Zinc in PDB 7uyz: Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2 ,5 )Pg

All present enzymatic activity of Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2 ,5 )Pg:
2.7.7.86;

The structure of Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2 ,5 )Pg, PDB code: 7uyz was solved by S.Wu, S.B.Gabelli, J.Sohn, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.85 / 2.49
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	78.341, 98.515, 142.695, 90, 90, 90
R / Rfree (%)	21.4 / 25.1

The structure of Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2 ,5 )Pg also contains other interesting chemical elements:

Magnesium

(Mg)

4 atoms

The binding sites of Zinc atom in the Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2 ,5 )Pg (pdb code 7uyz). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2 ,5 )Pg, PDB code: 7uyz:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2 ,5 )Pg


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2 ,5 )Pg within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn603 b:31.8 occ:1.00 NE2 A:HIS378 2.0 33.4 1.0 SG A:CYS385 2.3 35.1 1.0 SG A:CYS384 2.3 31.7 1.0 SG A:CYS392 2.3 33.9 1.0 CD2 A:HIS378 2.9 33.3 1.0 CE1 A:HIS378 3.0 33.1 1.0 CB A:CYS392 3.3 33.5 1.0 CB A:CYS385 3.3 33.2 1.0 CB A:CYS384 3.6 31.0 1.0 N A:CYS392 3.7 34.7 1.0 C A:CYS384 3.8 31.6 1.0 N A:CYS385 3.9 32.8 1.0 CA A:CYS392 4.0 34.2 1.0 O A:HOH726 4.0 40.8 1.0 CG A:HIS378 4.1 33.4 1.0 ND1 A:HIS378 4.1 32.4 1.0 CA A:CYS385 4.1 32.8 1.0 O A:CYS384 4.2 30.2 1.0 CA A:CYS384 4.2 30.7 1.0 NH1 A:ARG394 4.4 33.7 1.0 C A:CYS392 4.6 34.5 1.0 O A:CYS392 4.6 35.5 1.0 C A:LYS391 4.8 37.2 1.0 O A:ALA390 4.9 35.2 1.0

Zinc binding site 2 out of 2 in the Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2 ,5 )Pg


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2 ,5 )Pg within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn603 b:31.9 occ:1.00 NE2 C:HIS378 2.0 32.3 1.0 SG C:CYS385 2.3 35.7 1.0 SG C:CYS384 2.3 33.0 1.0 SG C:CYS392 2.4 34.2 1.0 CD2 C:HIS378 2.9 30.9 1.0 CE1 C:HIS378 3.0 31.6 1.0 CB C:CYS385 3.3 34.9 1.0 CB C:CYS392 3.3 35.4 1.0 CB C:CYS384 3.6 33.4 1.0 N C:CYS392 3.8 37.2 1.0 C C:CYS384 3.8 33.4 1.0 N C:CYS385 3.8 33.8 1.0 O C:HOH723 3.9 31.0 1.0 CA C:CYS392 4.0 36.3 1.0 ND1 C:HIS378 4.1 30.9 1.0 CG C:HIS378 4.1 30.6 1.0 CA C:CYS385 4.1 34.9 1.0 O C:CYS384 4.1 31.7 1.0 CA C:CYS384 4.2 33.1 1.0 NH1 C:ARG394 4.3 31.4 1.0 O C:HOH709 4.4 34.6 1.0 C C:CYS392 4.6 35.3 1.0 O C:CYS392 4.6 36.0 1.0 O C:ALA390 4.8 38.1 1.0 C C:LYS391 4.8 40.3 1.0

S.Wu, S.B.Gabelli, J.S.Sohn. Structure of Ternary Complex of Cgas with Dsdna and Bound 5 -Pppg(2 ,5 )Pg To Be Published.