Zinc in PDB 7dxb: Structure of TRPC3 at 2.7 Angstrom in High Calcium State

The structure of Structure of TRPC3 at 2.7 Angstrom in High Calcium State also contains other interesting chemical elements:

Calcium

(Ca)

12 atoms

The binding sites of Zinc atom in the Structure of TRPC3 at 2.7 Angstrom in High Calcium State (pdb code 7dxb). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Structure of TRPC3 at 2.7 Angstrom in High Calcium State, PDB code: 7dxb:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Structure of TRPC3 at 2.7 Angstrom in High Calcium State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of TRPC3 at 2.7 Angstrom in High Calcium State within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn904 b:67.7 occ:1.00 ND1 A:HIS178 2.1 35.6 1.0 SG A:CYS182 2.3 37.0 1.0 SG A:CYS187 2.3 57.8 1.0 SG A:CYS184 2.4 46.9 1.0 CG A:HIS178 3.0 26.0 1.0 CE1 A:HIS178 3.1 33.1 1.0 CB A:CYS187 3.2 30.0 1.0 CB A:HIS178 3.3 21.4 1.0 CB A:CYS182 3.4 27.3 1.0 CB A:CYS184 3.5 33.6 1.0 N A:CYS187 4.1 30.3 1.0 CD2 A:HIS178 4.2 23.3 1.0 NE2 A:HIS178 4.2 26.2 1.0 N A:CYS184 4.2 31.3 1.0 CA A:CYS187 4.2 26.5 1.0 CA A:CYS184 4.4 32.8 1.0 CA A:CYS182 4.7 23.6 1.0 CA A:HIS178 4.8 19.8 1.0 C A:CYS184 4.8 33.6 1.0 O A:CYS184 4.9 36.5 1.0 C A:CYS182 4.9 30.8 1.0

Zinc binding site 2 out of 4 in the Structure of TRPC3 at 2.7 Angstrom in High Calcium State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of TRPC3 at 2.7 Angstrom in High Calcium State within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1105 b:67.7 occ:1.00 ND1 B:HIS178 2.1 35.6 1.0 SG B:CYS182 2.3 37.0 1.0 SG B:CYS187 2.3 57.8 1.0 SG B:CYS184 2.4 46.9 1.0 CG B:HIS178 3.0 26.0 1.0 CE1 B:HIS178 3.1 33.1 1.0 CB B:CYS187 3.2 30.0 1.0 CB B:HIS178 3.3 21.4 1.0 CB B:CYS182 3.4 27.3 1.0 CB B:CYS184 3.5 33.6 1.0 N B:CYS187 4.1 30.3 1.0 CD2 B:HIS178 4.2 23.3 1.0 NE2 B:HIS178 4.2 26.2 1.0 N B:CYS184 4.2 31.3 1.0 CA B:CYS187 4.2 26.5 1.0 CA B:CYS184 4.4 32.8 1.0 CA B:CYS182 4.7 23.6 1.0 CA B:HIS178 4.8 19.8 1.0 C B:CYS184 4.8 33.6 1.0 O B:CYS184 4.9 36.5 1.0 C B:CYS182 4.9 30.8 1.0

Zinc binding site 3 out of 4 in the Structure of TRPC3 at 2.7 Angstrom in High Calcium State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of TRPC3 at 2.7 Angstrom in High Calcium State within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn1105 b:67.7 occ:1.00 ND1 C:HIS178 2.1 35.6 1.0 SG C:CYS182 2.3 37.0 1.0 SG C:CYS187 2.3 57.8 1.0 SG C:CYS184 2.4 46.9 1.0 CG C:HIS178 3.0 26.0 1.0 CE1 C:HIS178 3.1 33.1 1.0 CB C:CYS187 3.2 30.0 1.0 CB C:HIS178 3.3 21.4 1.0 CB C:CYS182 3.4 27.3 1.0 CB C:CYS184 3.5 33.6 1.0 N C:CYS187 4.1 30.3 1.0 CD2 C:HIS178 4.2 23.3 1.0 NE2 C:HIS178 4.2 26.2 1.0 N C:CYS184 4.2 31.3 1.0 CA C:CYS187 4.2 26.5 1.0 CA C:CYS184 4.4 32.8 1.0 CA C:CYS182 4.7 23.6 1.0 CA C:HIS178 4.8 19.8 1.0 C C:CYS184 4.8 33.6 1.0 O C:CYS184 4.9 36.5 1.0 C C:CYS182 4.9 30.8 1.0

Zinc binding site 4 out of 4 in the Structure of TRPC3 at 2.7 Angstrom in High Calcium State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of TRPC3 at 2.7 Angstrom in High Calcium State within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn1104 b:67.7 occ:1.00 ND1 D:HIS178 2.1 35.6 1.0 SG D:CYS182 2.3 37.0 1.0 SG D:CYS187 2.3 57.8 1.0 SG D:CYS184 2.4 46.9 1.0 CG D:HIS178 3.0 26.0 1.0 CE1 D:HIS178 3.1 33.1 1.0 CB D:CYS187 3.2 30.0 1.0 CB D:HIS178 3.3 21.4 1.0 CB D:CYS182 3.4 27.3 1.0 CB D:CYS184 3.5 33.6 1.0 N D:CYS187 4.1 30.3 1.0 CD2 D:HIS178 4.2 23.3 1.0 NE2 D:HIS178 4.2 26.2 1.0 N D:CYS184 4.2 31.3 1.0 CA D:CYS187 4.2 26.5 1.0 CA D:CYS184 4.4 32.8 1.0 CA D:CYS182 4.7 23.6 1.0 CA D:HIS178 4.8 19.8 1.0 C D:CYS184 4.8 33.6 1.0 O D:CYS184 4.9 36.5 1.0 C D:CYS182 4.9 30.8 1.0

W.Guo, Q.Tang, M.Wei, Y.Kang, J.X.Wu, L.Chen. Structural Mechanism of Human TRPC3 and TRPC6 Channel Regulation By Their Intracellular Calcium-Binding Sites. Neuron V. 110 1023 2022.
ISSN: ISSN 0896-6273
PubMed: 35051376
DOI: 10.1016/J.NEURON.2021.12.023