 4.9 50.5 1.0

Zinc binding site 4 out of 5 in 7x1o

Go back to Zinc Binding Sites List in 7x1o
Zinc binding site 4 out of 5 in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn1903

b:94.7
occ:0.98
 SG B:CYS1495 2.2 87.8 1.0
SG B:CYS1448 2.3 92.6 1.0
SG B:CYS1453 2.3 85.7 1.0
SG B:CYS1497 2.3 96.7 1.0
CB B:CYS1497 3.2 93.0 1.0
CB B:CYS1453 3.2 83.7 1.0
CB B:CYS1448 3.2 92.5 1.0
CB B:CYS1495 3.3 86.5 1.0
N B:CYS1448 3.9 83.6 1.0
N B:CYS1497 4.0 95.3 1.0
CA B:CYS1448 4.2 88.0 1.0
CA B:CYS1497 4.2 95.2 1.0
CE1 B:PHE1447 4.2 72.0 1.0
CD1 B:PHE1447 4.2 76.4 1.0
OD1 B:ASN1500 4.3 110.2 1.0
CA B:CYS1495 4.5 94.5 1.0
C B:CYS1495 4.6 99.9 1.0
CA B:CYS1453 4.7 83.8 1.0
N B:VAL1496 4.9 98.1 1.0
O B:CYS1495 4.9 100.3 1.0
C B:CYS1448 5.0 87.2 1.0

Zinc binding site 5 out of 5 in 7x1o

Go back to Zinc Binding Sites List in 7x1o
Zinc binding site 5 out of 5 in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn1908

b:136.0
occ:0.70
 SG B:CYS1377 2.5 87.1 1.0
CB B:CYS1377 3.7 70.9 1.0
N B:CYS1377 4.1 65.6 1.0
C B:SER1376 4.3 67.9 1.0
O B:LYS1375 4.5 76.1 1.0
CA B:CYS1377 4.5 68.7 1.0
CA B:SER1376 4.6 75.5 1.0
O B:SER1376 4.8 71.0 1.0
C B:LYS1375 4.8 76.3 1.0
N B:SER1376 5.0 73.8 1.0

Reference:

Y.Manickam, P.Babbar, A.Sharma. Crystal Structure of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) with Double Inhibitors (Hf and L95) To Be Published.
Page generated: Wed Oct 30 14:40:30 2024

Last articles

Zn in 9MJ5
Zn in 9HNW
Zn in 9G0L
Zn in 9FNE
Zn in 9DZN
Zn in 9E0I
Zn in 9D32
Zn in 9DAK
Zn in 8ZXC
Zn in 8ZUF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy