Zinc in PDB 7tnz: Cryo-Em Structure of Rig-I in Complex with P1DSRNA

All present enzymatic activity of Cryo-Em Structure of Rig-I in Complex with P1DSRNA:
3.6.4.13;

The binding sites of Zinc atom in the Cryo-Em Structure of Rig-I in Complex with P1DSRNA (pdb code 7tnz). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Cryo-Em Structure of Rig-I in Complex with P1DSRNA, PDB code: 7tnz:

Zinc binding site 1 out of 1 in the Cryo-Em Structure of Rig-I in Complex with P1DSRNA


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of Rig-I in Complex with P1DSRNA within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:69.4 occ:1.00 SG A:CYS869 2.5 96.4 1.0 SG A:CYS864 2.5 94.7 1.0 SG A:CYS810 2.6 89.3 1.0 CB A:CYS813 2.6 93.9 1.0 CB A:CYS810 3.1 84.5 1.0 SG A:CYS813 3.3 105.7 1.0 CB A:CYS869 3.5 103.3 1.0 CB A:CYS864 3.7 96.9 1.0 CA A:CYS813 3.9 89.9 1.0 N A:CYS813 4.1 89.6 1.0 CZ2 A:TRP873 4.4 70.5 1.0 CG A:ARG866 4.4 145.1 1.0 C A:CYS813 4.6 85.5 1.0 CA A:CYS810 4.6 83.5 1.0 CB A:ARG866 4.7 140.8 1.0 CB A:ALA815 4.7 98.7 1.0 N A:LYS814 4.8 85.0 1.0 NE1 A:TRP873 4.9 68.3 1.0 CA A:CYS869 4.9 106.1 1.0 CE2 A:TRP873 4.9 67.6 1.0 CG A:LYS812 4.9 86.7 1.0 N A:ALA815 5.0 95.2 1.0

W.Wang, A.M.Pyle. The Rig-I Receptor Adopts Two Different Conformations For Distinguishing Host From Viral Rna Ligands. Mol.Cell V. 82 4131 2022.
ISSN: ISSN 1097-2765
PubMed: 36272408
DOI: 10.1016/J.MOLCEL.2022.09.029