Zinc in PDB 8hir: Potassium Channels

The structure of Potassium Channels also contains other interesting chemical elements:

Potassium	(K)	4 atoms
Sodium	(Na)	4 atoms

The binding sites of Zinc atom in the Potassium Channels (pdb code 8hir). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Potassium Channels, PDB code: 8hir:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Potassium Channels


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Potassium Channels within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1307 b:30.0 occ:1.00 ND1 A:HIS787 1.9 133.1 1.0 SG A:CYS777 2.3 113.9 1.0 SG A:CYS785 2.3 138.4 1.0 CE1 A:HIS787 2.4 131.7 1.0 SG A:CYS778 2.5 115.7 1.0 CG A:HIS787 3.1 135.3 1.0 CB A:CYS785 3.3 135.9 1.0 N A:CYS778 3.3 103.0 1.0 CB A:CYS778 3.5 106.0 1.0 CG A:PRO775 3.6 110.8 1.0 NE2 A:HIS787 3.6 131.8 1.0 CA A:CYS778 3.7 105.5 1.0 CB A:CYS777 3.7 108.2 1.0 C A:CYS777 3.8 106.8 1.0 CB A:HIS787 3.9 133.7 1.0 CD2 A:HIS787 4.0 134.6 1.0 CA A:CYS777 4.2 106.5 1.0 CB A:PRO775 4.3 109.9 1.0 N A:HIS787 4.3 134.4 1.0 O A:CYS777 4.3 104.8 1.0 CA A:CYS785 4.7 133.8 1.0 N A:CYS777 4.7 106.2 1.0 N A:LYS786 4.7 137.5 1.0 CA A:HIS787 4.8 134.5 1.0 CD A:PRO775 4.8 105.8 1.0 O A:PRO775 5.0 106.9 1.0

Zinc binding site 2 out of 4 in the Potassium Channels


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Potassium Channels within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1303 b:30.0 occ:1.00 ND1 B:HIS787 1.8 133.2 1.0 SG B:CYS785 2.3 136.8 1.0 SG B:CYS778 2.3 117.0 1.0 CE1 B:HIS787 2.4 132.0 1.0 SG B:CYS777 2.5 113.5 1.0 CG B:HIS787 3.0 135.4 1.0 N B:CYS778 3.4 103.7 1.0 CB B:CYS785 3.4 134.9 1.0 CB B:CYS778 3.4 106.6 1.0 CG B:PRO775 3.6 110.0 1.0 CA B:CYS778 3.6 105.7 1.0 NE2 B:HIS787 3.6 132.1 1.0 CB B:HIS787 3.7 133.7 1.0 C B:CYS777 3.8 107.4 1.0 CB B:CYS777 3.9 108.4 1.0 CD2 B:HIS787 3.9 134.8 1.0 N B:HIS787 4.2 134.5 1.0 CB B:PRO775 4.4 108.9 1.0 O B:CYS777 4.4 105.2 1.0 CA B:CYS777 4.4 106.8 1.0 CA B:HIS787 4.6 134.5 1.0 CD B:PRO775 4.7 105.4 1.0 CA B:CYS785 4.8 132.6 1.0 N B:LYS786 4.8 137.4 1.0 N B:CYS777 4.9 106.3 1.0 O B:PRO775 5.0 106.6 1.0

Zinc binding site 3 out of 4 in the Potassium Channels


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Potassium Channels within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn1303 b:30.0 occ:1.00 ND1 C:HIS787 1.5 133.6 1.0 CE1 C:HIS787 2.2 132.1 1.0 SG C:CYS785 2.2 137.3 1.0 SG C:CYS778 2.5 115.8 1.0 SG C:CYS777 2.5 112.9 1.0 CG C:HIS787 2.8 135.8 1.0 CB C:CYS785 3.3 134.9 1.0 NE2 C:HIS787 3.4 132.1 1.0 CB C:HIS787 3.6 134.1 1.0 N C:CYS778 3.7 103.6 1.0 CD2 C:HIS787 3.7 134.9 1.0 CB C:CYS778 3.7 106.6 1.0 CG C:PRO775 3.7 110.9 1.0 CA C:CYS778 3.9 105.7 1.0 N C:HIS787 4.0 134.8 1.0 CB C:CYS777 4.0 107.6 1.0 C C:CYS777 4.1 107.2 1.0 CA C:HIS787 4.4 134.9 1.0 CB C:PRO775 4.5 109.5 1.0 N C:LYS786 4.5 137.5 1.0 CA C:CYS777 4.6 106.4 1.0 O C:CYS777 4.6 105.1 1.0 CA C:CYS785 4.7 132.6 1.0 C C:CYS785 4.9 134.4 1.0 CD C:PRO775 4.9 106.4 1.0

Zinc binding site 4 out of 4 in the Potassium Channels


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Potassium Channels within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn1303 b:30.0 occ:1.00 ND1 D:HIS787 1.8 133.5 1.0 SG D:CYS785 2.0 137.1 1.0 SG D:CYS778 2.4 118.4 1.0 CE1 D:HIS787 2.5 132.1 1.0 SG D:CYS777 2.6 116.5 1.0 CG D:HIS787 3.0 135.7 1.0 CB D:CYS785 3.1 135.4 1.0 N D:CYS778 3.4 105.0 1.0 CB D:CYS778 3.5 108.5 1.0 CA D:CYS778 3.6 107.7 1.0 CB D:HIS787 3.6 134.1 1.0 NE2 D:HIS787 3.7 132.2 1.0 C D:CYS777 3.8 109.1 1.0 CG D:PRO775 3.9 112.1 1.0 CB D:CYS777 3.9 110.2 1.0 CD2 D:HIS787 4.0 134.8 1.0 N D:HIS787 4.0 134.7 1.0 O D:CYS777 4.3 107.3 1.0 CA D:CYS777 4.4 108.9 1.0 CA D:HIS787 4.5 134.9 1.0 CA D:CYS785 4.5 133.4 1.0 N D:LYS786 4.6 137.2 1.0 CB D:PRO775 4.7 111.0 1.0 C D:CYS785 4.8 134.7 1.0 N D:ASN788 4.9 140.8 1.0 N D:CYS777 5.0 108.3 1.0

J.Zhang, S.Liu, J.Fan, R.Yan, B.Huang, F.Zhou, T.Yuan, J.Gong, Z.Huang, D.Jiang. Structural Basis of Human SLO2.2 Channel Gating and Modulation. Cell Rep V. 42 12858 2023.
ISSN: ESSN 2211-1247
PubMed: 37494189
DOI: 10.1016/J.CELREP.2023.112858