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Zinc in PDB 7t0a: Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2FEnzymatic activity of Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F
All present enzymatic activity of Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F:
2.5.1.58; Protein crystallography data
The structure of Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F, PDB code: 7t0a
was solved by
Y.Wang,
Y.Shi,
L.S.Beese,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7t0a:
The structure of Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F
(pdb code 7t0a). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F, PDB code: 7t0a: Zinc binding site 1 out of 1 in 7t0aGo back to Zinc Binding Sites List in 7t0a
Zinc binding site 1 out
of 1 in the Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F
Mono view Stereo pair view
Reference:
Y.Wang,
F.Xu,
C.B.Nichols,
Y.Shi,
H.W.Hellinga,
J.A.Alspaugh,
M.D.Distefano,
L.S.Beese.
Structure-Guided Discovery of Potent Antifungals That Prevent Ras Signaling By Inhibiting Protein Farnesyltransferase. J.Med.Chem. V. 65 13753 2022.
Page generated: Wed Oct 30 11:23:57 2024
ISSN: ISSN 0022-2623 PubMed: 36218371 DOI: 10.1021/ACS.JMEDCHEM.2C00902 |
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