Zinc in PDB 7s1u: Structure of Human POT1C

The structure of Structure of Human POT1C, PDB code: 7s1u was solved by T.Aramburu, E.Skordalakes, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.00 / 2.55
Space group	P 32 2 1
Cell size a, b, c (Å), α, β, γ (°)	162.88, 162.88, 63.62, 90, 90, 120
R / Rfree (%)	18.5 / 21.3

The binding sites of Zinc atom in the Structure of Human POT1C (pdb code 7s1u). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of Human POT1C, PDB code: 7s1u:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of Human POT1C


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Human POT1C within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn700 b:61.5 occ:1.00 SG A:CYS382 2.3 48.1 1.0 SG A:CYS503 2.3 55.0 1.0 SG A:CYS385 2.3 72.6 1.0 SG A:CYS506 2.3 59.7 1.0 CB A:CYS385 2.7 46.9 1.0 CB A:CYS382 2.9 34.9 1.0 CB A:CYS506 3.2 37.1 1.0 CB A:CYS503 3.4 43.4 1.0 N A:CYS385 3.6 49.6 1.0 CA A:CYS385 3.7 35.8 1.0 CA A:CYS382 4.4 43.8 1.0 CA A:CYS506 4.4 34.8 1.0 C A:CYS385 4.5 33.2 1.0 N A:CYS506 4.5 48.9 1.0 CD2 A:LEU387 4.5 87.9 1.0 N A:HIS386 4.7 41.7 1.0 C A:LYS384 4.8 46.1 1.0 CA A:CYS503 4.8 43.5 1.0 CG A:LEU387 4.8 64.7 1.0 C A:CYS382 5.0 46.5 1.0

Zinc binding site 2 out of 2 in the Structure of Human POT1C


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Human POT1C within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn700 b:73.8 occ:1.00 SG B:CYS506 2.3 69.6 1.0 SG B:CYS382 2.3 60.0 1.0 SG B:CYS503 2.3 69.8 1.0 SG B:CYS385 2.4 59.6 1.0 CB B:CYS382 3.5 40.8 1.0 CB B:CYS503 3.6 71.9 1.0 CB B:CYS506 3.6 53.7 1.0 CB B:CYS385 3.9 45.4 1.0 N B:CYS506 4.0 63.7 1.0 N B:CYS385 4.1 55.7 1.0 CA B:CYS506 4.4 65.1 1.0 CA B:CYS385 4.6 43.5 1.0 OE1 B:GLN505 4.6 76.5 1.0 CG1 B:VAL536 4.6 43.6 1.0 CB B:LYS384 4.7 31.1 1.0 CB B:VAL536 4.7 43.9 1.0 CA B:CYS503 4.8 76.8 1.0 O B:CYS503 4.8 52.3 1.0 CB B:GLN505 4.8 42.8 1.0 CA B:CYS382 4.9 40.9 1.0 C B:CYS506 4.9 54.0 1.0 C B:CYS503 5.0 54.2 1.0

T.Aramburu, J.Kelich, C.Rice, E.Skordalakes. POT1-TPP1 Binding Stabilizes POT1, Promoting Efficient Telomere Maintenance. Comput Struct Biotechnol J V. 20 675 2022.
ISSN: ESSN 2001-0370
PubMed: 35140887
DOI: 10.1016/J.CSBJ.2022.01.005