Zinc in PDB 7v61: ACE2 -Targeting Monoclonal Antibody As Potent and Broad-Spectrum Coronavirus Blocker

Enzymatic activity of ACE2 -Targeting Monoclonal Antibody As Potent and Broad-Spectrum Coronavirus Blocker

All present enzymatic activity of ACE2 -Targeting Monoclonal Antibody As Potent and Broad-Spectrum Coronavirus Blocker:
3.4.17.23;

Zinc Binding Sites:

The binding sites of Zinc atom in the ACE2 -Targeting Monoclonal Antibody As Potent and Broad-Spectrum Coronavirus Blocker (pdb code 7v61). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the ACE2 -Targeting Monoclonal Antibody As Potent and Broad-Spectrum Coronavirus Blocker, PDB code: 7v61:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 7v61

Go back to Zinc Binding Sites List in 7v61
Zinc binding site 1 out of 2 in the ACE2 -Targeting Monoclonal Antibody As Potent and Broad-Spectrum Coronavirus Blocker


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of ACE2 -Targeting Monoclonal Antibody As Potent and Broad-Spectrum Coronavirus Blocker within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn902

b:75.6
occ:1.00
OE2 B:GLU402 2.7 42.8 1.0
CD B:GLU402 3.6 42.8 1.0
NE2 B:HIS374 3.8 52.8 1.0
OE2 B:GLU375 4.0 58.5 1.0
OE1 B:GLU402 4.0 42.8 1.0
NE2 B:HIS378 4.2 50.2 1.0
CD2 B:HIS374 4.5 52.8 1.0
O B:PRO346 4.5 75.1 1.0
CG B:GLU402 4.7 42.8 1.0
CD2 B:HIS378 4.9 50.2 1.0
CE1 B:HIS374 4.9 52.8 1.0
CD B:GLU375 4.9 58.5 1.0

Zinc binding site 2 out of 2 in 7v61

Go back to Zinc Binding Sites List in 7v61
Zinc binding site 2 out of 2 in the ACE2 -Targeting Monoclonal Antibody As Potent and Broad-Spectrum Coronavirus Blocker


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of ACE2 -Targeting Monoclonal Antibody As Potent and Broad-Spectrum Coronavirus Blocker within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn902

b:75.6
occ:1.00
OE2 D:GLU402 2.7 42.8 1.0
CD D:GLU402 3.6 42.8 1.0
NE2 D:HIS374 3.8 52.8 1.0
OE2 D:GLU375 4.0 58.5 1.0
OE1 D:GLU402 4.0 42.8 1.0
NE2 D:HIS378 4.2 50.2 1.0
CD2 D:HIS374 4.5 52.8 1.0
O D:PRO346 4.5 75.1 1.0
CG D:GLU402 4.7 42.8 1.0
CD2 D:HIS378 4.9 50.2 1.0
CE1 D:HIS374 4.9 52.8 1.0
CD D:GLU375 4.9 58.5 1.0

Reference:

Y.Chen, Y.N.Zhang, R.Yan, G.Wang, Y.Zhang, Z.R.Zhang, Y.Li, J.Ou, W.Chu, Z.Liang, Y.Wang, Y.L.Chen, G.Chen, Q.Wang, Q.Zhou, B.Zhang, C.Wang. ACE2-Targeting Monoclonal Antibody As Potent and Broad-Spectrum Coronavirus Blocker. Signal Transduct Target Ther V. 6 315 2021.
ISSN: ESSN 2059-3635
PubMed: 34433803
DOI: 10.1038/S41392-021-00740-Y
Page generated: Sat Apr 8 04:40:30 2023

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